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| 1 | Processing techniques of selected oilseed by-products of potential use in animal feed: Effects on proximate nutrient composition, amino acid profile and antinutrients显示文摘The effects of processing by autoclaving(AC), soaking(SK), short-term fermentation(S-TF, 4 d) and longterm fermentation(L-TF, 14 d) on the nutritional composition, amino acid profile and some antinutrients were determined for cottonseed meal(CSM), groundnut meal(GNM) and groundnut husk(GH) in this study. After processing, crude protein content improved by 11% after L-TF, and crude lipid content 25%after SK for CSM; crude protein content improved by 27% after S-TF and L-TF, and crude lipid content 13%after SK for GNM. Soaking and fermentation were shown to significantly increase essential amino acid contents by 44%(SK, methionine) in CSM and 46% in GNM(L-TF, histidine). Phosphorus content was reduced by 59% in CSM and 57% in GNM by L-TF. All processing techniques, with the exception of AC,reduced phytic acid and gossypol contents in CSM and GNM. It was concluded that SK and fermentation were simple, cost-effective, and efficient ways to improve the nutritional value of the selected oilseed byproducts. | Collins P.Duodu Daniel Adjei-Boateng Regina E.Edziyie Nelson W.Agbo Godfred Owusu-Boateng Bodil K.Larsen Peter V.Skov | 2018 | Animal Nutrition2018，，4： | 7 |
| 2 | 雌二醇/睾酮比值、白细胞介素6、降钙素原水平与慢性心衰的关系显示文摘目的探讨雌二醇(E2)、睾酮(T)、雌二醇/睾酮比值(E2/T)、白细胞介素6(IL-6)、降钙素原(PCT)水平变化与慢性心力衰竭(心衰)的关系。方法选取慢性心衰患者100例(心衰组)及健康体检者100例(非心衰组)为研究对象。采用酶联免疫吸附试验法(ELISA)检测血清PCT、IL-6水平,化学发光法测定检测E2、T的含量,电化学发光法检测N末端脑钠肽前体(NT-proBNP)。探讨E2/T比值、PCT、IL-6与慢性心力衰竭的关系。采用Logistic回归分析分析各组性激素、IL-6及PCT与心衰的关系并进行统计学分析。结果心衰组与非心衰组比较,E2、T、E2/T差异有统计学意义(P<0.05)。心衰组IL-6、NT-proBNP显著高于非心衰组,差异有统计学意义(P<0.05)。单因素和多因素Logistic回归分析显示:①E2/T曲线下面积(0.762,95%CI:0.690~0.835,P<0.001);②IL-6曲线下面积(0.693,95%CI:0.615~0.771,P<0.001);③NT-proBNP曲线下面积(0.792,95%CI:0.731~0.854,P<0.001)。④NT-proBNP+E2/T曲线下面积(0.823,95%CI:0.767~0.879,P<0.001)。⑤NT-proBNP+IL-6曲线下面积(0.803,95%CI:0.743~0.863,P<0.001)。结论血清E2/T比值、IL-6、NT-proBNP是心衰患者的独立危险因素。 | 陈保花 Agyekum Godfred Amfo 何婷婷 王宇 王志荣 张卓琦 孙红 | 2021 | 中国循证心血管医学杂志2021，13，12： | 5 |
| 3 | Seroprevalence of syphilis in patients attending a tertiary care hospital in Southern India显示文摘Objective:To report our experience with two tests,anti-cardiolipin antibody test[venereal disease reasearch laboratory(VDRL) test]and specific treponemal test(Treponema pallidum hemagglutination assay),used for screening antenatal,high risk cases and cases from sexually transmitted infection in a tertiary care hospital from January 2006 till December 2008.Methods:A total of 14639 samples received from various patient groups including antenatal cases,patients attending sexually transmitted disease(STD) clinic,blood donors and HIV positive patients were screened.Results:Among the 14639 samples collected,103 were positive by VDRL test.Of these 89 cases were confirmed by quantitative VDRL test and Treponema pallidum hemagglutination assay.The cumulative seroprevalence over two years was found to be 0.61%in this study.The syphilis seroprevalence reduced from 0.88%in 2006 to 0.40%in 2008.Among the various sub-populations studied,patients attending the sexually transmitted infection clinic showed a seroprevalence of 2.62%.The seroprevalence decreased significantly from 4.00%in 2006 to1.39%in 2008.Conclusions:Our study showed a statistically significant declining rate of syphilis in STD clinics as well as the overall seroprevalence.These findings could be interpreted as indicators of improved programmes for prevention and management of STDs. | Sadia Khan Godfred Antony Menezes Rahul Dhodapkar Belgode Narasimha Harish | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，12： | 2 |
| 4 | 不确定脑网络的异常拓扑分析及分类研究显示文摘静息态功能脑网络在脑疾病研究中得到了广泛的应用。然而传统的功能连接网络分析主要集中在确定图上,忽视了大脑区域之间的不确定信息。基于此,对不确定脑网络进行了研究,该方法不需要进行阈值选择,而且可以更准确地对功能连接网络进行建模。同时,将频繁子图挖掘应用到了不确定图上,并提出了几种新的判别性特征选择方法。分类结果显示,基于不确定脑网络的磁共振影像分类方法有效地提高了抑郁症诊断的准确率。 | 刘峰 Godfred Kim Mensah 李欣芸 刘鸿丽 李瑶 郭浩 | 2020 | 计算机工程与应用2020，56，2： | 2 |
| 5 | 荧光介孔二氧化硅纳米粒子的合成及药物运输(英文)显示文摘合成了荧光介孔二氧化硅纳米粒子(MSNs-FITC),并研究了其在持续药物释放和生物示踪成像方面的应用。首先,采用一步法合成出MSNs-FITC,结合SEM、TEM、FT-IR、XRD和氮气吸附脱附等表征技术进行表征。其次,将抗癌药物阿霉素(DOX)负载到MSNs-FITC中。载药粒子的药物释放行为具有明显的pH依赖性,酸性环境加速释放速率。同时,体外细胞毒性测试表明MSNs-FITC具有良好的生物相容性。激光共聚焦扫描显微镜(CLSM)图像表明,MSNs-FITC可以进入细胞并具有剂量依赖性,流式细胞术分析(FCM)进一步证明了这一结果。 | 陈敏敏 耿浩然 胡金霞 张琼 Godfred Amfo Agyekum 张卓琦 曹希传 | 2019 | 无机化学学报2019，35，11： | 2 |
| 6 | 成人暴发性心肌炎患者住院期间发生主要不良心血管事件的危险因素分析显示文摘目的分析成人暴发性心肌炎患者住院期间发生主要不良心血管事件(MACE)的危险因素。方法选取徐州医科大学附属医院于2010年5月至2020年5月诊断为暴发性心肌炎的68例患者为研究对象。收集患者基线临床资料、临床病史、心电图和超声心动图参数、实验室检查和用药情况、住院期间发生MACE事件等资料。将患者按住院期间是否发生MACE分为两组,MACE组(n=32)和非MACE组(n=36)。先通过组间单因素分析筛选可能影响预后的危险因素,然后经多因素Logistic回归分析确定影响预后的危险因素。结果成人暴发性心肌炎患者住院期间MACE发生率为47%。多因素Logistic回归分析表明,基线QRS时限>120 ms(OR=3.563,95%CI:1.139~11.144,P=0.029)、肌钙蛋白T(hsTnT)峰值(OR=2.210,95%CI:1.029~4.750,P=0.042)、左室射血分数(LVEF)(OR=0.935,95%CI:0.889~0.984,P=0.010)是院内发生MACE的危险因素。基线QRS时限>120 ms预测院内发生MACE的曲线下面积(AUC)为0.694(95%CI:0.560~0.827,P=0.006)、hsTnT峰值预测院内MACE的AUC为0.720(95%CI:0.595~0.844,P=0.002)、LVEF预测院内MACE的AUC为0.736(95%CI:0.611~0.861,P=0.001)。结论暴发性心肌炎患者临床预后差,基线QRS时限、hsTnT峰值、左室射血分数(LVEF)是暴发性心肌炎患者住院期间发生主要不良心血管事件的危险因素。 | 陈保花 AGYEKUM Godfred Amfo 何婷婷 王宇 王志荣 张卓琦 | 2021 | 中国循证心血管医学杂志2021，13，7： | 2 |
| 7 | Anti-onchocerca Metabolites from Cyperus articulatus:Isolation,In Vitro Activity and In Silico‘Drug-Likeness’显示文摘The aims of this investigation were to isolate active ingredients from the roots/rhizomes of Cyperus articulatus used as herbal medicine in Cameroon for the treatment of human onchocerciasis and to assess the efficacy of the metabolites on the Onchocerca worm.The antifilarial activity was evaluated in vitro on microfilariae(Mfs)and adult worms of the bovine derived Onchocerca ochengi,a close relative of Onchocerca volvulus.Cytotoxicity was assessed in vitro on monkey kidney epithelial cells.The structures of the active compounds were determined using spectroscopic methods and their drug-likeness evaluated using Lipinski parameters.Two secondary metabolites,AMJ1[containing mustakone(1)as the major component]and linoleic acid or(9Z,12Z)-octadeca-9,12-dienoic acid(2)were isolated.Both compounds were found to kill both the microfilariae and adult worms of O.ochengi in a dose dependent manner.The IC50s for AMJ1 were 15.7 lg/mL for Mfs,17.4 lg/mL for adult males and 21.9 lg/mL for adult female worms while for linoleic acid the values were,15.7 lg/mL for Mfs,31.0 lg/mL for adult males and 44.2 lg/mL for adult females.The present report provides the first ever evidence of the anti-Onchocerca efficacy of AMJ1 and linoleic acid.Thus,these secondary metabolites may provide a lead for design and development of new antifilarial agents. | Jonathan Alunge Metuge Smith B.Babiaka James A.Mbah Fidele Ntie-Kang Godfred A.Ayimele Fidelis Cho-Ngwa | 2014 | Natural Products and Bioprospecting2014，4，4： | 2 |
| 8 | HDAC6 inhibition regulates substrate stiffness-mediated inflammation signaling in chondrocytes显示文摘Osteoarthritis(OA)is a chronic disease and is difficult to cure.Chondrocytes are highly mechanosensitive.Therefore,mechanical therapies have received attention as a therapeutic direction for OA.The stiffness,as a critical cue of the extracellular matrix(ECM),affects cell growth,development,and death.In this study,we use polydimethylsiloxane(PDMS)to create substrates with varying stiffness for chondrocyte growth,interleukin-1β(IL-1β)treatment to mimic the inflammatory environment,and Tubastatin A(Tub A)to inhibit histone deacetylase 6(HDAC6).Our results show that stiff substrates can be anti-inflammatory and provide a better matrix environment than soft substrates.Inhibition of HDAC6 improves the inflammatory environment caused by IL-1βand coordinates with inflammation to spread the chondrocyte area and primary cilia elongation.Without IL-1βand Tub A treatments,the length of the primary cilia rather than frequency is stiffness-dependent,and their length on stiff substrates are greater than that on soft substrates.In conclusion,we demonstrate that stiff substrates,inflammation,and inhibition of HDAC6 enhance the mechanosensitivity of primary cilia and mediate substrate stiffness to suppress inflammation and protect the matrix. | Yang Zhang Godfred K Tawiah Yanjun Zhang Xiaohu Wang Xiaochun Wei Weiyi Chen Xiaohong Qiao Quanyou Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 1 |
| 9 | Does aspirin use make it harder to collect seizures during elective video-EEG telemetry?显示文摘 | Rachel M. Godfred Mihir S. Parikh Alan M. Haltiner Lisa M. Caylor Jehuda P. Sepkuty Michael J. Doherty | 2013 | Epilepsy & Behavior2013，，1： | 1 |
| 10 | The lubrication mechanism of tricresyl phosphateon steel显示文摘 | GODFRED D | 1965 | ASLE Transaction1965，8，1： | 1 |
| 11 | A randomized trial of video self-instruction in cardiopulmonary resuscitation for lay persons 显示文摘 | Godfred R Huszti E Fly D | 2013 | Scandinavian Journal of Trauma Resuscitation and Emergency Medicine2013，10，21： | 1 |
| 12 | Persistent organochlorine pesticide residues in fish,sediments and water from Lake Bosomtwi,Ghana显示文摘 | Godfred Darko Osei Akoto Caleb Oppong | 2008 | Chemosphere2008，72，： | 1 |
| 13 | Small size at birth and greater postnatal weight gain:relationships to diminished infant lung function显示文摘 | Lucas JS Inskip HM Godfred KM | 2004 | Am J Resp Crit Care2004，170，： | 1 |
| 14 | Does aspirin use make it harder to collect seizures during elective video-EEG telemetry? 显示文摘 | Godfred RM Parikh MS Haltiner AM | 2013 | Epilepsy Behav2013，27，1： | 1 |
| 15 | Microenterprise financ- ing preference:Testing POH within the context of Ghana's rural financial market 显示文摘 | Eric 0 A Godfred A B Daniel K T | 2012 | Journal of Economic Studies2012，39，1： | 1 |
| 16 | Electrospun nanofibers as sorbent material for solid phase extraction显示文摘 | Samuel Chigome Godfred Darko Nelson Torto | 2011 | Analyst2011，136，： | 1 |
| 17 | Using origin analysis to detect mergingand splitting of source code entities显示文摘 | GODFRE M W ZOU Li-jie | 2005 | IEEE Trans on SoftwareEngineering2005，31，2： | 1 |
| 18 | Exposures and risks of arsenic,cadmium,lead,and mercury in cocoa beans and cocoa-based foods:a systematic review显示文摘Background:The World Health Organization has expressed concern about arsenic,cadmium,lead,and mercury as potentially harmful to human health.As such,the world body has called for appropriate preventive and interventionary measures.In response,food regulatory bodies including European Food Safety Authority are monitoring the levels of these heavy metals in cocoa and cocoa products.Objective:Therefore,the objective of this paper is to synthesize the latest relevant available peer-reviewed publications on arsenic,cadmium,lead,and mercury with a view to highlighting the gaps to encourage further research and informing industry.Materials and Methods:A systematic review was conducted using the European Food Safety Authority guide in PubMed database and the result was reported according to the PRISMA checklist.Results:The results show that processing may dilute or concentrate the levels of arsenic,cadmium,lead,and mercury,depending on processing factors including the product type,processing method,and raw materials.In addition,some products exceed the European Union and Chinese Maximum Contaminant Level and may pose risk.Furthermore,the findings show that the risk of heavy metal toxicities was higher among children relative to adults at the same exposure in cocoa-based products and that correcting risk estimates for bioavailability reduces the level of estimated risk.Conclusion:Therefore,the review concludes that further research is required to clarify the effect of processing on the level of these contaminants in specific cocoa-based foods.Moreover,conducting risk studies based on age groups and correcting for bioavailability of arsenic,cadmium,lead,and mercury enhance accuracy of risk estimates.Recommendations:The review,therefore,recommends that a value chain approach be adopted to assessing the levels,exposures,and risks of arsenic,cadmium,lead,and mercury in cocoa-based foods and the effect of processing on these levels. | Ekpor Anyimah-Ackah Isaac W.Ofosu Herman E.Lutterodt Godfred Darko | 2019 | Food Quality and Safety2019，3，1： | 1 |
| 19 | Genetic control of the rate of wound healing in mice显示文摘 | X Li Weikuan GU and Godfred M | 2001 | Heredity2001，86，6： | 1 |
| 20 | Isolation of wound healing/regeneration genes using restrictive fragment differential display-PCR in MRL/MPJ and C57BL/6 mice显示文摘 | Godfred M Xinmin L David J | 2005 | Biochemical and Biophysical Research Communications2005，330，1： | 1 |
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