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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Cavitation and failure during hot forging of Ti-6A1-4V显示文摘 | Semiatin S L Goetz R L Shell E B | 1999 | Metallurgical and Materials Transactions1999，，： | 1 |
| 3 | Enforcing promises : an examination of the basis of contract 显示文摘 | CHARLES J GOETZ ROBERT E SCOTt | 1980 | The Yale Law Journal1980，89，7： | 1 |
| 4 | ATM-dependent IGF-1induction regulates secretory clusterin expression after DNA damage and in genetic instability显示文摘 | Goetz E M Shankar B Zou Y | 2011 | Oncogene2011，30，35： | 1 |
| 5 | Theory of Mind and Psychoses 显示文摘 | Doody G A Goetz M Johnstone E C | 1998 | Psychological Medicine1998，28，： | 1 |
| 6 | Image spectrometry for earth remote sensing 显示文摘 | Goetz Alexander F H Vane G Solomon J E | 1985 | Science1985，228，4704： | 1 |
| 7 | Possible near-IR channels for remote sensing precipitable water vapor from geostationary satellite platforms显示文摘 | Gao B C Goetz A F Westwater E R | 1993 | J Appl Meteor1993，32，12： | 1 |
| 8 | Short-term and practice effects of metronome pacing in Parkinson's disease patients with gait freezing while in the 'on' state: randomized single blind evaluation显示文摘 | Cubo E Leurgans S Goetz CG | 2004 | Parkinsonism Relat Disord2004，10，： | 1 |
| 9 | Validation of MODIS FAPAR products in boreal forests of Alaska显示文摘 | Steinberg D C Goetz S J Hyer E | 2006 | IEEE Transactions on Geoscience and Remote Sensing2006，44，7： | 1 |
| 10 | Imaging spectrometry forearth remote sensing显示文摘 | GOETZ A F VANE G SOLOMON J E | 1985 | Science1985，228，4704： | 1 |
| 11 | Organic UV filters in personal care products in Switzerland: a survey of occurrence and concentrations显示文摘 | MANOVA E VON GOETZ N HAURI U | 2012 | International Journal of Hygiene and Environmental Health2012，216，4： | 1 |
| 12 | The SV40 smallt-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do rot have this effect显示文摘 | Goetz F Tzeng YJ Guhl E etal | 2001 | Oncogene2001，20，18： | 1 |
| 13 | Social class rank, threat vigilance, and hostile reactivity 显示文摘 | KRAUS M W HORBERG E J GOETZ J L | 2011 | Personality and Social Psychol- ogy Bulletin2011，37，10： | 1 |
| 14 | Low-Loaded Pd-Pb/α- Al2O3 Catalysts: Effect of Alloying in the Hydrogenation of Buta-1,3-diene and Hydrogenation and Isomerization of Butenes显示文摘 | Goetz J Voipe M A Gigola C E | 2001 | J Catal2001，199，2： | 1 |
| 15 | Theory of Mind and Psychoses 显示文摘 | Doody G A Goetz M Johnstone E C | 1998 | Psychological Medicine1998，28，： | 1 |
| 16 | Imaging spectroscopy for earth remote sensing显示文摘 | Goetz A F H Vane G Solomon J E | 1985 | Science1985，228，： | 1 |
| 17 | Degradation and Field Persistence of Imazethapyr显示文摘 | GOETZ A J LAVY T L GBUR E E | | 0，，： | 1 |
| 18 | Intensive care after minimally invasive and conventional coronary surgery:a prospective comparison显示文摘 | Kilger E Weis FC Goetz L | 2001 | Intens Care Med2001，27，3： | 1 |
| 19 | Imaging Spectroscopy for Earth Remote Sensing显示文摘 | Goetz A F H Vane G Solomon J E | 1985 | Science1985，228，： | 1 |
| 20 | Expression and function of PPARγ in rat and human vascular smooth muscle cells显示文摘 | LAW R E GOETZE S XI X P | 2000 | Circulation2000，101，： | 1 |
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