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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | New advances in targeted gastric cancer treatment显示文摘Despite a decrease in incidence over past decades,gastric cancer remains a major global health problem. In the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic techniques, surgical and chemotherapeutic approaches, the development of novel therapeutic agents and treatment by multidisciplinary teams. Because multiple genetic mutations, epigenetic alterations, and aberrant molecular signalling pathways are involved in the development of gastric cancers, recent research has attempted to determine the molecular heterogeneity responsible for the processes of carcinogenesis, spread and metastasis. Currently, some novel agents targeting a part of these dysfunctional molecular signalling pathways have already been integrated into the standard treatment of gastric cancer, whereas others remain in phases of investigation within clinical trials. It is essential to identify the unique molecular patterns of tumours and specific biomarkers to develop treatments targeted to the individual tumour behaviour. This review analyses the global impact of gastric cancer, as well as the role of Helicobacter pylori infection and the efficacy of bacterial eradication in preventing gastric cancer development. Furthermore, the paper discusses the currently available targeted treatments and future directions of research using promising novel classes of molecular agents for advanced tumours. | Daniela Cornelia Lazar Sorina Taban Marioara Cornianu Alexandra Faur Adrian Goldis | 2016 | World Journal of Gastroenterology2016，22，30： | 15 |
| 3 | Malignant hepatic vascular tumors in adults: Characteristics,diagnostic difficulties and current management显示文摘Malignant vascular tumors of the liver include rare primary hepatic mesenchymal tumors developed in the background of a normal liver parenchyma. Most of them are detected incidentally by the increased use of performing imaging techniques. Their diagnosis is challenging, involving clinical and imaging criteria, with final confirmation by histology and immunohistochemistry. Surgery represents the mainstay of treatment. Liver transplantation(LT) has improved substantially the prognosis of hepatic epithelioid hemangioendothelioma(HEHE), with 5-year patient survival rates of up to 81%, based on the European Liver Intestine Transplantation AssociationEuropean Liver Transplant Registry study. Unfortunately, the results of surgery and LT are dismal in cases of hepatic angiosarcoma(HAS). Due to the disappointing results of very short survival periods of approximately 6-7 mo after LT, because of tumor recurrence and rapid progression of the disease, HAS is considered an absolute contraindication to LT. Recurrences after surgical resection are high in cases of HEHE and invariably present in cases of HAS. The discovery of reliable prognostic markers and the elaboration of prognostic scores following LT are needed to provide the best therapeutic choice for each patient.Studies on a few patients have demonstrated the stabilization of the disease in a proportion of patients with hepatic vascular tumors using novel targeted antiangiogenic agents, cytokines or immunotherapy. These new approaches,alone or in combination with other therapeutic modalities, such as surgery and classical chemotherapy, need further investigation to assess their role in prolonging patient survival. Personalized therapeutic algorithms according to the histopathological features, behavior, molecular biology and genetics of the tumors should be elaborated in the near future for the management of patients diagnosed with primary malignant vascular tumors of the liver. | Daniela Cornelia Lazar Mihaela Flavia Avram Ioan Romosan Violetta Vacariu Adrian Goldis Marioara Cornianu | 2019 | World Journal of Clinical Oncology2019，10，3： | 7 |
| 4 | Tumor-Targeted Gene Delivery Using Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles: In Vitro and in Vivo Studies显示文摘 | Goldie Kaul Mansoor Amiji | 2005 | Pharmaceutical Research2005，，6： | 2 |
| 5 | Predictors of rebleeding and in-hospital mortality in patients with nonvariceal upper digestive bleeding显示文摘BACKGROUND Nonvariceal upper digestive bleeding (NVUDB) represents a severe emergency condition and is associated with significant morbidity and mortality. Despite a decrease in the incidence due to the widespread use of potent therapy with proton pump inhibitors as well as the implementation of modern endoscopic techniques, the mortality rate associated with NVUDB is still high. AIM To identify the clinical, biological, and endoscopic parameters associated with a poor outcome in patients with NVUDB to allow the stratification of risk, which will lead to the implementation of the most accurate management. METHODS We performed a retrospective study including patients who were admitted to the Gastroenterology Department of Clinical Emergency County Hospital Timisoara, Romania, with a diagnosis of NVUDB between 1 January 2008 and 31 December 2016. All the data were collected from the patient’s records, including demographic data, medication history, hemodynamic status, paraclinical tests, and endoscopic features as well as the methods of hemostasis, rate of rebleeding, need for surgery and death;we also assessed the Rockall score of the patients, length of hospitalization and associated comorbidities. All these parameters were evaluated as potential risk factors associated with rebleeding and death in patients with NVUDB.RESULTS We included a batch of 1581 patients with NVUDB, including 523 (33%) females and 1058 (67%) males with a median age of 66 years. The main cause of NVUDB was peptic ulcer (73% of patients). More than one-third of the patients needed endoscopic treatment. Rebleeding rate was 7.72%;surgery due to failure of endoscopic hemostasis was needed in 3.22% of cases;the in-hospital mortality rate was 8.09%, and the bleeding-episode-related mortality rate was 2.97%. Although our predictive models for rebleeding and death had a low sensitivity, the specificity was very high, suggesting a better discriminative capacity for identifying patients with better outcomes. Our results showed that the Rockall score was associated with both rebleeding and death;comorbidities such as respiratory conditions, liver cirrhosis and sepsis increased significantly the risk of in-hospital mortality (OR of 3.29, 2.91 and 8.03). CONCLUSION Our study revealed that the Rockall score, need for endoscopic therapy, necessity of transfusion and sepsis were risk factors for rebleeding. Moreover, an increased Rockall score and the presence of comorbidities were predictive factors for inhospital mortality. | Daniela Cornelia Lazar Sorin Ursoniu Adrian Goldis | 2019 | World Journal of Clinical Cases2019，7，18： | 2 |
| 6 | Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis显示文摘 | BEAUX A C GOLDIE A S ROSS J A | 1996 | Br J Surg1996，83，3： | 1 |
| 7 | Human papillomavirus and HPV vaccines:a review显示文摘 | Cutts FT Franceschi S Goldie S | 2007 | Bulletin of the World Health Organization2007，85，： | 1 |
| 8 | The clinical effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men显示文摘 | Goldie SJ Kuntz KM Weinstein MC | 1999 | JAMA1999，281，19： | 1 |
| 9 | A mathematical model for relating the drug sensitivity of tumors to their spontaneous mutation rate显示文摘 | Goldie JH Coldman AJ | 1979 | Cancer Treat Rep1979，63，13： | 1 |
| 10 | Patients' experiences of readiness for discharge following a total hip replacement显示文摘 | Heine J Koch S Goldie P | 2004 | Aust J Physiother2004，50，4： | 1 |
| 11 | Human papiloma - virus and HPV vaccines 显示文摘 | Cutts 3' Franceschi S Goldie S | 2007 | B World Health Organ2007，85，9： | 1 |
| 12 | Distributions that are both subexponential and in the domain of an extreme-value distribution显示文摘 | Goldie C M Resnick S | 1988 | Adv Appl Probab1988，20，： | 1 |
| 13 | FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis显示文摘 | Goldie SJ Mulder KW Tan DW | | 0，，13： | 1 |
| 14 | Natural cytokine antagonists and endogenous antiendotoxin core antibodies in seosis syndrome显示文摘 | Goldie AS Fearon KCH Ross JA | 1995 | JAMA1995，274，2： | 1 |
| 15 | Human papillomavirus and HPV vaccines:A review显示文摘 | Cutts FT Franceschi S Goldie S | 2007 | Bull World Health Organ2007，85，9： | 1 |
| 16 | Serum concentration of inflammatory mediators related to organ failure in patients with actue pancreatitis显示文摘 | Braux AC Goldie AS Ross JA | 1996 | British J Surg1996，83，4： | 1 |
| 17 | Regulation of endothelial cell differentiation and specification显示文摘 | Marcelo KL Goldie LC Hirschi KK | 2013 | Circ Res2013，112，9： | 1 |
| 18 | Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation 显示文摘 | Kolaezkowska E Goldys A Kozakiewiez E | 2009 | Arch Immunol Ther Exp (Warsz)2009，57，6： | 1 |
| 19 | Promoter activity in the 5' flanking regions of the Bohle iridovirus ICP18, ICP46 and major capsid protein genes 显示文摘 | Pallister J Goldie S Coupar B | 2005 | Arch Viro2005，150，8： | 1 |
| 20 | Epidural anesthesia in low - back pain and sciatica 显示文摘 | Goldie I Peterhoff V | 1968 | Acta Orthop Scand1968，39，： | 1 |
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