|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Colon capsule endoscopy versus standard colonoscopy in assessing disease activity of ulcerative colitis: a prospective trial显示文摘 | T. Meister H. S. Heinzow D. Domagk A. Dortgolz F. Lenze M. Ross W. Domschke A. Lügering | 2013 | Techniques in Coloproctology2013，，6： | 4 |
| 2 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 3 | 现代汽车的能量管理系统显示文摘大陆集团开发的电源和能量管理系统除电子组件外,还包括相应的软件和控制策略。可以保证汽车电气系统各种条件下的正常工作状态-包括混合动力车和纯电动汽车,同时节省能源。 | Horst Gering | 2008 | 汽车与配件2008，，44： | 2 |
| 4 | Open reduction and imernal fixation of Mason type llI radial head fractures with and without an associ- ated elbow dislocation显示文摘 | Nalbantoglu U Koeaoglu B Gereli A | 2007 | J Hand Surg2007，32，10： | 1 |
| 5 | Computational analysis and experimental validation of tumor- associated alternative splicing in human cancer显示文摘 | Wang Z Lo H S Yang H Gere S Hu Y Buetow K H | 2003 | Cancer Res2003，63，： | 1 |
| 6 | Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos显示文摘 | Gering M Patient R | 2005 | Dev Cell2005，，8： | 1 |
| 7 | Computational analysis and experimental validation of tumor-associated alternative splicing in human cancer 显示文摘 | Wang Z Lo H S Yang H Gere S Hu Y Buetow K H | 2003 | Cancer Res2003，63，： | 1 |
| 8 | Hepatitis B virus infection and primary hepatocellular carcinoma显示文摘 | Tabor E Gerely RJ Voegel CL | 1977 | J Natl Cancer Jnst1977，58，5： | 1 |
| 9 | Equilibrium andkinetics for the sorption of promethazine hydrochlorideonto K10 montmorillonite 显示文摘 | Gereli G Seki Y Yurdakoc K | 2006 | J Colloid Interface Sci2006，299，1： | 1 |
| 10 | The effect of the PPARgamma ligand rosiglitazone on energy balance regulation显示文摘 | JOOSEN A M BAKKER A H GERING M J | 2006 | Diabetes Metab Res Rev2006，22，3： | 1 |
| 11 | Simulation of methane hydrate phenomena over geological timescales, Part Ⅰ: Effect of sediment compaction rates on methane hydrate and free gas accumulations 显示文摘 | Gering K L | 2003 | Earth and Planetary Science Letters2003，206，： | 1 |
| 12 | A rapid method for counting nucleated erythrocytes on stained blood smears by digital image analysis显示文摘 | Gering E Atkinson CT | 2004 | J Parasitol2004，90，4： | 1 |
| 13 | Influence of oxidative stress and metabolic adaptation on PON1 activity andMDA level in transition dairy cows 显示文摘 | Turk R Juretic D Geres D | 2008 | Animal Reproduction Science2008，108，： | 1 |
| 14 | 47 A显示文摘 | Kelker MS Foss TR Peti W Crystal structure of human trig gering receptor expressed on myeloid cells (TREM-1) at 1 | 2004 | J Mol Bid2004，342，4： | 1 |
| 15 | Arthroseopic inspection after the surgical treatment of patella fractures 显示文摘 | Haklar U Kocaoglu B Gereli A | 2009 | Int Orthop2009，33，3： | 1 |
| 16 | Faces of suburbaniza- tion:residential location choice at the urban fringe显示文摘 | Cunningham C Espey M Gering L R | 2007 | Review of A- gricultural Economics2007，29，3： | 1 |
| 17 | The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in human显示文摘 | BL ECH S Ebner T Ludwig-Schwell IN GERE | 2008 | Drug Metab Dispos2008，36，： | 1 |
| 18 | Treatment for distal tibial fractures with intramedullary nails and blocking screws显示文摘 | Seyhan M Kocaoglu B Gereli A | | 0，，： | 1 |
| 19 | Arterial hypertension 2007: guidelines for themanagement of arterial hypertension 显示文摘 | Gere V Buksa M | 2007 | Med Arh2007，61，21： | 1 |
| 20 | Recent understanding of IBD pathogenesis: Implications for future therapies显示文摘 | TorstenKucharzik ChristianMaaser AndreasLügering MartinKagnoff LloydMayer StephanTargan WolframDomschke | 2006 | Inflamm Bowel Dis2006，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员