4篇
您的检索式：作者名="Gerard Valentin"
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| 1 | Targeting glial physiology and glutamate cycling in the treatment of depression显示文摘 | Gerald W Valentine Gerard Sanacora | | 0，，05： | 1 |
| 2 | Direct electrochemical preparation of solid potassium ferrate 显示文摘 | Francois Lapicque Gerard Valentin | 2002 | Electrochemistry Communications2002，，4： | 1 |
| 3 | Noninvasive In Vivo Human Coronary Artery Lumen and Wall Imaging Using Black-Blood Magnetic Resonance Imaging显示文摘 | Zahi A. Fayad Valentin Fuster John T. Fallon Timothy Jayasundera Stephen G. Worthley Gerard Helft J. Gilberto Aguinaldo Juan J. Badimon Samin K. Sharma | 2000 | Circulation: Journal of the American Heart Association2000，，5： | 1 |
| 4 | Interleukin-17A blockade with secukinumab results in decreased neutrophil infiltration in psoriasis: minimally-invasive measurement by tape stripping显示文摘Psoriasis is a well characterized interleukin (IL)-17A-driven skin disease with neutrophil infiltration and epidermal hyperkeratosis. Several biomarkers, most prominently β-defensin-2 (BD-2), have been identified using local and systemic invasive measurements as responsive markers of IL-17A-driven skin pathology. We sought to determine whether measurements of epidermal proteins by tape stripping could offer a minimally-invasive method to assess treatment responses. We compared the expression of 170 proteins in the epidermis (tape stripping) and dermis (open flow microperfusion) of 8 psoriatic subjects before and after administration of a single dose of subcutaneous (s.c.) anti- IL-17A mAb secukinumab. Proteomic analyses of tape strips revealed a >3-fold decrease in 32 epidermal and inflammatory cell proteins in response to secukinumab. The epidermal proteins with the largest (>10-fold) decreases were: matrix metalloproteinase-8 (MMP-8, 15.68-fold, p<0.05);myeloperoxidase (MPO, 14.72-fold, p<0.005);IL-8 (11.93-fold, p<0.05);MMP-9 (10.81-fold, p<0.005);and IL-1β(10.35-fold, p<0.05). For these proteins, greater-fold protein changes were detected in the epidermis compared to dermis. Immunohistochemical analysis confirmed that neutrophils are the predominant cell type in psoriatic skin lesions that express MPO, MMP-8 and MMP-9, and that secukinumab treatment dramatically decreases neutrophil accumulation. Thus, tape stripping may be used to assess epidermal neutrophils, and protein biomarker responses to anti-IL-17A therapy in psoriasis. | Christian Loesche Frank Kolbinger Marie-Anne Valentin Philip Jarvis Melanie Ceci Grazyna Wieczorek Edward Khokhlovich Irina Koroleva Gerard Bruin Frank Sinner Birgit Aigner Dhavalkumar D Patel | 2016 | Advances in Precision Medicine2016，1，2： | 0 |
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