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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 4 | Apractical guide to ass- essment of ventricular diastolic function using Doppler echocar- diography显示文摘 | Gerald I C Joseph F P James D T | 1996 | JACC1996，27，7： | 1 |
| 5 | Investigation of nanoporous carbon powders produced by high energy ball milling and formation of carbon nanotubes during subsequent annealing显示文摘 | Y CHEN J FITZ GERALD L T CHADDERTONL and L CHAFFRON | 1999 | Journal of Metastable and Nanocrystalline Materials1999，2，： | 1 |
| 6 | Roles of interleuckin-13 and interferon-γ in lung inflammation 显示文摘 | Gabriele G Gerald J Dale T | 2000 | Chest2000，121，2： | 1 |
| 7 | Evolutionary reinforcementlearning of artificial neural networks显示文摘 | Nils T Siebel Gerald Sommer | 2007 | Int Journal HybridIntelligent Systems2007，4，3： | 1 |
| 8 | The future renewable electric energy delivery and management system: the energy internet 显示文摘 | Alex H Mariesa L C Gerald T H | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 9 | A solid state process for formation of boron nitride nanotubes 显示文摘 | CHEN Y CHADDERTON L T GERALD J F | 1999 | Appl Phys Lett1999，74，： | 1 |
| 10 | Immune function during space flight显示文摘 | Gerald Sonnenfeld William T Shearer | 2002 | Nutr2002，18，： | 1 |
| 11 | Faultcurrent contribution from synchronous machine andinverter based distributed generators显示文摘 | NATTHAPHOB N GERALD T H RAJA A | 2007 | IEEE Trans onPower Delivery2007，22，1： | 1 |
| 12 | Roles of interleuckin13 and interferon-γ in lung inflammation显示文摘 | Gabriele G Gerald J Dale T | 2000 | Chest2000，121，2： | 1 |
| 13 | A Solid-state process for formation of boron nitride 显示文摘 | Chen Y Chadderton L T Gerald J F | 1999 | Appl Phys Lett1999，74，： | 1 |
| 14 | Technical basis and proposal for deriving sediment quality criteria for metals显示文摘 | Gerald T A Dominic M D T David J H | 1996 | Environmental Toxicology and Chemistry1996，15，12： | 1 |
| 15 | Preparation and characterization of LDPE and PP-wood fiber composites 显示文摘 | Munir Ta dem r Hasan Bihekin Gerald T Caneba | 2009 | Journal of Applied Polymer Science2009，112，5： | 1 |
| 16 | Nanoporous carbon produced by ball milling 显示文摘 | Chen Y Gerald J F Chadderton L T | 1999 | Applied physics letters1999，74，： | 1 |
| 17 | Exsolution in hornblende and its consequence for 40Ar-39Ar age spectra and closure temperature显示文摘 | Harrison T M Fitz Gerald J D | 1986 | Geochim Cosmochim Acta1986，50，： | 1 |
| 18 | Studies of inclusion complexes of natural and modified cyclodextrin whh (+)catechin by NMR and molecular modeling显示文摘 | SEBASTIAN M GERALD Z T | 2007 | Bioorganic & Medidnal Chemistry2007，15，9： | 1 |
| 19 | Roles of interleuckin-13 and interferon-酌 in lung inflammation显示文摘 | Gabriele G Gerald J Dale T | | 0，，03： | 1 |
| 20 | Roles of interleuckin-13 and interferon-γ in lung inflammation显示文摘 | Gerald J Dale T | 2000 | Chest2000，121，2： | 1 |
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