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| 1 | Epidemiological profiles of human immunodeficiency virus and hepatitis C virus infections in Malian women:Risk factors and relevance of disparities显示文摘AIM:To document the epidemiologic patterns and risk factors of human immunodeficiency virus(HIV)and hepatitis C virus(HCV)infections in Mali in order to develop prevention means for both diseases.METHODS:Two prospective studies were conducted in Bamako in 2009 among 1000 pregnant women(i.e.,young women)who consulted six reference health centers,and in 2010,among 231 older women who attended general practice in two hospitals.Antibody tests and molecular analysis(performed only for HCV)were used to quantify the frequencies of both infections.The data were collected from patients recruited through a questionnaire.Transmission risk factors of both diseases were identified by univariate and multivariate analysis.RESULTS:HCV seroprevalence was 0.2% for young and 6.5% for older women.HIV prevalence was similar in both populations(4.1% vs 6.1%).In older women,the analysis of risk factors highlighted an association between HCV infection and episodes of hospitalization(P < 0.01).The study did not show an association between HIV infection and the variables such as hospitalization,transfusion,tattoo,dental care,and endoscopy.A significant decrease of HIV seroprevalence was detected in young women who used condoms for contraception more than for other purposes(P < 0.01).By contrast,HIV seroprevalence was significantly increased in young women using condoms mainly to prevent sexual infections rather than for contraception(P < 0.01).No HCV/HIV coinfection was detected in our study.CONCLUSION:Risk factors and epidemiologic data of HIV and HCV as well as the absence of co-infection strongly suggest epidemiological disparities between these diseases. | Nouhoum Bouare Andre Gothot Jean Delwaide Sebastien Bontems Dolores Vaira Laurence Seidel Paul Gerard Christiane Gerard | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 2 | Binding and migration across fibronectin and VCAM-1 of cycling hematopoietic progenitor cells显示文摘 | Gothot A Giet O Huygen S | 2003 | Leuk Lymphoma2003，44，8： | 1 |
| 3 | Clinical use of D-dimer testing 显示文摘 | Lachatre F Gothot A | 2007 | Rev Med Liege2007，62，1： | 1 |
| 4 | Role of stromal-derived factor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells显示文摘 | Van OS Beguin Y Gothot A | 2006 | Eur J Heamatol2006，76，6： | 1 |
| 5 | Clinical use of D-dimer testing显示文摘 | Lachtre F Gothot A | 2007 | Rev Med Liege2007，62，1： | 1 |
| 6 | Binding and migration across fibronectin and VCAM-1 of cycling hematopoietic progenitor cells显示文摘 | Gothot A Giet O Huygen S | 2003 | Leuk Lymphoma2003，44，8： | 1 |
| 7 | Role of stromal- derived factor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells显示文摘 | Van-Overstraeten-Schlogel N Beguin Y Gothot A | 2006 | Eur J Heamatol2006，76，6： | 1 |
| 8 | Comparison of the platelet concentrations obtained in platelet-rich plasma (PRP) between the GPS? II and GPS? III systems显示文摘 | J.-F. Kaux C. Le Goff J. Renouf P. Peters L. Lutteri A. Gothot J.-M. Crielaard | 2010 | Pathologie Biologie2010，，5： | 1 |
| 9 | Binding and migration across fibronectin and VCAM - 1 of cycling hematopoietic progenitor cells 显示文摘 | Gothot A Giet O Huygen S | 2003 | Leuk Lymphoma2003，44，8： | 1 |
| 10 | Cell cycle - relatedchanges in repopulating capacity of human mobilized peripheralblood CD34( + ) cells in non - obese diabetic/severe combinedimmune - deficient mice显示文摘 | Gothot A van der Loo JC Clapp DW | 1998 | Blood1998，92，： | 1 |
| 11 | Role of stromal-derived factor-Ⅰ in the hematopoietic-supporting activity of human mesenchymal stem cells显示文摘 | Van Overstraeten-Schlogel N Beguin Y Gothot A | 2006 | Eur J Haematol2006，76，6： | 1 |
| 12 | Mesenehymal stem cells: a new versatile therapeutic option显示文摘 | Baron F Gothot A | 2007 | Rev Med Liege2007，62，： | 1 |
| 13 | Role of stromal-derived factor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells 显示文摘 | Van Overstraeten-Schlogel N Beguin Y Gothot A | 2006 | Eur J Haematol2006，76，6： | 1 |
| 14 | Role of stromal-derived fac- tor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells 显示文摘 | Van OS Beguin Y Gothot A | 2006 | Eur J Heamatol2006，76，6： | 1 |
| 15 | Functional heterogeneity of human CD34+ cells isolated in subcompartments of the G0/G1 phase of the cell cycle显示文摘 | Pyatt R McMahel J | 1997 | Blood1997，90，： | 1 |
| 16 | 在 Malian 女人和血清学的试金表演的二张人口的 HIV 和 HCV 感染的流行显示文摘 AIM:To estimate the prevalence of human immunodeficiency virus(HIV) and hepatitis C virus(HCV) infections in women in Mali and to evaluate the performance of serological assays.METHODS:Two prospective studies were conducted in 2009 and 2010 in Mali.They concerned first,1000 pregnant women attending six reference health centers in Bamako(Malian capital) between May 26 and June 16,2009;and secondly,231 women over 50 years who consulted general practitioners of two hospitals in Bamako between October 25 and December 24,2010.Blood samples were collected and kept frozen in good condition before analysis.All samples depicted as positive using HIV/HCV enzyme immuno-assay screening assays were submitted to confirmation analysis.Molecular markers of HCV were characterized.RESULTS:The seroprevalence of HIV and HCV in the population of pregnant women was 4.1% and 0.2% respectively.Among older women the seroprevalence was higher and similar for HIV and HCV(6.1% vs 6.5%).The anti-HIV prevalence was not different in young and older women(4.1% vs 6.1%).In contrast,the anti-HCV prevalence was higher in older compared to younger women(6.5% vs 0.2%,P < 0.01).Of 2 pregnant women who were HCV seropositive,only one was polymerase chain reaction(PCR) reactive and infected by genotype 2,with a viral load of 1600 IU/mL.Regarding older women who were HCV seropositive,13 out of 15 were PCR reactive,infected by genotype 1 or 2.Globally HCV genotype 2 was predominant.The positive predictive value(PPV) measured with VIKIA HIV test in young women was 100% therefore significantly higher than the 87.5% measured in older women(P < 0.05).Conversely,the PPV measured with Monolisa HCV assay in older women was 88.2% and higher than the 14.3% measured in younger women(P < 0.01).CONCLUSION:Whereas HIV prevalence was similar in both subpopulations HCV was more frequent among older women(P < 0.01).The PPV of screening assays varied with the age of the subjects. | Nouhoum Bouare Dolores Vaira Andre Gothot Jean Delwaide Sebastien Bontems Laurence Seidel Paul Gerard Christiane Gerard | 2012 | World Journal of Hepatology2012，4，12： | 1 |
| 17 | Mature erythrocyte parameters as new markers of functional iron deficiency in haemodialysis:sensitivity and specificity显示文摘 | Bovy C Gothot A Delanaye P | | 0，，04： | 1 |
| 18 | Functional heterogeneity of human CD34 (+) cells isolated in subcompartments of the G0 /G1 phase of the cell cycle 显示文摘 | Gothot A Pyatt R McMahel J | 1997 | Blood1997，90，11： | 1 |
| 19 | Role of stromal-derived factor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells显示文摘 | BEGUIN Y GOTHOT A | 2006 | Eur J Heamatol2006，76，6： | 1 |
| 20 | Clinical use of D-dimer testing显示文摘 | Laehatre F Gothot A | 2007 | Rev Med Liege2007，62，1： | 1 |
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