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	题名	作者	年代	出处	被引量
1	Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW.	John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou	2005	World Journal of Gastroenterology2005，11，43：	5
2	Effects of chromium on activated sludge and on the performance of wastewater treatment plants: A review显示文摘	Eleni Vaiopoulou Petros Gikas	2011	Water Research2011，，3：	3
3	Current strategies for knee carti- lage repair显示文摘	Kalson NS Gikas PD Briggs TW	2010	Int J Clin Pract2010，64，10：	1
4	Local recurrence of osteosarcoma after 17 years显示文摘	Welck MJ Gikas PD Pearce P		0，，：	1
5	Surgical treatment of spinal brucellosis显示文摘	Katonis P Tzermiadianos M Gikas A	2006	Clin Orthop Relat Res2006，444，：	1
6	The present state of treat ments for articular cartilage defects in the knee显示文摘	Perera JR Gikas PD Bentley G	2012	Ann R Coll Surg Engl2012，94，6：	1
7	Investigation of chro- nic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass speclrometry based metabolite profiling 显示文摘	Gika HG Ji C Theodoridis GA ct al	2012	J ChromatogrA2012，1259，：	1
8	Management of gynaecomastia: an update 显示文摘	Gikas P Mokbel K	2007	Int J Clin Pratt2007，61，7：	1
9	LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics显示文摘	Theodoridis G Gika H G Wilson I D	2008	Trac-trend Anal Chem2008，27，3：	1
10	Prechemotherapy serum levels ofCDios, transforming growth factor beta2, and vascular endothelialgrowth factor are associated with prognosis io patients with ad-vanced epithelial ovarian cancer treated with cytoreductive surgeryand platinum-based chemotherapy 显示文摘	Bozas G Terpos E Gika D	2010	Int J Gynecol Cancer2010，20，2：	1
11	Three-dimensional laser scanning for geometry documentation and construction management of highway tunnels during excavation显示文摘	Gikas V	2012	Sensors2012，12，11：	1
12	Liquid chromatography - mass spectrometry based global metabolite profiling : a review 显示文摘	Theodoridis GA Gika HG Want E J	2012	Anal Chim Acta2012，711，20：	1
13	Modeling of non-point source pollution in a Mediter rane and raina~e basin 显示文摘	GIKAS G D YIANNAKOPOULOU T TSIHRINTZIS V A	2006	Environmental Modeling and Assessment2006，11，3：	1
14	Bcl-2 overexpression enhances in vitro sensitivity against docetaxel in non-small cell lung cancer显示文摘	Inoue Y Gika M Abiko T	2005	Oncol Rep2005，13，2：	1
15	Brain metastases as isolated site of relapse in patients with epithelial ovarian cancer previously treated with platinum and paclitaxel-based chemotherapy显示文摘	Kastritis E Efstathiou E Gika D	2006	Int J Gynecol Cancer2006，16，：	1
16	Simultaneous determination of terbuthylazine and its major hydroxy and dealkylated metabolites in wetland water samples using solid-phase extraction and high-performance liquid chromatography with diode-array detection 显示文摘	Papadopoulos N Gikas E Zalidis G	2007	Journal of Agricultural and Food Chemistry2007，55，18：	1
17	Clinical outcomes of extra-thoracic solitary fibrous tumours 显示文摘	Cranshaw IM Gikas PD Fisher C	2009	Eur J Surg Oncol2009，35，9：	1
18	Peak purity determination with a diode array detector 显示文摘	Papadoyannis I N Gika H	2005	Journal of liquid chro- matography & related technologies2005，27，6：	1
19	Osteonecrosis of the jaw in cancer after treatment with bisphosphonates:incidence and risk factors显示文摘	Bamias A Kastritis E Bamia C Moulopoulos LA Melakopoulos I Bozas G Koutsoukou V Gika D Anagnostopoulos A Papadimi-triou C Terpos E Dimopoulos MA		0，，：	1
20	Management of gynaecomastia:an update显示文摘	Gikas P Mokbel K		0，，07：	1

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