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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 3 | Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence显示文摘BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related mortality.Classifying clinical parameters that increase risk for recurrence after IBTR remains a challenge.AIM To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease outcomes.METHODS Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our institution.Overall survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan Meier method.We identified patients who experienced an isolated IBTR.Concordance of hormone receptor status and location of tumor from primary to recurrence was evaluated.The effect of clinical and treatment parameters on disease outcomes was also evaluated.RESULTS We identified 2164 patients who met the eligibility criteria.The median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]years.Five-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 IBTRs.We identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ component.Median time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)years.Radiotherapy information was available for 30 of 37 patients.Median whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor bed.Twenty-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly associated.There were no observed changes in HER-2 status from primary to IBTR.The concordance between quadrant of primary to IBTR was 10/19[(62.2%),P=0.008].Tumor size greater than 1.5 cm(HR=0.44,95%CI:0.22-0.90,P=0.02)and use of endocrine therapy upfront(HR=0.36,95%CI:0.18-0.73,P=0.004)decreased the risk of IBTR.CONCLUSION Among patients with early stage breast cancer who had breast conserving surgery treated with adjuvant RT,ER/PR status and quadrant were highly concordant from primary to IBTR.Tumor size greater than 1.5 cm and use of adjuvant endocrine therapy were significantly associated with decreased risk of IBTR. | Juhi M Purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber | 2020 | World Journal of Clinical Oncology2020，11，1： | 2 |
| 4 | Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics 显示文摘 | Lampertico P Maher J S Gerber M A | 1991 | Hepatology1991，13，3： | 1 |
| 5 | Numerical investigation of the influence of rock shape on rockfall trajectory显示文摘 | Glover J Schweizer A Christen M Gerber W Leine R Bartelt P | 2012 | Geophysical Research Abstracts2012，14，11： | 1 |
| 6 | A study ofclients returning for counseling after HIV testing: implica-tions for improving rates of return 显示文摘 | Valdiserri RO Moore M Gerber AR | 1993 | Public Health Rep1993，108，1： | 1 |
| 7 | Gravity gradiometry 显示文摘 | Gerber M A | 1978 | Astronautics and Aeronau- tics1978，16，： | 1 |
| 8 | Biome- chanical assessment of anterior lumbar interbody fusion with an anterior lumbosacral fixation screw-plate:comparison to stand-alone anterior lumbar inter-body fusion and anterior lumbar interbody fusion with pedicle screws in an unstable human cadaver model显示文摘 | Gerber M Crawford NR Chamberlain RH | 2006 | Spine2006，31，7： | 1 |
| 9 | I)iagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever,Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart As- sociation显示文摘 | Newburger JW Takahashi M Gerber MA | 2004 | Pediatrics2004，114，6： | 1 |
| 10 | Validation of an immunoperoxidase monolayer assay for total anti-Vac- cinia virus antibody titration 显示文摘 | Gerber P F Matos A C Guedes M I | 2012 | J Vet Diagn Invest2012，24，2： | 1 |
| 11 | Theoretical study of decomposition pathway for HArF and HKrF显示文摘 | CHABAN G M LUNDELL J GERBER R B | 2002 | J Chem Phys Lett2002，364，： | 1 |
| 12 | Differential regulation of toll-like receptor mRNAs in experimental murine central nervous system infections显示文摘 | Bottcher T yon Mering M Ebert S Meyding-Lamade V Kuhnt V Gerber J | 2003 | Neurosci Lett2003，344，1： | 1 |
| 13 | Diagnosis, treament, and long-term management of Kawasaki disease: a statement for health professionals from the committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association显示文摘 | Newburger JW Takahashi M Gerber MA | 2004 | Pediatrics2004，114，6： | 1 |
| 14 | Diagnosis, treatment, and long-term management of Kawasakidisease ; a statement for health professionals from the Committeeon Rheumatic Fever, Endocarditis and Kawasaki Disease,Council on Cardiovascular Disease in the Young, AmericanHeart Association 显示文摘 | NEWBURGER J W TAKAHASHI M GERBER M A | 2004 | Circulation2004，110，17： | 1 |
| 15 | Diagnosis, Treatment, and longterm management of Kawasaki disease:a statement for health professionals from the committee on rheumatic fever, endocarditis and Kawasaki disease, council on cardiovascular disease in the Young, American Heart Association 显示文摘 | Newburger JW Takahashi M Gerber MA | 2004 | Circulation2004，110，17： | 1 |
| 16 | Anesthesia and periinterventional morbidity of rigid bronchoscopy for tracheobronchial foreign body diagnosis and removal显示文摘 | Tomaske M Gerber AC Weiss M | 2006 | Paediatr Anaesth2006，16，： | 1 |
| 17 | Cryptosporidial infections after solid organ transplantation in children显示文摘 | Gerber DA Green M Jaffe R | 2000 | Pediatr Transplant2000，4，1： | 1 |
| 18 | Diagnosis, treatment, and long - term management of Kawasaki disease : A statement for health pro- fessionals from the Committee on Rheumatic Fever, Endocarditis and Ka- wasaki Disease, Council on Cardiovascular Disease in the Young, Ameri- can Heart Association 显示文摘 | Newburger JW Takahashi M Gerber MA | 2004 | Circulation2004，110，17： | 1 |
| 19 | The use of hyperbaric oxygen in urology 显示文摘 | Capelli-Schellpfeffer M Gerber GS | 1999 | J Urol1999，162，31： | 1 |
| 20 | Chemokine recep-tor specific for IP10 and mig: structure, function,and expres-sion in activated Tlymphocytes显示文摘 | Loetscher M Gerber B Loetscher P | 1996 | J Exp Med1996，184，3： | 1 |
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