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| 1 | Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in ratsPentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats显示文摘BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion disturbances.BPC 157 was previously reviewed as novel mediator of Robert cytoprotection and endothelium protection in the stomach,and gut-brain axis,beneficial therapy in gastrointestinal tract,with particular reference to vascular recruitment,ulcerative colitis and tumor cachexia,and other tissues healing.Here we raised new hypothesis about BPC 157 therapy in the Budd-Chiari syndrome in rats,rapid bypassing of the suprahepatic inferior caval vein occlusion,and rats recovery with the active and effective pharmacotherapy treatment.AIM To investigate Budd-Chiari syndrome model(inferior caval vein suprahepatic occlusion)resolution,since BPC 157 resolves various rat vascular occlusion.METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt,counteracted caval/portal hypertension,aortal hypotension,venous/arterial thrombosis,electrocardiogram disturbances,liver and gastrointestinal lesions(i.e.,stomach and duodenum hemorrhages,in particular,congestion).Rats with suprahepatic occlusion of the inferior vena cava by ligation were medicated at 1 min,15 min,24 h,or 48 h post-ligation.Medication consisted of 10μg/kg BPC 157,10 ng BPC 157 or 5 m L/kg saline,administered once as an abdominal bath or intragastric application.Gross and microscopic observations were made,in addition to assessments of electrical activity of the heart(electrocardiogram),portal and caval hypertension,aortal hypotension,thrombosis,hepatomegaly,splenomegaly and venography.Furthermore,levels of nitric oxide,malondialdehyde in the liver and serum enzymes were determined.RESULTS BPC 157 counteracted increased P wave amplitude,tachycardia and ST-elevation,i.e.,right heart failure from acute thrombotic coronary occlusion.The bypassing pathway of the inferior vena cava-azygos(hemiazygos)vein-superior vena cava and portocaval shunt occurred rapidly.Even with severe caval portal hypertension,BPC 157 antagonized portal and caval hypertension and aortal hypotension,and also reduced refractory ascites.Thrombosis of portal vein tributaries,inferior vena cava,and hepatic and coronary arteries was attenuated.In addition,there was reduced pathology of the lungs(severe capillary congestion)and liver(dilated central veins and terminal portal venules),decreased intestine hemorrhagic lesions(substantial capillary congestion,submucosal edema and architecture loss),and increased liver and spleen weight.During the period of ligation,nitric oxide-and malondialdehyde-levels in the liver remained within normal healthy values,and increases in serum enzymes were markedly reduced.CONCLUSION BPC 157 counteracts Budd Chiari syndrome in rats. | Slaven Gojkovic Ivan Krezic Borna Vrdoljak Dominik Malekinusic Ivan Barisic andreja Petrovic Katarina Horvat Pavlov Marijan Kolovrat Antonija Duzel Mario Knezevic Katarina Kasnik Kovac Domagoj Drmic Lovorka Batelja Vuletic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric | 2020 | World Journal of Gastrointestinal Pathophysiology2020，11，1： | 2 |
| 2 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 3 | Less theory and more action? The state of international prison mental health care显示文摘 | Gojkovic D | 2010 | Int J Nurs Stud2010，47，2： | 1 |
| 4 | Kinetic study of methanol oxidation on carbon-suppcrtod PtRu electroeatalyst显示文摘 | Gojkovic S L Vidakovic T R Durovie D R | 2003 | Electrochimica Acta2003，48，： | 1 |
| 5 | Oxygen reduction on iron: part VII: temperature dependence of oxygen reduction on passivated iron in alkaline solution显示文摘 | Gojkovic S L Zecevic S K Drazic D M | 1995 | J Electroanalytical Chemistry1995，399，12： | 1 |
| 6 | The properties of carbon supported hydrous ruthenium oxide obtained from RuOxHy sol显示文摘 | V PANIC T VIDAKOVIC GOJKOVIC S S | 2003 | Electrochimica Acta2003，，48： | 1 |
| 7 | Kinetic study of methanol oxidation on carbon-supported PtRu electrocatalyst显示文摘 | Gojkovic S L Vidakovid T R Durovic D R | 2003 | Electrochimica Acha2003，48，24： | 1 |
| 8 | Nb-doped Ti02 as a Support of Pt and Pt-Ru Anode Catalyst for PEMFCs 显示文摘 | Gojkovic' SL Babic' BM Radmilovic' | 2010 | Electroanal Chem2010，639，12： | 1 |
| 9 | Simutaneous Determination of Phenol显示文摘 | ZECEVIC S DRAZIC D M GOJKOVIC S | 1988 | Electrochemistry1988，53，12： | 1 |
| 10 | Pentadecapeptide BPC 157 resolves Pringle maneuver in rats,both ischemia and reperfusion显示文摘BACKGROUND The Pringle maneuver[portal triad obstruction(PTO)]provides huge disturbances during ischemia and even more thereafter in reperfusion.Contrarily,a possible solution may be stable gastric pentadecapeptide BPC 157,with already documented beneficial effects in ischemia/reperfusion conditions.Recently,BPC 157,as a cytoprotective agent,successfully resolved vessel occlusions in rats(ischemic colitis;deep vein thrombosis,superior anterior pancreaticoduodenal vein;bile duct cirrhosis)through rapid collateral vessel recruitment to circumvent vessel occlusion.Thereby,medication BPC 157 regimens were administered as a single challenge before and during ischemia or,alternatively,at various time points during reperfusion.AIM To introduce BPC 157 therapy against pringle maneuver-damage.METHODS In deeply anesthetised rats,the portal triad was clamped up for 30 min.Rats then underwent reperfusion for either 15 min or 24 h.Medication[(10μg,10 ng/kg)regimens,administered as a single challenge]picked(a)ischemia,PTO period[at 5 min before(ip)or at 5 or 30 min of ligation time(as a bath to PTO)]or(b)reperfusion,post-PTO period[at 1 or 15 min(bath during surgery)or 24 h(ip)reperfusion-time].We provided gross,microscopy,malondialdehyde,serum enzymes,electrocardiogram,portal,caval,and aortal pressure,thrombosis and venography assessments.RESULTS BPC 157 counteracts electrocardiogram disturbances(increased P wave amplitude,S1Q3T3 QRS pattern and tachycardia).Rapidly presented vascular pathway(portal vein-superior mesenteric vein-inferior mesenteric vein-rectal veins-left ileal vein-inferior caval vein)as the adequate shunting immediately affected disturbed haemodynamics.Portal hypertension and severe aortal hypotension during PTO,as well as portal and caval hypertension and mild aortal hypotension in reperfusion and refractory ascites formation were markedly attenuated(during PTO)or completely abrogated(reperfusion);thrombosis in portal vein tributaries and inferior caval vein or hepatic artery was counteracted during portal triad obstruction PTO.Also,counteraction included the whole vicious injurious circle[i.e.,lung pathology(severe capillary congestion),liver(dilated central veins and terminal portal venules),intestine(substantial capillary congestion,submucosal oedema,loss of villous architecture),splenomegaly,right heart(picked P wave values)]regularly perpetuated in ischemia and progressed by reperfusion in Pringle rats.CONCLUSION BPC 157 resolves pringle maneuver-damage in rats,both for ischemia and reperfusion. | Marijan Kolovrat Slaven Gojkovic Ivan Krezic Dominik Malekinusic Borna Vrdoljak Katarina Kasnik Kovac Tamara Kralj Domagoj Drmic Ivan Barisic Katarina Horvat Pavlov Andreja Petrovic Antonija Duzel Mario Knezevic Ivan Mirkovic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric | 2020 | World Journal of Hepatology2020，12，5： | 1 |
| 11 | Heat-treated iron (Ⅲ) tetramethoxyphenyl porphyrin supported on high-area carbon as an electrocatalyst for oxygen reductin 显示文摘 | Gojkovic S Lj Gupta S Savinell R F | 1998 | J Electrochem Soc1998，145，： | 1 |
| 12 | Hydrogen evolution at Zn Ni alloys 显示文摘 | STEVANOVIC J GOJKOVIC S DESPIC A OBRADOVIC M NAKIC V | 1998 | Electrochim Acta1998，43，： | 1 |
| 13 | Methanol oxidation on an ink type electrode using Pt supported on high area carbons显示文摘 | Gojkovic S L Vidakovic T R | 2001 | Elec- trochim Acta2001，47，4： | 1 |
| 14 | Numerical and experimental investigation of backdraft显示文摘 | HORVAT A SINAI Y GOJKOVIC D | 2007 | Combustion Science and Technology2007，180，1： | 1 |
| 15 | Mixtures of methanol and 2-propanol as a potential fuel for direct alcohol fuel cells显示文摘 | GOJKOVIC S L TRIPKOVIC A V STEVANOVIC R M | | 0，，12： | 1 |
| 16 | Heat-treated iron (Ⅲ)tetramethoxyphenyl porphydn supported on high-area carbon as an electrocatalyst for oxygen reduction显示文摘 | GOJKOVIC S L J GUPTA S SAVINELL R F | 1998 | J Elecreoehem Soc1998，145，： | 1 |
| 17 | Study of formic acid oxidation on carbon-supported platinum electrocatalyst 显示文摘 | LOVIC J D TRIPKOVIC A V GOJKOVIC S L | 2005 | Journal of Eleetroanalyst Chemistry2005，581，2： | 1 |
| 18 | The properties of carbon-supported hydrous ruthenium oxide obtained from RuOxHy sol显示文摘 | Panic V Vidakovic T Gojkovic S | 2003 | Electrochim Acta2003，48，： | 1 |
| 19 | Hydrogen evolu- tion at Zn - Ni Alloys 显示文摘 | Stevanovic J Gojkovic S Despic A | 1998 | Electrochimica Acta1998，43，7： | 1 |
| 20 | Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts 显示文摘 | Gojkovic Z Knecht W Zameitat E | 2004 | Molecular Genetics and Genomics2004，271，4： | 1 |
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