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| 1 | Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis显示文摘BACKGROUND Liver cirrhosis is a significant source of morbidity and mortality worldwide.The disease is usually indolent and asymptomatic early in its course while many cirrhotic patients are diagnosed late when severe complications occur.A major challenge is to diagnose advanced fibrosis as early as possible,using simple and non-invasive diagnostics tools.Thrombocytopenia represents advanced fibrosis and portal hypertension(HTN)and most non-invasive scores that predict liver fibrosis incorporate platelets as a strong risk factor.However,little is known about the association between longitudinal changes in platelet counts(PTC),when still within the normal range,and the risk of cirrhosis.AIM To explore whether platelet counts trajectories over time,can predict advanced liver fibrosis across the different etiologies of liver diseases.METHODS A nested case-control study utilizing a large computerized database.Cirrhosis cases(n=5258)were compared to controls(n=15744)matched for age and sex at a ratio of 1:3.All participants had multiple laboratory measurements prior to enrollment.We calculated the trends of PTC,liver enzymes,bilirubin,international normalized ratio,albumin and fibrosis scores(fibrosis-4 and aspartate transaminase-to-platelet ratio index)throughout the preceding 20 years prior to cirrhosis diagnosis compared to healthy controls.The association between PTC,cirrhosis complications and fibrosis scores prior to cirrhosis diagnosis was investigated.RESULTS The mean age in both groups was 56(SD 15.8).Cirrhotic patients were more likely to be smokers,diabetic with chronic kidney disease and had a higher prevalence of HTN.The leading cirrhosis etiologies were viral,alcoholic and fatty liver disease.The mean PTC decreased from 240000/μL to 190000/μL up to 15 years prior to cirrhosis diagnosis compared to controls who’s PTC remained stable around the values of 240000/μL.This trend was consistent regardless of sex,cirrhosis etiology and was more pronounced in patients who developed varices and ascites.Compared to controls whose values remained in the normal range,in the cirrhosis group aspartate aminotransferase and alanine aminotransferase,increased from 40 U/L to 75 U/L and FIB-4 increased gradually from 1.3 to 3 prior to cirrhosis diagnosis.In multivariable regression analysis,a decrease of 50 units in PTC was associated with 1.3 times odds of cirrhosis(95%CI 1.25-1.35).CONCLUSION In the preceding years before the diagnosis of cirrhosis,there is a progressive decline in PTC,within the normal range,matched to a gradual increase in fibrosis scores. | Neta Gotlieb Naama Schwartz Shira Zelber-Sagi Gabriel Chodick Varda Shalev Oren Shibolet | 2020 | World Journal of Gastroenterology2020，26，38： | 3 |
| 2 | 宫颈粒细胞肉瘤显示文摘Background. Granulocytic sarcoma of the cervix, leading to the diagnosis of acute myelogenous leukemia (AML), is a rare event. Case. A 33- year- old woman presented with vaginal bleeding, pain, and a large pelvic mass involving the cervix, extending bilaterally to the pelvic side walls. A biopsy of the cervix revealed granulocytic sarcoma, and a subsequent bone marrow biopsy confirmed the diagnosis of AML. Results. The majority of patients with cervical granulocytic sarcoma present with vaginal bleeding, sometimes with abdominal pain and other systemic symptoms. The overall 2- year survival rates for all patients with granulocytic sarcoma in the literature is 6% , and none of the patients lived 5 years. Conclusion. Granulocytic sarcoma of the cervix is rare. Awareness of this entity will allow earlier diagnosis and appropriate treatment. | Pathak B. Bruchim I. Brisson M.- L. W.H. Gotlieb 杨晓梅 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，1： | 3 |
| 3 | Atherosclerosis and acute coronary syndromes显示文摘 | Gotlieb AI | 2005 | Cardiovasc Pathol2005，14，4： | 1 |
| 4 | Wall tissue remodeling regulates longitudenal tension in arteries显示文摘 | Jackson ZS Gotlieb AI Langille BL | 2002 | Circ Res2002，90，8： | 1 |
| 5 | Insulin-like growth factor receptor I targeting in epithelial ovarian cancer显示文摘 | Gotlieb WH Bruchim I Gu J | 2006 | Gynecol Oncol2006，100，2： | 1 |
| 6 | Chemical and physical transitions of periodate oxidized potato starch in water显示文摘 | V eelaert S Wit D Gotlieb K | 1994 | Carbohydrate Polymers1994，，30： | 1 |
| 7 | Intravenous afliberceptfor treatment of recurrent symptomatic malignant ascites inpatients with advanced ovarian cancer: a phase 2, randomised,double-blind, placebo-controlled study 显示文摘 | Gotlieb WH Amant F Advani S | 2011 | Lancet Oncol2011，13，2： | 1 |
| 8 | Infertility trealment after conservative management of borderline ovarian tumors 显示文摘 | Beiner ME Gotlieb WH Davidson B | 2001 | Cancer2001，92，2： | 1 |
| 9 | Quantifyin alfalfa yield losses caused by foliar diseases in Iowa, Ohio, Wisconsin,and Vermont 显示文摘 | Nutter F W Jr Guan J Gotlieb A R | 2002 | Plant Disease2002，86，： | 1 |
| 10 | The detrimental effect of increased endometrial thickness on implantation and pregnancy rates and outcome in an in vitro fertilization program显示文摘 | Weissman A Gotlieb L Casper RF | 1999 | Fertil Steril1999，71，1： | 1 |
| 11 | Outcome of iertility- sparing treatment with progestins in young patients with endometrial cancer显示文摘 | Gotlieb WH Beiner ME Shalmon B | 2003 | Obstet Gynecol2003，102，4： | 1 |
| 12 | Smooth muscle and endothelial cell function in the pathogenesis of atherosclerosis显示文摘 | Gotlieb AI | | 0，，： | 1 |
| 13 | Atherosclerosis and acute coronary sydromes显示文摘 | Gotlieb AI | 2005 | Cardiovasc Pathol2005，14，： | 1 |
| 14 | Genomic analyses ofprimary and metastatic serous epithelial ovarian cancer显示文摘 | Israeli O Gotlieb WH Friedman E | 2004 | Cancer Genet Cytogenet2004，154，： | 1 |
| 15 | In vitro metformin anti'neoplastic activity in epithelial ovarian cancer 显示文摘 | Gotlieb WH Sanmet J Beanchamp MC | 2008 | Gynecol Oncol2008，110，2： | 1 |
| 16 | A List Structure Form of Grammars for Syntactic Analysis显示文摘 | Doron J C Gotlieb C C | 2005 | Computing Surveys2005，2，1： | 1 |
| 17 | Doxorubicin levels in the serum and ascites of patients with ovarian cancer显示文摘 | Gotlieb WH Bruchim I Ben-Baruch G | 2007 | Eur J Surg Oncol2007，33，2： | 1 |
| 18 | Order-preserving key transformations 显示文摘 | GARG A K GOTLIEB C C | 1986 | ACM Transactions on Database Systems1986，11，2： | 1 |
| 19 | Expression of matris proteins in uterine cervical neoplasia using immunohistochemistry显示文摘 | Davidson B Goldberg L Gotlieb WH et a1 | 1998 | Eur J Obstet Gynecol Reprod Biol1998，76，1： | 1 |
| 20 | Insulin-like growth factor receptor I targeting in epithelial ovarian cancer 显示文摘 | GOTLIEB W H BRUCHIM I GU J | 2006 | Gynecol Oncol2006，100，2： | 1 |
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