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| 1 | Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model. | Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss | 2008 | World Journal of Gastroenterology2008，14，44： | 4 |
| 2 | Long-ter m greenhouse gas emissions from hydroelectric reservoirs in tropical forest regions显示文摘 | Galy-Lacaux C Delmas R Kouadio G Richard S Gosse P | 1999 | Global Biogeochemical Cycles1999，13，2： | 2 |
| 3 | Get a grip on patientsafety: outcomes in the palm of your hand显示文摘 | Goss L Carrico R | 2002 | J Infus Nurs2002，25，4： | 1 |
| 4 | Threat Perception in Product Harm Crises:Do Older Consumers Feel More Vulnerable?显示文摘 | Silvera D H Meyer T Laufer D Goss R J Arsena A R | 2010 | Advances in Consumer Research2010，37，： | 1 |
| 5 | Blood pressure surge on rising显示文摘 | Lasserre R Minifie C | 2004 | JHypertens2004，22，6： | 1 |
| 6 | Orthotopic liver transplantation for primary sclerosing chlolangitis:a 12-year single experience显示文摘 | Goss J A Shackleton C R Farmer D G | 1997 | Ann Surg1997，225，： | 1 |
| 7 | Get a grip on patient safety: outcomes in the palm of your hand显示文摘 | GOSS L CARRICO R | 2002 | J Infus Nurs2002，25，4： | 1 |
| 8 | What drives health spending in theNorthern Territory显示文摘 | Zhao Y J Goss J Malyon R | 2010 | Economic Papers2010，29，3： | 1 |
| 9 | Blood pressure surge on rising显示文摘 | Gosse P Lasserre R Minifie C | 2004 | Hypertens2004，22，6： | 1 |
| 10 | Role of hexagonal structure-forming lipids in diadinoxanthin and violaxanthin solubilization and de-epoxidation显示文摘 | GOSS R LOHR M LATOWSKI D | 2005 | Biochemistry2005，44，： | 1 |
| 11 | Trinexapac-ethyl arm ni- trogen effects on creeping bentgrass grown under reduced light conditions 显示文摘 | Goss R M Baird J H Kelm S L | 2002 | Crop Science2002，42，2： | 1 |
| 12 | A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in seeond-line therapy of advanced non-small cell lung cancer ( GALAXY-1 ) 显示文摘 | Ramalingam S Goss G Rosell R | 2015 | Ann Oncol2015，26，8： | 1 |
| 13 | A new species-specific nuclear DNA marker for identification of hybrids between Atlantic salmon and brown Trout 显示文摘 | Goss R Nilsson J Schmitz M | 1996 | Journal of Fish Biology1996，49，： | 1 |
| 14 | Randomized phase U study of Gefitinib compared With placebo in chemotherapy- naive patients with advanced non-small-cell lung cancer and poor performance status显示文摘 | Goss G Ferry D Wierzbicki R | 2009 | J Clin Oncol2009，27，13： | 1 |
| 15 | Blood pressure surge on rising 显示文摘 | Gosse P Lasserre R Minifi C | 2004 | J Hypertens2004，22，6： | 1 |
| 16 | Blood pressure surge on rising显示文摘 | Gosse P Lasserre R Minifi6 C | 2004 | JHypertens2004，22，6： | 1 |
| 17 | Phase 2 trial of Linifanib (ABT-869) in patients with advaneed non- small cell lung cancer 显示文摘 | Tan E H Goss G D Salgia R | 2011 | J Thorac Oncol2011，6，8： | 1 |
| 18 | Addressing the difficulties in using inductive methods to evaluating human body composition显示文摘 | Peyton A J Mackin R Goss D | 2003 | Biometrie Humaine at Anthropologie2003，21，： | 1 |
| 19 | Challenges to effective cancer control in China, India, and Russia显示文摘 | Paul E Goss Kathrin Strasser-Weippl Brittany L Lee-Bychkovsky Lei Fan Junjie Li Yanin Chavarri-Guerra Pedro E R Liedke C S Pramesh Tanja Badovinac-Crnjevic Yuri Sheikine Zhu Chen You-lin Qiao Zhiming Shao Yi-Long Wu Daiming Fan Louis W C Chow Jun Wang Qio | 2014 | Lancet Oncology2014，，5： | 1 |
| 20 | The reinvention roller coaster:Risking the present for a powerful future显示文摘 | Pascale R Goss T | 1993 | Harvard Business Review1993，71，6： | 1 |
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