|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A phase II trial of nab -paelitaxel as second -line therapy in patients with advansed pancreatic cancer 显示文摘 | Hosein Peter J Gilberto Jr Pastorini et at | 2013 | Am J Clin Oneol2013，36，2： | 1 |
| 2 | Symptomatic hypoglycemia related to inappropriately high IGF-II serum levels in a patient with desmoplastic small round cell tumor显示文摘 | Williams FB Gilberto Castro Jr Ana Oliveira Hoff | 2010 | Case Repo Med2010，2010，68： | 1 |
| 3 | A novel fluorinated Eu (III)β-diketone complex as thin film for optical device applications 显示文摘 | Gilberto F de Sa Severino Alves Jr | 1998 | Optical Materials1998，11，1： | 1 |
| 4 | Biocompatibility studies of anionic collagen membranes with different degree of glutaraldehyde cross-linking显示文摘 | Gilberto G Marcanoio E Jr Lia RC | 1999 | Biomaterials1999，20，1： | 1 |
| 5 | Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats显示文摘AIM:To investigate hepcidin expression,interleukin-6(IL-6)production and iron levels in the rat colon in the presence of trinitrobenzene sulfonic acid(TNBS)-induced colitis.METHODS:In rats,we evaluated the severity of colitis induced by repeated TNBS administration using macroscopic and microscopic scoring systems and myeloperoxidase activity measurements.The colonic levels of hepcidin,tumor necrosis factor alpha(TNF-α),IL-10 and IL-6 were measured by Enzyme-Linked Immunosorbent Assay,and hepcidin-25 expression and iron deposition were analyzed by immunohistochemistry and the Prussian blue reaction,respectively.Stat-3 phosphorylation was assessed by Western blot analysis.Hematological parameters,iron and transferrin levels,and transferrin saturation were also measured.Additionally,the ability of iron,pathogen-derived molecules and IL-6 to induce hepcidin expression in HT-29 cells was evaluated.RESULTS:Repeated TNBS administration to rats resulted in macroscopically and microscopically detectable colon lesions and elevated colonic myeloperoxidase activity.Hepcidin-25 protein levels were increased in colonic surface epithelia in colitic rats(10.2±4.0pg/mg protein vs 71.0±8.4 pg/mg protein,P<0.01).Elevated IL-6 levels(8.2±1.7 pg/mg protein vs 14.7±0.7 pg/mg protein,P<0.05),TNF-αlevels(1.8±1.2pg/mg protein vs 7.4±2.1 pg/mg protein,P<0.05)and Stat-3 phosphorylation were also observed.Systemic alterations in iron homeostasis,hepcidin levels and anemia were not detected in colitic rats.Iron deposition in the colon was only observed during colitis.Hepcidin gene expression was increased in HT-29 cells after IL-6 and lipopolysaccharide[a toll-like receptor 4(TLR-4)ligand]treatment.Deferoxamine,ferric citrate and peptidoglycan(a TLR-2 ligand)were unable to alter the in vitro expression of hepcidin in HT-29 cells.CONCLUSION:Colitis increased local hepcidin-25 expression,which was associated with the IL-6/Stat-3 signaling pathway.An increase in local iron sequestration was also observed,but additional studies are needed to determine whether this sequestration is a defensive or pathological response to intestinal inflammation. | Erica Martins Ferreira Gotardo Gilberto de Almeida Ribeiro Thayane Rodrigues Leite Clemente Camila Henrique Moscato Renata Bortolin Guerra Tome Thalita Rocha Jose Pedrazzoli Jr Marcelo Lima Ribeiro Alessandra Gambero | 2014 | World Journal of Gastroenterology2014，20，15： | 1 |
| 6 | Modified FLOX as first-line chemotherapy for metastatic colorectal cancerpatients in the public health system in Brazil: Effectiveness and cost-utilityanalysis显示文摘 | Daniela Nebuloni Milena Mak Fabiano Souza Daniel Saragiotto Thiago Júlio Gilberto De Castro Jr Jorge Sabbaga Paulo Hoff | 2013 | Molecular and Clinical Oncology2013，，： | 1 |
| 7 | Mechanical properties and connectivity evaluation of a conductive coated piezoceramic/polymer composite显示文摘In the present work,piezoelectric composite films made of Polyaniline(PAni)coated Lead Zirconate Titanate(PZT)particles immersed into polyvinylidene fluoride(PVDF)matrix were characterized by mechanical tests,and the connectivity of the com-posite sample was determined using dielectric measurements and applying the Poon–Shin model.The composite was considered a binary system with coated PZT particles as one phase and the polymer matrix the other one.To support the result obtained from theoretical analysis,scanning electron microscopy of the composites were done.It was observed a decrease up to 85%on the mechanical resistance when the ceramic volume fraction increases from 0%to 40%.Furthermore,the composite film no longer can be considered with 0–3 connectivity when the ceramic content is 30 vol.%or over. | Gilberto de Campos Fuzari Jr Walter Katsumi Sakamoto | 2014 | Journal of Advanced Dielectrics2014，4，3： | 0 |
| 8 | Acute-on-chronic liver failure is independently associated with higher mortality for cirrhotic patients with acute esophageal variceal hemorrhage:Retrospective cohort study显示文摘BACKGROUND Acute esophageal variceal hemorrhage(AEVH)is a common complication of cirrhosis and might precipitate multi-organ failure,causing acute-on-chronic liver failure(ACLF).AIM To analyze if the presence and grading of ACLF as defined by European Society for the Study of the Liver-Chronic Liver Failure(EASL-CLIF)is able to predict mortality in cirrhotic patients presenting AEVH.METHODS Retrospective cohort study executed in Hospital Geral de Caxias do Sul.Data from medical records from 2010 to 2016 were obtained by searching the hospital electronic database for patients who received terlipressin.Medical records were reviewed in order to determine the diagnosis of cirrhosis and AEVH,including 97 patients.Kaplan-Meier survival analysis was used for univariate analysis and a stepwise approach to the Cox regression for multivariate analysis.RESULTS All-cause mortality for AEVH patients was 36%,40.2%and 49.4%for 30-,90-and 365-day,respectively.The prevalence of ACLF was 41.3%.Of these,35%grade 1,50%grade 2 and 15%grade 3.In multivariate analysis,the non-use of non-selective beta-blockers,presence and higher grading of ACLF and higher Model for End-Stage Liver Disease scores were independently associated with higher mortality for 30-day with the addition of higher Child-Pugh scores for 90-day period.CONCLUSION Presence and grading of ACLF according to the EASL-CLIF criteria was independently associated with higher 30-and 90-day mortality in cirrhotic patients admitted due to AEVH. | Alana Zulian Terres Rafael Sartori Balbinot Ana Laura Facco Muscope Morgana Luisa Longen Bruna Schena Bruna Teston Cini Gilberto Luis Rost Jr Juline Isabel Leichtweis Balensiefer Louise Zanotto Eberhardt Raul Angelo Balbinot Silvana Sartori Balbinot Jonathan Soldera | 2023 | World Journal of Clinical Cases2023，11，17： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员