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| 1 | Long-term results of endoscopic balloon dilatation of lower gastrointestinal tract strictures in Crohn's disease:A prospective study显示文摘AIM:To examine the long-term results of endoscopic treatment in a prospective study conducted over a period of 10 years,1997 to January 2007.METHODS:A total of 25 patients(20 female and five male:aged 18-75 years),with at least one symptom of stricture not passable with the standard colonoscope and with a confirmed scarred Crohn's stricture of the lower gastrointestinal tract,were included in the study.The main symptom was abdominal pain.The endoscopic balloon dilatation was performed with an 18 mm balloon under endoscopic and radiological control.RESULTS:Eleven strictures were located in the colon,13 at the anastomosis after ileocecal resection,three at the Bauhin valve and four in the ileum.Four patients had two strictures and one patient had three strictures.Of the 31 strictures,in 30 was balloon dilatation successful in a single endoscopic session,so that eventually the strictures could be passed easily with the standard colonoscope.In one patient with a long stricture of the ileum involving the Bauhin valve and an additional stricture of the ileum which were 15 cm apart,sufficient dilatation was not possible.This patient therefore required surgery.Improvement of abdominal symptoms was achieved in all cases which had technically successful balloon dilatation,althoughin one case perforation occurred after dilatation of a recurrent stricture.Available follow-up was in the range of 54-118 mo(mean of 81 mo).The relapse rate over this period was 46%,but 64% of relapsing strictures could be successfully dilated again.Only in four patients was surgery required during this follow-up period.CONCLUSION:We conclude from these initial results that endoscopic balloon dilatation,especially for short strictures in Crohn's disease,can be performed with reliable success.Perforation is a rare complication.It is our opinion that in the long-term,the relapse rate is probably higher than after surgery,but usually a second endoscopic treatment can be performed successfully,leading to a considerable success rate of the endoscopic procedure. | Klaus Stienecker Daniel Gleichmann Ulrike Neumayer H Joachim Glaser Carolin Tonus | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 2 | Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks显示文摘 | Gleichmann M Zhang Y Wood W H | 2012 | Neurobiol Aging2012，33，1： | 1 |
| 3 | Percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy:results with respect to intraprocedural myocardial contrast echocardiography显示文摘 | Faber L Seggewiss H Gleichmann U | | 0，，22： | 1 |
| 4 | Nickel allergy in mice:enhanced sensitization capacity of nickel at higher oxidation states显示文摘 | Artik S von VultééC Gleichmann E | 1999 | J Immunol1999，163，： | 1 |
| 5 | Percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy:acute redulyd snf 3-month follow-up in 25 patients显示文摘 | Gleichmann U Faber L | 1998 | JACC1998，31，： | 1 |
| 6 | Mitochondria in neuroplasticity and neurological disorders显示文摘 | Mattson MP Gleichmann M Cheng A | | 0，，05： | 1 |
| 7 | Cloning and characterization of SDF-1 gamma,a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system显示文摘 | Gleichmann M Gillen C Czardybon M | 2000 | Eur J Neuro sci2000，12，6： | 1 |
| 8 | Glut2 in pancreatic islets crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice显示文摘 | Wang Z Y Gleichmann H | 1998 | Diabetes1998，47，： | 1 |
| 9 | Bilateral optic disk edema in polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins and skin changes ( POEMS syndrome ) 显示文摘 | Barry JC Gleichmann M Wilhelm H | 1999 | Klin Monatsbl Augenheilkd1999，215，1： | 1 |
| 10 | Percutaneous transluminal septal ablation in hypertrophic obstructive cardiomypathy显示文摘 | Seggewiss H Faber L Gleichmann U | 1999 | Thorac Cardiovasc Surg1999，47，： | 1 |
| 11 | Percutaneous transluminal septal myocardial ablation in obstructive hypertrophic cardiomyopathy:acute results and 3-month follow-up in 25 patients显示文摘 | SEGGEWISS H GLEICHMANN U FABER L | 1998 | J Am Coll Cardiol1998，31，： | 1 |
| 12 | GLUT2 in pancreatic islets:crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice显示文摘 | Wang Z Gleichmann H | | 0，，01： | 1 |
| 13 | Percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy:acute and 3-month s follow-up results with respect to myocardial contrast echocardiography显示文摘 | Faber L Seggewiss H Gleichmann U | 1998 | C ircculation1998，98，： | 1 |
| 14 | Cloning and characterization of SDF- 1 gamma, a novel SDF- 1 chemokine transcript with developmentally regulated expression in the nervous system显示文摘 | Gleichmann M Gillen C Czardybon M | 2000 | Eur J Neuro Sci2000，12，6： | 1 |
| 15 | Percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy: acute results and 3-month follow-up in 25 patients显示文摘 | Seggewiss H Gleichmann U Faber L | 1998 | J Am Coll Cardiol1998，31，2： | 1 |
| 16 | Percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy:Results with respect to intraprocedural myocardial contrast echocardiography显示文摘 | Faber L Seggewiss H Gleichmann U | 1998 | Circulation1998，98，22： | 1 |
| 17 | Percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy : results with respect to intraprocedural myocardial contrast echocardiography 显示文摘 | Faber L Seggewiss H Gleichmann U | 1998 | Circulation1998，98，22： | 1 |
| 18 | Percutaneous transluminal septal myocardial ablation in hypertrophic obstructive caudiomyopathy:acute results and 3- month follow-up in 25 patients显示文摘 | Seggewiss H Gleichmann U Faber L | 1998 | J Am Coll Cardiol1998，31，2： | 1 |
| 19 | Insulin-like growth factor-1-mediated protection from neuronal apoptosis is linked to phosphorytation of the pro-apoptotic protein BAD but not to inhibition of cytochromec translocation in rat cerebellar neurons显示文摘 | Gleichmann M Weller M Schulz J B | 2000 | Neurosci Lett2000，282，12： | 1 |
| 20 | Percutaneous transluminal septal ablation in hypertropic obstructive cardiomyopathy显示文摘 | Seggewiss H Faber L Gleichmann U | 1999 | Thomc Cardiovasc Surg1999，47，： | 1 |
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