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| 1 | 糖尿病诊断:界定与替换显示文摘几乎所有人群血糖浓度都是单峰分布模式,因此没有明确的分界点来确定糖尿病的诊断。老的标准为空腹血糖浓度(fasting plasma glucose,FPG)≥140mg/dl或者口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)2h血糖浓度≥200mg/dl,选择这样的标准是因为超过这些血糖值的部分病人3-8年后发生了视网膜病变。糖尿病诊断和分类专家委员会将FPG诊断标准降低到126mg/dl,使其和OGTT2h血糖浓度200mg/dl相当。过量的糖化蛋白产物在糖尿病微血管和神经并发症的病例机制中起重要作用。60%的新队列糖尿病病人,其FPG在126mg/dl-139mg/dl,且糖化血红蛋白(HbAIC)水平正常;35%的病人未用药物治疗之前就已经达到美国糖尿病学会(ADA)推荐的目标HbAl<7%。糖尿病病人维持HbAlC水平在7%以下的,6-10年之后几乎极少或者不发生视网膜病变和肾病变,或者巳有的病变不再进展。糖尿病的诊断对保险(生命和医疗),就业、社会和心理花费等均具有负面影响。此外,在糖尿病新的人群中,不论是诊断为糖尿病还是空腹血糖受损都可先予以非药物治疗,因此,以我的观点,FPG血糖标准仍应维持≥140mg/dl,除非有过量的糖化产物即HbAlC≥7%(假定上限值为6%)。依据HbAlC水平升高来诊断FPG<140mg/dl的糖尿病是和老的选择发生视网膜病变的葡萄糖浓度的诊断标准是一致的,因此建议选择性地使用初期FPG浓度加上以后糖化血红蛋白水平的流程来诊断糖尿病。学习目的:了解新推荐的糖尿病诊断中空腹血糖(FPG)标准的变化,以及这一变化导致的糖尿病“新队列”的重要意义。复习糖尿病并发症和FPG水平增高以及糖化血红蛋白(HbAlC)之间的关系。考虑临床实践中对FPG和HbAlC基本治疗可行性以及何种检测对“新队列”病人合适。 | Mayer B Davidson,MD 李玉秀 | 2001 | 世界医学杂志2001，5，10： | 3 |
| 2 | Protection of the liver by ischemic preconditioning: a review of mechanisms and clinical applications显示文摘 | Koti R S Seifalian A M Davidson B R | 2003 | Dig Surg2003，20，5： | 2 |
| 3 | ADA与EASD对2型糖尿病高血糖处理:治疗启动与评定的新共识方案显示文摘在不到一年时间由同一批专家代表ADA和EASD先后起草和发布了两次关于'2型糖尿病高血糖处理的共识声明'同时发表在2008年1月和12月的《Diabetes Care》和《Diabetologia》上。第一次共识声明内容主要围绕TZDs药物的安全性,本刊作了摘译转载(参阅《中国糖尿病杂志》2008年第7期)。第二次修订的共识声明,关注点为降糖药的新分级,论据及观点比较清晰,故仍摘译供读者参考。 | Nathan DM Buse JB Davidson MB Ferrannini E Holman RR Sherwin R Zinman B 钱荣立(摘译) | 2009 | 中国糖尿病杂志2009，17，1： | 2 |
| 4 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 5 | Anticipatory Activation in the Amygdala and Anterior Cingulate in Generalized Anxiety Disorder and Prediction of Treatment Response显示文摘 | Nitschke Jack B Sarinopoulos Issidoros Oathes Desmond J Johnstone Tom Whalen Paul J Davidson Richard J Kalin Ned H | 2009 | The American Journal of Psychiatry2009，，3： | 2 |
| 6 | Cardiovascular effects of marine omega-3 fatty acids显示文摘 | Palaniappan Saravanan Neil C Davidson Erik B Schmidt Philip C Calder | 2010 | The Lancet2010，，9740： | 2 |
| 7 | Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein显示文摘 | ERDJUMENT-BROMAGE H DAVIDSON M B | 1993 | Nature1993，362，6422： | 1 |
| 8 | RNA polymerase Ⅲ transcribes human microRNAs显示文摘 | Lanier W Davidson B L | 2006 | Nat Struct Mol Biol2006，13，12： | 1 |
| 9 | Inflammatory response in cervical intraepithelial meoplasia and squamous cell carcinoma of the uterine cervix显示文摘 | Davidson B Goldberg I Kopolovic J | 1997 | Pathol Res Praet1997，193，7： | 1 |
| 10 | Management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy显示文摘 | Nathan D M Buse J B Davidson M B | 2008 | Diabetologia2008，16，51： | 1 |
| 11 | The incidence and risk of central venous catheter malpositioning:a prospective cohort study in 1,619 patients显示文摘 | Pikwer A Baath L Davidson B | 2008 | Anaesth Intensive Care2008，36，1： | 1 |
| 12 | Whole bloodaggregation and coagulation in db/db and ob/ob mouse models of type 2 diabetes显示文摘 | Henry M L Davidson L B Wilson J E | 2008 | Blood Coagul Fibrinolysis2008，19，2： | 1 |
| 13 | CD105 (En- doglin) expression in breast carcinoma effusions is a marker of poor survival显示文摘 | Davidson B Stavnes HT Fersund M | 2010 | Breast2010，19，49： | 1 |
| 14 | Infertility trealment after conservative management of borderline ovarian tumors 显示文摘 | Beiner ME Gotlieb WH Davidson B | 2001 | Cancer2001，92，2： | 1 |
| 15 | Global bifurcation on time scales显示文摘 | DAVIDSON F A RYNNE B P | 2002 | J Math Anal Appl2002，267，1： | 1 |
| 16 | AlphaV - and betalintegrin suSunits are commonly expressed in malignant cffusions from ovarian carcinoma patients 显示文摘 | Davidson B Goldserg I Reich R | 2003 | Gynecol Oncol2003，90，： | 1 |
| 17 | E-cadherin and alpha-,beta-, and gamma-catenin protein expression is up-regulated in ovarian carcinoma cells in serous effusions显示文摘 | Davidson B Berner A Nesland JM | 2000 | J Pathol2000，192，4： | 1 |
| 18 | Earnings management and corporate governance: the role of the board and the audit committee 显示文摘 | Xie B Davidson III W N DaDatt P J | 2003 | Journal of Corporate Finance2003，9，： | 1 |
| 19 | Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice显示文摘 | Gudmundsson G Bosch A Davidson B L | 1998 | Am J Respir Cell Mol Biol1998，19，5： | 1 |
| 20 | Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans显示文摘 | SANDERS P MORTON J B DAVIDSON N C | 2003 | Circulation2003，108，： | 1 |
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