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| 1 | Global myocardial strain assessment by different imaging modalities to predict outcomes after ST-elevation myocardial infarction:A systematic review显示文摘AIM: To conduct a systematic review relating myocardial strain assessed by different imaging modalities for prognostication following ST-elevation myocardial infarction(STEMI).METHODS: An online literature search was performed in Pub Med and OVID® electronic databases to identify any studies that assessed global myocardial strain parameters using speckle-tracking echocardiography(STE) and/or cardiac magnetic resonance imaging(CMR) techniques [either myocardial tagging or feature tracking(FT) software] in an acute STEMI cohort(days 0-14 post-event) to predict prognosis [either development of major adverse cardiac events(MACE)] or adverse left ventricular(LV) remodelling at follow-up(≥ 6 mo for MACE,≥ 3 mo for remodelling). Search was restricted to studies within the last 20 years. All studies that matched the pre-defined search criteria were reviewed and their results interpreted. Due to considerable heterogeneity between studies,metaanalysis was not performed.RESULTS: A total of seven studies(n = 7) were identified that matched the search criteria. All studies used STE to evaluate strain parameters- five(n = 5) assessed global longitudinal strain(GLS)(n = 5),one assessed GLS rate(GLS-R)(n = 1) and one assessed both(n = 1). Three studies showed that GLS independently predicted the development of adverse LV remodelling by multivariate analysis- odds ratio between 1.19(CI: 1.04-1.37,P < 0.05) and 10(CI: 6.7-14,P < 0.001) depending on the study. Four studies showed that GLS predicted the development of MACE- hazard ratio(HR) between 1.1(CI: 1-1.1,P = 0.006) and 2.34(1.10-4.97,P < 0.05). One paper found that GLS-R could significantly predict MACEHR 18(10-35,P < 0.001)- whilst another showed it did not. GLS <-10.85% had sensitivity/specificity of 89.7%/91% respectively for predicting the development of remodelling whilst GLS <-13% could predict the development of MACE with sensitivity/specificity of 100%/89% respectively. No suitable studies were identified that assessed global strain by CMR tagging or FT techniques.CONCLUSION: GLS measured acutely post-STEMI by STE is a predictor of poor prognosis. Further research is needed to show that this is true for CMR-based techniques. | Abhishek Shetye Sheraz A Nazir Iain B Squire Gerald P McCann | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Leptin is a four - helix bundle:secondary structure by NMR显示文摘 | Allen D K Gerald W B Lisa M C | 1997 | FEBS Letters1997，407，2： | 1 |
| 4 | Optimal Power Flow Emulation of Interchange Brokerate Systems Using Linear Programming显示文摘 | Georage F Gerald B S | 1992 | IEEE Transactions on Power System1992，7，2： | 1 |
| 5 | NonParametric tests for trends in wa- ter quality 显示文摘 | Gerald V B James P H | 2001 | Water Resources Research2001，37，4： | 1 |
| 6 | The effects of ω3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial显示文摘 | Trevor A Mori Valerie Burke Ian B Puddey Ashley B Irish Christine A Cowpland Lawrence J Beilin Gursharan K Dogra Gerald F Watts | 2009 | Journal of Hypertension2009，，9： | 1 |
| 7 | Electricity market dynamics: Oligopolistic competition显示文摘 | Gutierrez-Alcaraz G Gerald B S | 2006 | Electric Power Systems Research2006，76，： | 1 |
| 8 | Climate assessment for 1997显示文摘 | GERALD D B MICHAEL S H | 1998 | Bulletin of the American Meteorological Society1998，79，5： | 1 |
| 9 | Multiple complications in multiple myeloma显示文摘 | Seema B Gerald S Agnes B | 2005 | American Journal of Kidney Diseases2005，45，11： | 1 |
| 10 | Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis 显示文摘 | Gerald LN Nancy B James JLC | 2011 | Bioorg Med Chem2011，19，13： | 1 |
| 11 | Porcine reproductive and respiratory syndrome virus (PRRSV) infection in wild boars 显示文摘 | Gerald R Christina F Sebastian B | 2009 | Veterinary microbiology2009，136，： | 1 |
| 12 | Does Perceived Organizational Support Mediate the Relationship between Procedural Justice and Behavior? 显示文摘 | Robert H M Gerald L B Brian P N | 1998 | Academy of Organizational Citizenship Management Journal1998，41，3： | 1 |
| 13 | Genetic algorithm solution of economic dispatch with valve point loading显示文摘 | David C Walters Gerald B Sheble | 1993 | IEEE Trans on Power System1993，8，3： | 1 |
| 14 | Effect of angiogenesis inhi- bition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors显示文摘 | Ruzinova M B Schoer R A Gerald W | 2003 | Cancer Cell2003，4，10： | 1 |
| 15 | Trifluoroantipyrene 显示文摘 | Gerald F G Siegfried A Donald G B | 1958 | J Org Chem1958，23，： | 1 |
| 16 | Frenkel Selenium compounds prevent the induction of drug resistance by cisplatin in human ovarian tumor xenograft in vivo显示文摘 | Paula B Caffrey Gerald D | 2000 | Cancer Chemother Pharmacol2000，46，： | 1 |
| 17 | Precision DC-to-AC power conversion by optimization of the output current waveform-the half bridge revisited显示文摘 | GERALD R S KENNETH M B | 1999 | IEEE Trans on Power Electronics1999，14，2： | 1 |
| 18 | Biodegradation of 2,4- dinitrotoluene using poultry litter leachate 显示文摘 | Gian G Hemalatha B Gerald K et ol | 2004 | Journal of Hazardous Materials2004，113，13： | 1 |
| 19 | Genetic algorithm solution of economic dispatch with valve point loading显示文摘 | DAVID C W GERALD B S | 1993 | IEEE Transactions on Power Systems1993，8，3： | 1 |
| 20 | Mer- cury fraetionation, bioavailability, and ecotoxicity in high-ly contaminated soils from chlor-alkali plants 显示文摘 | Gerald J Z Carmen-Mihaela N Christian B | 2006 | Envi- ronmental Toxicology and Chemistry2006，25，4： | 1 |
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