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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | Microarray analysis of differentially expressed genes in placental tissue of preeclampsia:up-regulation of obesity-related genes显示文摘 | Koczan D Gerber B | 2002 | Mol Hum Reprod2002，8，： | 1 |
| 3 | Rifampin reduces production of reactive oxygen species of cerebrospinal fluid phagocytes and hippocampal neuronal apoptosis in experimental Streptococcuspneumoniae meningitis显示文摘 | BOTTCHER T GERBER J WELLMER A | 2000 | J Infect Dis2000，181，20： | 1 |
| 4 | Expression of HLA class I antigens on hepatocytes in liver disease显示文摘 | Fukusato T Gerber MA Thung SN | 1986 | Am J Pathol1986，123，2： | 1 |
| 5 | A PCV2 vaccine based on genotype 2b is more effective than a 2a-based vaccine to protect against PCV2b or combined PCV2a/2b viremia in pigs with concurrent PCV2,PRRSV and PPV infection显示文摘 | Opriessnig T ONeill K Gerber P F | 2013 | Vaccine2013，31，3： | 1 |
| 6 | Quantitative as- sessment of intrinsic regional myocardial deformation by Doppler strain rate echocardiography in humans: validation against three-dimensional tagged magnetic resonance imag- ing显示文摘 | Edvardsen T Gerber BL Garot J | 2002 | Circulation2002，106，1： | 1 |
| 7 | Measurement of myocardial infarct size by electron beam computed tomography:a comparison with 99mTc sestamibi显示文摘 | Schmermund A Gerber T Behrenbeck T | 1998 | Invest Radiol1998，33，6： | 1 |
| 8 | Differential regulation of toll-like receptor mRNAs in experimental murine central nervous system infections显示文摘 | Bottcher T yon Mering M Ebert S Meyding-Lamade V Kuhnt V Gerber J | 2003 | Neurosci Lett2003，344，1： | 1 |
| 9 | Angiographically silent plaque in the left main coronary ar tery detected by intravascular ultrasound显示文摘 | Ge J Liu F Gerber T | 1995 | Coron Artery Dis1995，6，： | 1 |
| 10 | Calculated versus measured creatinine clearance for dosing methotrexate in the treatment of primary central nervous system lymphoma 显示文摘 | Gerber DE Grossman SA Batchelor T | 2007 | Cancer Chemother Pharmacol2007，59，6： | 1 |
| 11 | Target validation for genomics using peptide-specific phage antibodies: A study of five gene products overexpressed in colorectal cancer 显示文摘 | VAN BEIJNUM J R MOERKERK P T M GERBERS A J | 2002 | Int J Cancer2002，101，2： | 1 |
| 12 | Functional analysis of the leukemia protein ELL:evidence for a role in the regulation of cell growth and survival显示文摘 | Johnstone RW Gerber M Landewe T | 2001 | Mol Cell Biol2001，21，5： | 1 |
| 13 | Arrhythmogenic right ventricular cardiomyopathy/dysplasia:A not so rare 'disease of the desmosome' with multipte clinical presentations显示文摘 | Herren T Gerber PA Duru F | 2009 | Clin Res Cardiol2009，98，3： | 1 |
| 14 | Human mesenchymal stem cells inhibit endothelial proliferation and angiogenesis via cell-cell contact through modulation of the VE-Cadherin/β-catenin signaling pathway 显示文摘 | Menge T Gerber M Wataha K | 2013 | Stem Cells Dev2013，22，1： | 1 |
| 15 | A PCV2 vaccine based on genotype 2b is more effective than a 2a based vaccine to protect against PCV2b or corn-bined PCV2a/2b viremia in pigs with concurrent PCV2, PRRSV and PPV infection显示文摘 | Opriessnig T O~Neill K Gerber P F | 2013 | Vaccine2013，31，3： | 1 |
| 16 | Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans 显示文摘 | Luginbfuhl M Gerber A Schnider T W | 2003 | Anesth Analg2003，96，3： | 1 |
| 17 | Microarray analysis of differentially expressed genes in placental tissue of preeclampsia: up-regulation of obesity-related genes 显示文摘 | Reimer T Koczan D Gerber B | 2002 | Mol Hum Reprod2002，8，7： | 1 |
| 18 | Two domains of MyoD mediate transcriptional activation of genes in repres- sive chromatin: A mechanism for lineage determination in myogenesis显示文摘 | GERBER A N KLESERT T R BERGSTROM D A | 1997 | Genes & Development1997，11，4： | 1 |
| 19 | Quantitative assessment of intrinsic regional myocardial deformation by Doppler strain rate echocardiography in humans:validation against three-dimensional tagged magnetic resonance imaging显示文摘 | Edvardsen T Gerber BL Garot J | 2002 | Circulation2002，106，1： | 1 |
| 20 | Livestoek's long shadow: environmental issues and options显示文摘 | Steinfeld H Gerber P Wassenaar T | 2006 | Rome: Food and Agriculture Organization of United Nations: 2006:124-1792006，，： | 1 |
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