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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | In vitro and in vivo genotoxicity assessment of Ct(VI) using comet assay in earthworm coelornocytes显示文摘 | Manerikar RS Apte AA Ghole VS | 2008 | Environmental Toxicology and Pharmacology2008，25，1： | 1 |
| 3 | Plasmid-borne extended-spectrum-lactamase in a clinical isolate of Acinetobacter baumannii显示文摘 | Joshi SG Litake G Ghole VS | 2003 | J Med Microbiol2003，52，12： | 1 |
| 4 | Plasmid borne extendedspectrum beta-lactamase in a clinical isolate of Acinetobacter baumannii显示文摘 | Joshi SG Liake G Ghole VS etal | 2003 | J Med Microbiol2003，52，12： | 1 |
| 5 | Rapid method for the preparation of an AGE-BSA standard calibrator using thermal glycation 显示文摘 | Bhatwadekar AD Ghole VS | 2005 | J Clin Lab Anal2005，19，1： | 1 |
| 6 | Incremental and single trauma produce equivalent subfailu soft tissue injury of the cervical spine 显示文摘 | Ghole SA Ivancic PC Tominaga Y | 2004 | Clin Biomech2004，19，： | 1 |
| 7 | Plasmid-borne extended-spectrum beta-lactamase in a clinical isolate of Acinetobacter baumannii显示文摘 | Joshi SG Litake GM Ghole VS | | 0，，12： | 1 |
| 8 | Validation of an in situ solidification/stabilization technique for hazardous barium and cyanide waste for safe disposal into a secured landfill显示文摘 | Vaidya R Kodam K Ghole V Surya M R | | 0，，09： | 1 |
| 9 | A new approach in wetland systems for domestic wastewater treatment using Phragmites sp显示文摘 | Valipour A Kalyan Raman V Ghole V.S | | 0，，12： | 1 |
| 10 | Plasmidborne extended-spectrum-lactamase in a clinical isolate of Acinetobacter baumannii显示文摘 | JOSHI S G LIAKE G GHOLE V S | 2003 | J Med Microbiol2003，52，12： | 1 |
| 11 | Plasmid borne extended spectrum β lactamase in a clinical isolate of Acinetobacter baumannii 显示文摘 | Joshi SG Litake GM Ghole VS | 2003 | Med Microbiol2003，52，： | 1 |
| 12 | Rapid method for the preparation of an AGE-BSA standard calibrator using thermal glycation显示文摘 | BHATWADEKAR A D GHOLE V S | 2005 | Clin Lab Anal2005，19，1： | 1 |
| 13 | Glutathione and cinnamic acid: natural dietary components used in preventing the process of browning by inhibition of Polyphenol Oxidase in apple juice显示文摘 | GACCHE R N WARANGKAR S C GHOLE V S | 2004 | Journal of Enzyme Inhibition and Medicinal Chemistry2004，19，： | 1 |
| 14 | Effect of Diabecon on sugar-induced lens opacity in organ culture: mechanism of action显示文摘 | M.S. Moghaddam P. Anil Kumar G. Bhanuprakash Reddy V.S. Ghole | 2004 | Journal of Ethnopharmacology2004，，2： | 1 |
| 15 | Plasmid-borne extendedspectrum-β-lactamase in a clinical isolate of Acinetobacter baumannii显示文摘 | Joshi SG Litake GM Ghole VS | 2003 | J Med Microbiol2003，52，： | 1 |
| 16 | Presacral extramedullary hem- atopoiesis : report of a case and review of the literature 显示文摘 | Gupta P Eshaghi N Ghole V | 2008 | Clin Imaging2008，32，6： | 1 |
| 17 | Rapid method for the preparation of an AGE-BSA standard calibrator using thermal glyeation 显示文摘 | BHATWADEKAR A D GHOLE V S | 2005 | Clin Lab Anal2005，19，1： | 1 |
| 18 | Presacral extramedullary hematopoiesis : report of a case and re-view of the Iiterature显示文摘 | Gupta P Eshaghi N Ghole V Ketkar M Garcia-Morales F | 2008 | Clin Imaging2008，32，： | 1 |
| 19 | Intestinal ischemia reperfusion injury in transgenic mice overexpressing copper- zinc superoxide dismutase 显示文摘 | Deshmukh DR Mirochnitchenko O Ghole VS | 1997 | Am J Physiol1997，273，4： | 1 |
| 20 | Rapid method for the p reparation of an AGE-BSA standard calibrator using thermal glycation显示文摘 | BHATWADEKAR A D GHOLE V S | 2005 | Clin Lab Anal2005，19，1： | 1 |
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