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| 1 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 2 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 3 | Nitrogen mineralization in paddy soils of the Chinese Taihu region under aerobic con- ditions 显示文摘 | MARCO R HAN Y CAI Z C | 2002 | Nutrient Cycling in Agroecosystems2002，63，23： | 1 |
| 4 | Combined intemal uncusectomy and decompressive craniectomy for the treatment of severe closed head injury: experience with 80 cases 显示文摘 | SALVATORE C MARCO M ANTONIO R | 2008 | J Neurosurg2008，108，1： | 1 |
| 5 | CD16^+ human monocyte-derived dendritic cells matured with different and unrelated stimuli promote similar allogeneic Th2 responses: regulation by pro- and anti-inflammatory cytokines显示文摘 | Amaranta C Marco A Meraz R | 2004 | International Immunology2004，16，9： | 1 |
| 6 | Pattern recognition approach to robust voiced/unvoiced speech classification using fuzzy logic显示文摘 | Salvatore C Marco R | 1999 | Int J Pattern Recog ArtifIntell1999，13，1： | 1 |
| 7 | Quantitative determination of fatty acid chain composition in pork meat products by high resolution 1H NMR spectroscopy显示文摘 | SICILIANO C BELSITO E de MARCO R | 2013 | Food Chemistry2013，136，： | 1 |
| 8 | Experimental boiling heat transfer coefficients in the high temperature generator of a double effect absorption machine for the lithium bromide/water mixture 显示文摘 | MARCOS J D IZQUIERDO M LIZARTE R PALACIOS E INFANTE F C A | 2009 | International Journal of Refrigeration2009，32，： | 1 |
| 9 | The role of prefrontal cortex in verbal episodic memory: rTMS evidence显示文摘 | Marco S Stefano F C Simone R | 2003 | Journal of Cognitive Neuroscienee2003，15，6： | 1 |
| 10 | Optimal spanwise chord and thickness distribution for a Troposkien Darrieus wind turbine显示文摘 | GABRIELE B MARCO R C ERNESTO B | 2014 | Journal of Wind Engineering and Industrial Aerodynamics2014，125，： | 1 |
| 11 | Parallel CRC realization 显示文摘 | GIUSEPPE C GIUSEPPE P MARCO R | 2003 | IEEE Transactions on Computers2003，52，10： | 1 |
| 12 | Boundary crises, fractal basin boundaries and electric power collapses 显示文摘 | Marcos S H C Lopes S R Viana R L | 2003 | Chaos Solutions and Fractals2003，15，2： | 1 |
| 13 | Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms显示文摘 | Emmanuele C Marco R Samantha Z | 2010 | Bioorg Med Chem2010，18，11： | 1 |
| 14 | Combined internal uncusec- tomy and decompressive eraniectomy for the la'eatment of 8eveIt closed head injury: experience with 80 cases 显示文摘 | Salvatore C Marco M Antonio R | 2008 | J Neurosurg2008，108，1： | 1 |
| 15 | Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity ofnew tacrine-like analogues显示文摘 | Marco J L Delos R C Carreiras M C | 2001 | Bioorg Med Chem2001，9，3： | 1 |
| 16 | Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents 显示文摘 | Marco R Emmanuele C Giorgia B | 2008 | Bioorg Med Chem Lett2008，18，3： | 1 |
| 17 | Premature lung aging and cellularsenescence in the pathogenesis of idiopathic pulmonary fibrosis andCOPD/emphysema显示文摘 | Marco C Angelo C Andrea R | 2013 | Translational Research2013，162，3： | 1 |
| 18 | Dynamic crystallization of polypropylene and wood-based composites显示文摘 | BOUZA R MARCO C MARTIN Z | 2006 | J Appl Polym Sci2006，102，6： | 1 |
| 19 | Combined internal uncusec- tomy and decomprcssive craniectomy for the treatment of sever closed head injury: experience with 80 cases 显示文摘 | Salvatore C Marco M Antonio R | 2008 | J Ncurosurg2008，108，1： | 1 |
| 20 | Development of an horizontal interferometric dilatometer for gauge blocks显示文摘 | Marcos M R | 2005 | Proceedings of SPIE2005，5576，： | 1 |
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