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| 1 | Role of E3 ubiquitin ligases in lung cancer显示文摘E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome.Therefore,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer development.However,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical setting.In this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung cancer.Furthermore,we discuss the processes in which they are involved and evaluate them as potential anti-cancer targets.By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients. | Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters | 2013 | World Journal of Clinical Oncology2013，4，3： | 5 |
| 2 | Postprandial blood hormone and metabolite concentrations influenced by feeding frequency and feeding level in veal calves显示文摘 | VICARI T VAN DEN BORNE J J G C GERRITS W J J | 2008 | Domestic Animal Endocrinology2008，34，： | 1 |
| 3 | Ultrasound ex- amination of pathological cervical lymph nodes in patients with non-Hodgkin' s lymphoma and Hodgkin' s disease 显示文摘 | Gerrits C J van Overhagen H van Lore K | 1994 | Br J Haematol1994，88，3： | 1 |
| 4 | Sucrose Metabolism in Plastids 显示文摘 | Nathalie Gerrits Stefan C H J Turk Kees P M van Dun | 2001 | Plant Physiology2001，125，2： | 1 |
| 5 | A GIS-based support tool for sustain- able spatial planning in metropolitan areas显示文摘 | Gerrit J C Arend L | 2007 | Landscape and Urban Planning2007，80，2： | 1 |
| 6 | Opposite contributions of glycinin and β-conglycinin derived peptides to the aggregation behavior of soy protein isolate hydrolysates显示文摘 | Kuipers Bas J H Gerrit A Arno C | 2006 | Food Biophysics2006，，1： | 1 |
| 7 | Postprandial blood hormone and metabolite concentrations influ-enced by feeding frequency and feeding level in veal calves 显示文摘 | VIEARI T VANDEN BORNE J J G C GERRITS W J J | 2008 | Domestic Animal Endocrinology2008，34，1： | 1 |
| 8 | Copper status in rats fed diets supplemented with either vitamin E, vitamin A, or β-carotene显示文摘 | Gerrit J V Lemmens A G Anton C B | 1993 | Biology Trace Element Research1993，37，： | 1 |
| 9 | A novel signaling pathway controlling induced systemic resistance in Arabidopsis显示文摘 | PIETERSE C M J VAN WEES S C M VAN PELT J A KNOESTER M LAAN R GERRITS H WEISBEEK P J VAN LOON L C | 1998 | Plant Cell1998，10，： | 1 |
| 10 | Thevalue of contrast and subtraction arthrography in the assessment ofaseptic loosening of total hip prostheses:A meta-analysis显示文摘 | Olivier P P Temmerman Ide C Heyligers Gerrit J J Teule | 2005 | Euro-pean Journal of Radiology2005，56，： | 1 |
| 11 | Gene duplication and conversion events shaped three homologous, differentially expressed myosin regulatory light chain (MLC2) genes显示文摘 | GERRITS L OVERHEUI G J DERKS R C | 2012 | Eur J Cell Biol2012，91，： | 1 |
| 12 | Induction of insulin re- sistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes 显示文摘 | Gerrits A J Gitz E Koekman C A | 2012 | Haematologica2012，97，8： | 1 |
| 13 | Chitosan and its derivatives in mucosal drug and vaccine delivery 显示文摘 | VAN DER LUBEN I M VERHOEF J C GERRIT B G | 2001 | Eur J Pharm Sci2001，14，3： | 1 |
| 14 | Signaling in equity crowdfunding显示文摘 | AHLERS Gerrit K C Cumming D J GUnther C | 2015 | Entrepreneurship theory and practice2015，39，4： | 1 |
| 15 | Copper status in rat fed diets supplemented with either vitamin E, vitamin A, or β-carotene 显示文摘 | GERRIT J V LEMMENS A G ANTON C B | 1993 | Biological Trace Ele- ment Research1993，37，： | 1 |
| 16 | A GIS-based tool for sustainable spatial planning in metropolitian areas 显示文摘 | Gerrit J C Ligtenberg A | 2007 | Landscape and Urban Planning2007，，80： | 1 |
| 17 | Sucrose Metabolism in Plastids 显示文摘 | Gerrits N Turk S C H J van Dun K P M | 2001 | Plant Physiology2001，125，2： | 1 |
| 18 | Copper status in rat fed diets supplemented with either vitamin E,vitamin A,or β-carotene 显示文摘 | Gerrit J V Arnoldina G Anton C B | 1993 | Biology Trace Element Research1993，37，： | 1 |
| 19 | Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas显示文摘BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important aspect.Knowledge of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)lesions.AIM To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 SD-CRCs.Molecular analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)mutations.APC mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in SD-CRCs.This indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs. | Manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian Rausch Esmée J Grobbee Manon van Engeland Manon C W Spaander Gerrit A Meijer Evelien Dekker | 2022 | World Journal of Gastrointestinal Oncology2022，14，11： | 0 |
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