|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells显示文摘Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen(CTLA)-4/B7 interaction(using CTLA-4Ig) and the CD40/CD40 L interaction(using anti-CD40 L antibodies) prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid arthritis(abatacept) and to prevent rejection of renal transplants(belatacept). Under certain experimental conditions, this treatment can even result in tolerance. Surprisingly, the underlying mechanisms of immune modulation are still not completely understood. We here discuss the evidence that costimulation blockade differentially affects effector T cells(Teff) and regulatory T cells(Treg). The latter are required to control inappropriate and unwanted immune responses, and their activity often contributes to tolerance induction and maintenance. Unfortunately, our knowledge on the costimulatory requirements of Treg cells is very limited. We therefore summarize the current understanding ofthe costimulatory requirements of Treg cells, and elaborate on the effect of anti-CD40 L antibody and CTLA-4Ig treatment on Treg cell activity. In this context, we point out that the outcome of a treatment aiming at blocking the CD28/CTLA-4/B7 costimulatory interaction can vary with dosing, timing and underlying immunopathology. | Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens | 2014 | World Journal of Immunology2014，4，2： | 3 |
| 2 | The neu-roinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease:therapeutic implications显示文摘 | ROZEMULLER A J GOOL W A EIKELENBOOM P | 2005 | Current Drug Targets-CNS Neuro Dis2005，4，2： | 1 |
| 3 | Dendritic cel therapy of high-grade gliomas显示文摘 | Van Gool S Maes W Ardon H | | 0，，04： | 1 |
| 4 | Cytochrome P-450:target for itraconazole显示文摘 | Bellens D Gools W | 1987 | Drug Dev Res1987，8，： | 1 |
| 5 | Dendritic ceil therapy of high-grade gliomas显示文摘 | Van Gool S Maes W Ardon H | 2009 | Brain Pathol2009，19，4： | 1 |
| 6 | The effects of analgesic prescription and patient adherence on pain in a Duch outpatient cancer population 显示文摘 | Enting R Oldenmenger W van Gool A | 2007 | J Pain Sympt Manage2007，34，15： | 1 |
| 7 | Interaction of CTLA-4(CD152) with CD80 or CD86 inhibits human T-cell activation显示文摘 | Vandenborre K Van Gool S W Kasran A | 1999 | Immunology1999，98，3： | 1 |
| 8 | Systemic infection and delirium : when cytokines and acetylcholine collide显示文摘 | VAN GOOL W A VAN DE BEEK D E1KELENBOOM P | 2010 | Lancet2010，375，9716： | 1 |
| 9 | A survey of urban reconstruction显示文摘 | MUSIALSKI P WONKA P A sc liaga D G WIMMER M GOOL L PURGATHOFER W | 2013 | Computer Graphics Forum2013，32，6： | 1 |
| 10 | Oral essential fatty acid supplementation in atopic dermatitis --a meta-analysis of placebocontrolled trials显示文摘 | Van Gool C J A W Zeegers M P A Thijs C | 2004 | British J Dermatol2004，150，： | 1 |
| 11 | Sys- temic infection and delirium:when cytokines and acetylcho- line collide 显示文摘 | van GOOL W A van de BEEK D EIKELENBOOM P | 2010 | Lancet2010，375，： | 1 |
| 12 | The preparation of new isoflavones显示文摘 | SILVIA S B GOOL H W MARCOS C R | 2001 | Synth Commun2001，31，12： | 1 |
| 13 | The effects of excipi- ents on transporter mediated absorption显示文摘 | GOOLE J LINDLEY DJ ROTH W | 2010 | Int J Pharm2010，393，1： | 1 |
| 14 | Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model显示文摘 | Maes W van Gool SW | 2011 | Cancer Immunol Immunother2011，60，2： | 1 |
| 15 | Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model 显示文摘 | Maes W Van Gool SW | 2013 | Cancer Immunal Immunother2013，60，2： | 1 |
| 16 | CD80,CD86 and CD40 provide accessory singals in a multiple-step T-cell activation model 显示文摘 | VAN GOOL S W VANDENBEREGHE P DE BORE M | 1996 | Immunol Rev1996，153，： | 1 |
| 17 | Credit Scoring for Microfinance: Is It Worth It? 显示文摘 | Baesens B Verbeke W Sercu P and Gool J V | 2011 | national Journal of Finance and Economics2011，17，2： | 1 |
| 18 | Possible use of surface migration in fuel cells and heterogeneous catalysis 显示文摘 | GOOL W V | 1965 | Phillips Res Repts1965，20，： | 1 |
| 19 | Systemic infection and delirium: when cytokines and acetylcholine collide显示文摘 | Van Gool W A Van de Beek D Eikelenboom P | 2010 | Lancet2010，375，： | 1 |
| 20 | Experimental immunotherapy formalignant glioma:lessons from two decades of research in theGL261model显示文摘 | Maes W Van Gool SW | 2011 | Cancer Immunol Immunother2011，60，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员