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103篇 您的检索式：作者名="Ghaneh"

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	题名	作者	年代	出处	被引量
1	Management of necrotizing pancreatitis显示文摘Infection complicating pancreatic necrosis leads to persisting sepsis, multiple organ dysfunction syndrome and accounts for about half the deaths that occur following acute pancreatitis. Severe cases due to gallstones require urgent endoscopic sphincterotomy. Patients with pancreatic necrosis should be followed with serial contrast enhanced computed tomography (CE-CT) and if infection is suspected fine needle aspiration of the necrotic area for bacteriology (FNAB) should be undertaken. Treatment of sterile necrosis should initially be non-operative. In the presence of infection necrosectomy is indicated. Although traditionally this has been by open surgery, minimally invasive procedures are a promising new alternative. There are many unresolved issues in the management of pancreatic necrosis. These include, the use of antibiotic prophylaxis, the precise indications for and frequency of repeat CE-CT and FNAB,and the role of enteral feeding.	John Slavin Paula Ghaneh Robert Sutton Mark Hartley Peter Rowlands Conall Garvey Mark Hughes John Neoptolemos	2001	World Journal of Gastroenterology2001，7，4：	21
2	Adjuvant therapy in pancreatic cancer显示文摘Pancreatic cancer remains one of the leading causesof cancer related death worldwide with an overall fiveyear survival of less than 5%.Potentially curative surgery,which alone can improve 5-year survival to 10%,is an option for only 10%-20%of patients at presentation owing to local invasion of the tumour or metastaticdisease.Adjuvant chemotherapy has been shown toimprove 5-year survival to 20%-25%but conflicting evidence remains with regards to chemoradiation.In thisarticle we review the current evidence available frompublished randomised trials and discuss ongoing phaseⅢtrials in relation to adjuvant therapy in pancreaticcancer.	Owain Peris Jones James Daniel Melling Paula Ghaneh	2014	World Journal of Gastroenterology2014，20，40：	5
3	Adjuvant therapy in pancreatic cancer显示文摘The outlook for patients with pancreatic cancer has been grim. There have been major advances in the surgical treatment of pancreatic csncer, leading to a drsmatic reduction in post-operative mortality from the development of high volume specialized centres. This stimulated the study of adjuvant and neoadjuvant treatments in pancreatic cancer including chemoradiotherapy and chemotherapy. Initial protocols have been based on the original but rather small GITSG study first reported in 1985. There have been two large European trials totalling over 600 patients (EORTC and ESPAC-1) that do not support the use of chemoradiation as adjuvant therapy. A second major finding from the ESPAC-1 trial (541 patients randomized) was some but not conclusive evidence for a survival benefit associated with chemotherapy. A third major finding from the ESPAC-1 trial was that the quality of life was not affected by the use of adjuvant treatments compared to surgery alone.The ESPAC-3 trial aims to assess the definitive use of adjuvant chemotherapy in a randomized controlled trial of 990 patients.	Paula Ghaneh John Slavin Robert Sutton Mark Hartley John P Neoptolemos	2001	World Journal of Gastroenterology2001，7，4：	3
4	Early and late complications after pancreatic necrosectomy显示文摘	S. Connor N. Alexakis M.G.T. Raraty P. Ghaneh J. Evans M. Hughes C.J. Garvey R. Sutton J.P. Neoptolemos	2005	Surgery2005，，5：	2
5	Adenovirus mediated transfcr of p53 and p16 (INK4a) results in pancreatic cancer regression in vitro and in vivio 显示文摘	GHANEH P GREENHALF W HUMPHREYS M	2001	Gene Ther2001，8，3：	2
6	Minimal Access Retroperitoneal Pancreatic Necrosectomy: Improvement in Morbidity and Mortality With a Less Invasive Approach显示文摘	Michael G. T. Raraty Christopher M. Halloran Susanna Dodd Paula Ghaneh Saxon Connor Jonathan Evans Robert Sutton John P. Neoptolemos	2010	Annals of Surgery2010，，5：	2
7	Adjuvant therapy for pancreatic cancer 显示文摘	Ghaneh P S1avin J Sutton R	2000	Swiss Surg2000，6，5：	1
8	Complications of pancreatic cancer resection显示文摘	Halloran CM Ghaneh P Bosonnet L	2002	Dig Surg2002，19，2：	1
9	Pancre- atic cancer bENT1 expression and survival from gem- citabine in patients from the ESPAC-3 trial显示文摘	GreenhalfW Ghaneh P Neoptolemos JP	2014	JNatl Can- cer Inst2014，106，1：	1
10	Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo显示文摘	Ghaneh P Greenhalf W Humphreys M	2001	Gene Ther2001，8，3：	1
11	Pancreaite pseudecysts in chroinc pancreatitis:endoscopic and surgical heatmant显示文摘	Edoardo Rosso E Alexakis N Ghaneh P	2003	Dig Surg2003，20，5：	1
12	Complications of pancreatic cancer resection 显示文摘	Halloran CM Ghaneh P Bosonnet L	2002	Dig Surg2002，19，2：	1
13	Minimally invasive retroperitoneal pancreatic necrosectomy显示文摘	Connor S Ghaneh P Raraty M	2003	Dig Surg2003，20，4：	1
14	Both HIV- and EIAV- based lentiviral vectors mediate gene delivery to pancreatic cancer cells and human pancreatic primary patient xenografts 显示文摘	Saraga G Mafficini A Ghaneh P	2007	Cancer Gene Ther2007，14，9：	1
15	Gemcitabine based combination chemotherapy in advanced pancreatic cancer-indirect comparison显示文摘	Sultana A Ghaneh P Cunningham D	2008	BMC Cancer2008，8，：	1
16	Biology and management of pancreatic cancer显示文摘	Ghaneh P Costel\|o E Neoptolemos JP	2008	Postgrad Med J2008，84，47：	1
17	The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in de-termining patient selection for staging laparoscopy in suspected peri-ampullary cancer显示文摘	Smith RA Bosonnet L Ghaneh P	2008	Surgery2008，143，5：	1
18	Molecular prog- nostic markers in pancreatic cancer 显示文摘	Ghaneh P Kawesha A Evans JD	2002	J Hepatobiliary Pancreat Surg2002，9，1：	1
19	Direct Activation of Cytosolic Ca 2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells显示文摘	John A. Murphy David N. Criddle Mark Sherwood Michael Chvanov Rajarshi Mukherjee Euan McLaughlin David Booth Julia V. Gerasimenko Michael G.T. Raraty Paula Ghaneh John P. Neoptolemos Oleg V. Gerasimenko Alexei V. Tepikin Gary M. Green Joseph R. Reeve Ole	2008	Gastroenterology2008，，2：	1
20	The Matrix Metalloproteinases and their inhibitors in the treatMent of pancreatic cancer显示文摘	JONES L GHANEH P HUMPHREYS M	1999	Ann N Y Acad Sci1999，880，30：	1

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