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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The time frame for development from premalignant to malignant disease typically spans 10-15 years,and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes.Currently,early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for populationbased screening.New blood-based protein biomarkers for early detection of CRC are therefore urgently required.The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental,analytical,and biological factors that can interfere with the robust interpretation of results.In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies.Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC. | Kim YC Fung Edouard Nice Ilka Priebe Damien Belobrajdic Aloke Phatak Leanne Purins Bruce Tabor Celine Pompeia Trevor Lockett Timothy E Adams Antony Burgess Leah Cosgrove | 2014 | World Journal of Gastroenterology2014，20，4： | 2 |
| 3 | 丙型肝炎病毒的流行与结构——HCV所致肝细胞癌会议概述显示文摘本文介绍了1991年3月由日本和美国从事丙型肝炎病毒(HCV)研究的专家参加的丙型肝炎病毒所致肝细胞癌(HCC)会议的概况.这次会议主要探讨了HCV与HCC的相关性,HCV的基因组结构,HCV的株变异,测定HCV感染的方法及抗HCV的治疗方法等.会议旨在通过交流最新研究进展,以加快了解HCC的病因. | Tabor E 侯莉 张景云 | 1992 | 国外医学(流行病学.传染病学分册)1992，19，4： | 2 |
| 4 | A new catalytically active colloidal platinum nanocatalyst: the multi- armed nanostar single crystal显示文摘 | MAHMOUD M A TABOR C E EL-SAYED M A | 2008 | Journal of the American Chemi- cal Society2008，130，14： | 1 |
| 5 | Escherichia coli thiore- doxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7 显示文摘 | TABOR S HUBER H E RICHARDSON C C | 1987 | J Biol Chem1987，262，16： | 1 |
| 6 | Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infee- tion显示文摘 | Biswas R Tabor E Hsia CC | 2003 | Transfusion2003，43，6： | 1 |
| 7 | Increased expression of transforming growth factor α after transfection of a human hepatoblastoma cell line with the hepatitis B virus显示文摘 | Tabor E Earshid M Di Bisceglie A | 1992 | J Med Virol1992，37，： | 1 |
| 8 | Hepatitis B virus infection and primary hepatocellular carcinoma显示文摘 | Tabor E Gerely RJ Voegel CL | 1977 | J Natl Cancer Jnst1977，58，5： | 1 |
| 9 | Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1 显示文摘 | Tabor D E Kim J B Spiegelman B M | 1998 | J Biol Chem1998，273，22： | 1 |
| 10 | Metallosalen complexes immobilized in zeolite NaX as catalysts of aerobic oxidation of cyclooctane显示文摘 | PAMIN K TABOR E HABER J ADAMSKI A SOJKA Z | 2006 | Appl Catal A2006，299，： | 1 |
| 11 | Deletion mutants of the hepatitis B virus X gene in human hepatocellular carcinoma 显示文摘 | Hsia CC Nakashima Y Tabor E | 1997 | Biochem Biophys Res Commun1997，241，3： | 1 |
| 12 | The crystal structure of poly-p-phenylene sulfide 显示文摘 | Tabor B J Magre E P Boon J | 1968 | European Polymer Journal1968，，7： | 1 |
| 13 | Tumor suppressor genes,growth factor genes,and oncogenes in hepatitis B virus-associnated hepatocellular carcinoma显示文摘 | Tabor E | 1994 | J Med Virol1994，42，4： | 1 |
| 14 | Nine-year follow-up study of a plasma-derived hepatitis B vaccine in a rural Africa setting显示文摘 | Cairns J Robert J | 1993 | J Med Virol1993，40，： | 1 |
| 15 | Nine-year follow-up study of a plasma-derived hepatitis B vaccine in a rural African setting显示文摘 | Tabor E Cairns J Gerety R J Bayley AC | 1993 | J Med Virol1993，40，： | 1 |
| 16 | Summary of a workshop on the implementation of NAT to screen donors of blood and plasma for viruses 显示文摘 | Tabor E Yu MY Hewlett I | 2000 | Transfusion2000，40，10： | 1 |
| 17 | Non-A, non-B hepatitis: new findings and prospects for prevention显示文摘 | Tabor E Gerety RJ | 1979 | Transfusion1979，19，6： | 1 |
| 18 | Fetal loss rate after chorionic villus sampling and amniocentesis: an 11-year national registry study 显示文摘 | Tabor A Vestergaard CH Lidegaard E | 2009 | Ultrasound Obstet Gynecol2009，34，1： | 1 |
| 19 | S-adenosylmethionine synthetase from Escherichia coli显示文摘 | MAKHAM G D HAFNER E W TABOR C W | 1980 | J Biol Chem1980，255，： | 1 |
| 20 | Infections by hepatitis B surface antigen gene mutants in Europe and North America显示文摘 | Tabor E | 2006 | J Med Virol2006，781，： | 1 |
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