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| 1 | Stimulation of p38 MAPK by hormal preconditioning with atrial natriuretic peptide显示文摘AIM:Stress-activated signaling pathways responsible for hepatic ischemia reperfusion injury and their modulation by protective interventions are widely unknown.Preconditioning of rat livers with Atrial Natriuretic Peptide(ANP)attenuates ischemia reperfusion injury(Gerbes et al.Hepatology1998,18:1309-1317),SinANP has recently been shown to be a regulator of the p38MAPKpathway in endothelial cells(Kiemer et al.CircRes2002,90:874-881).aim of this thudy was to investigate activities of MAPK during ischemia and reperfusion and effects of ANP on MAPK.METHODS:Rat livers were perfused with KH-buffer in the presence or absence of ANP for 20min,kept in cold UWsloution for 24h,and reperfused forupto120min,Activities of p38MAPKand JNKwas determined by in vitro phosphorylation assays using MBP and c-jun as substrates.After SDS/PAGE electrophoresis,gels were quantified by phosphorimaging.RESULTS:Activity of p38MAPKin control organs decreased in the course of ischemia and reperfusion by85%,whereas ANPincreased p38 activity by up to 30-fold.JNKactivation of control livers increased in the course of ischemia and reperfusion by up to three-fold.This increase in JNK activrity was slightly elevated in ANP preconditioned organs.CONCLUSION:This work represents a systematic investigation of MAPK activation during liver ischemia and reperfusion.Employing ANP,for the first time a pharmacological approach to modulate these central signal transduction molecules is presented. | Alexandra K. Kiemer Stefanie Kulhanek-Heinze Tobias Gerwig Alexander L. Gerbes Angelika M. Vollmar | 2002 | World Journal of Gastroenterology2002，8，4： | 7 |
| 2 | Muscle force and fatigue in patients with sepsis and multiorgan failure显示文摘 | Eikermaim M Koch G Gerwig M | 2006 | Care Med2006，32，2： | 1 |
| 3 | Vitamin D receptor initiation codon polymorphism, bone density and inflammatory activity of patients with ankyiosing spnndylitis显示文摘 | Barbara M Uwe L Gerwig F | 2003 | Osteoporos Int2003，14，12： | 1 |
| 4 | Muscleforce and fatigue in patients with sepsis and multiorganfailure显示文摘 | EIKERMANN M KOCH G GERWIG M | 2006 | Intensive Care Med2006，32，2： | 1 |
| 5 | Structural basis for ligand and substrate recognition by torovirus hemagglutinin esterases显示文摘 | LANGEREIS M A ZENG Q GERWIG GJ | 2009 | Proc Natl Acad Sci USA2009，106，15： | 1 |
| 6 | Growth and carcass characteristics as well as meat and fat and fat quality of three types of pigs under different feeding regi- mens 显示文摘 | Affentranger P Gerwig C Seewer G J | 1996 | Livest Prod Sci1996，，45： | 1 |
| 7 | A lectin array-based methodology for the analysis of protein glycosylation显示文摘 | Rosenfeld R Bangio H Gerwig GJ | 2007 | J Biochm Biophy Methods2007，70，3： | 1 |
| 8 | A lectin array-based methodology for the analysis of protein glycosylation显示文摘 | Rakefet Rosenfeld Haim Bangio Gerrit J. Gerwig Revital Rosenberg Ronny Aloni Yossi Cohen Yehudit Amor Inbar Plaschkes Johannis P. Kamerling Ruth Ben-Yakar Maya | 2006 | Journal of Biochemical and Biophysical Methods2006，，3： | 1 |
| 9 | Cognitive functions in pa- tients with MR-defined chronic focal cerebellar lesions 显示文摘 | Richter S Gerwig M Asian B | 2007 | Journal of neurology2007，254，： | 1 |
| 10 | Growth and carcass characteristics as well as meat and fatquality of three types of pigs under different feeding regimens 显示文摘 | Affentranger P Gerwig C Serwig G J F | 1996 | Livest Prod Sci1996，45，： | 1 |
| 11 | Amplitude changes of unconditioned eyeblink responses in patients with cerebellar lesions显示文摘 | Gerwig M Dimitrova A Maschke M | 2004 | Exp Brain Res2004，155，3： | 1 |
| 12 | Structure determination of the exopolysaccharide of Lactobacillus fermentum TDS030603-A revision显示文摘 | Gerwig G J Dobruchowska Shi T | 2013 | Carbohyd Res2013，378，： | 1 |
| 13 | A lectin array-based methodology for the analysis of protein glycosylation 显示文摘 | Rosenfeld R Bangio H Gerwig GJ | 2007 | J Biochem Biophys2007，70，3： | 1 |
| 14 | The IBM eServer z990 Floating-Point Unit显示文摘 | Gerwig G Wetter H Schwarz E M | 2004 | IBM Journal of Research and Development2004，48，34： | 1 |
| 15 | The Giardia intestinalis filamentous cyst wall contains a novel β( 1-3)-N-acetyl-D-galactosamine polymer: a structural and conformational study显示文摘 | Gerwig G J van Kuik J A Leeflang B R | 2002 | Glycobiology2002，12，8： | 1 |
| 16 | Eyeblink conditioning in patients with hereditary ataxia:a one-year follow-up study显示文摘 | Timmann D Gerwig M Frings M | 2005 | Exp Brain Res2005，162，： | 1 |
| 17 | Rapid milk group classification by 1H NMR analysis of Le and H epitopes in human milk oligosaccharide donor samples 显示文摘 | Van Leeuwen S S Schoemaker R J Gerwig G J | 2014 | Glycobiology2014，24，8： | 1 |
| 18 | Ultracompact laser projection systems based on two-dimensional resonant microscanning mirrors显示文摘 | Andreas Bruer Klaus Frommhagen Christian Gerwig | 2008 | J Micro/Nanolith MEMS MOEMS2008，7，2： | 1 |
| 19 | The IBM Eserver z990 Floating-point Unit 显示文摘 | Gerwig G Wetter H Schwarz E M | 2004 | IBM Journal of Research and Development2004，48，34： | 1 |
| 20 | Influence of seasons, air mass origin and day of the week on size-segregated chemical composition of aerosol particles at a kerbside显示文摘 | BrUggemann E Gerwig H Gnauk T | 2009 | Atmosphefic Environment2009，43，： | 1 |
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