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| 1 | 根治性手术与短程放疗后行经肛门内镜显微手术(TEM)保留器官治疗早期直肠癌(TREC):一项随机、开放标签的可行性研究显示文摘背景:基于全直肠系膜切除(total mesorectal excision,TME)的根治性手术可能不是早期直肠癌的最佳一线治疗。选择性TME保留器官的策略可以减少治疗的不良反应,又不会显著影响肿瘤结果。该临床随机研究通过与TME比较,探讨器官保留策略的可行性。方法:TREC是一项在英国21个三级转诊中心进行的随机、开放标签的可行性研究。符合条件的受试者年龄≥18岁,分期为T2期或更早,最大直径不超过30 mm;排除淋巴结受累或转移的患者。患者按计算机随机分配(1:1)接受短程放疗保留器官,8~10周后行经肛门内镜显微手术(transanal endo⁃scopic microsurgery,TEM)或TME术。当TEM标本组织病理学特征提示局部复发风险增加时,患者被考虑计划早期转为TME。一项非随机前瞻性登记收集了认为不适合随机化的患者,因为每例患者都是按临床指征治疗的。主要终点为12、18和24个月的累积随机分组。次要结局为应用欧洲癌症研究与治疗组织(EORTC)QLQ C30和CR29量表对意向治疗人群的安全性、有效性和健康相关生活质量进行了评价。该研究已在ISRCTN注册中心注册,ISRCTN14422743。 | 佟伟华 BACH S P GILBERT A BROCK K | 2021 | 结直肠肛门外科2021，27，3： | 9 |
| 2 | Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality显示文摘 | Peter K Henke Susan Blackburn Mary C Proctor Jeri Stevens Debabrata Mukherjee Sanjay Rajagopalin Gilbert R Upchurch James C Stanley Kim A Eagle | 2004 | Journal of Vascular Surgery2004，，： | 2 |
| 3 | Quantitation of transplanted hepatic mass necessary to cure the Gunn rat model of hyperbilirubinemia显示文摘 | Asonuma K Gilbert JC Stein JE | 1992 | J Pediatr Surg1992，27，3： | 1 |
| 4 | Peptide absorption anti utiliza- tion: Implications for animal nutrition and health显示文摘 | Gilbert E R Wong E Webb K E | 2008 | Jourual of Animal Science2008，86，： | 1 |
| 5 | Passenger expectations and airline services: a Hong Kong based study 显示文摘 | GILBERT D WONG R K | 2003 | Tourism Management2003，24，5： | 1 |
| 6 | Repeated horizontal transfer of a DNA transposon in mammals and other tetrapods 显示文摘 | Pace J K 2nd Gilbert C Clark M S | 2008 | Proc Natl Acad Sci USA2008，105，17： | 1 |
| 7 | 5-Lipoxygenase is a direct p53 target gene in humans显示文摘 | Gilbert B Ahmad K Roos J er a! | 2015 | Biochim Biophys Acta2015，1849，8： | 1 |
| 8 | Performance of full cells containing carbonate-based Li FSI electrolytes and silicon-graphite negative electrodes显示文摘 | TRASK S E PUPEK K Z GILBERT J A | 2016 | Journal of the Electrochemical Society2016，163，3： | 1 |
| 9 | Increase in crystallinity in poly(vinylidene fluoride) by electron beam radiatipon显示文摘 | PAE K D BHATEJA K K GILBERT J R | 1987 | Polym Sci Phys Ed1987，25，8： | 1 |
| 10 | Stormwater runoff quality and quantity from asphalt,paver,and crushed stone driveways in Connecticut显示文摘 | Gilbert J K Clausen J C | 2006 | Water Res2006，40，4： | 1 |
| 11 | Pharmacodynamics of ziprasidone in children and adolescents: impact on dopamine transmission 显示文摘 | Sallee FR Gilbert DL Vinks AA Miceli JJ Robarge L Wilner K | 2003 | J Am Acad Child Adolesc Psychiatry2003，42，8： | 1 |
| 12 | CD4 ( +)T-cell ac-tivation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL + 1+ mice显示文摘 | Griffin J M Gilbert K M Lamps L W | 2000 | Toxicol Sci2000，57，2： | 1 |
| 13 | Boardinvited review: peptide absorption and utilization: implications for animal nutrition and health 显示文摘 | GILBERT E R WONG E A WEBB K E Jr | 2008 | Journal of Animal Science2008，86，9： | 1 |
| 14 | Pathology teach and tell: eosinophilic granuloma 显示文摘 | Khalil F K Wallis Crespo M C Gilbert Barness E | 2004 | Fetal Pediatr Pathol2004，23，4： | 1 |
| 15 | Standards for nutrition support: adult hospitalized patients nutrition in clinical practice 显示文摘 | Ukleja A Freeman KL Gilbert K | 2010 | Nutr Clin Pract August2010，25，4： | 1 |
| 16 | Suspended clay and the population dynamics of planktonic rotifers and cladocerans显示文摘 | KIRK K L GILBERT J J | 1990 | Ecology1990，71，： | 1 |
| 17 | Slope reliability analysis using generalized method of slices显示文摘 | LOW B K GILBERT R B WRIGHT S G | 1998 | Journal of Geotechnical and Geoenvironmental Engineering1998，124，4： | 1 |
| 18 | Solid-state mater 显示文摘 | Singh R K Gilbert D R Viatella J | 1996 | Hdvanced Techno1996，8，1： | 1 |
| 19 | Slope Reliability analysis using generalized method of slices 显示文摘 | LOW B K GILBERT R B WRIGHT S G | 1998 | Journal of Geotechnieal and Geoenvironmental Engineering1998，124，5： | 1 |
| 20 | The expression and gene structure of a G protein-coupled glutamate receptor显示文摘 | Houamed K W Kuijper J L Gilbert T L | 1991 | Science1991，31，252： | 1 |
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