|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 肝星状细胞中细胞凋亡和存活的信号调控(英文)显示文摘肝星状细胞(hepatic stellate cells,HSCs)在肝脏纤维化发生过程中起着关键作用。当正常肝脏受到损伤时,HSCs由静息状态转分化为类肌成纤维细胞,并保持这种处于激活状态的表型,它们接收到的凋亡和存活的生物信号将决定激活态HSCs的最终细胞寿命。HSCs凋亡的发生与一系列复杂而又相互关联的生物信号传导和调控有关,HSCs凋亡信号来自于细胞膜受体,如死亡受体、神经生长因子受体和外周型苯甲二氮卓受体(peripheral-type benzodiazepine receptor) ;以及胞浆蛋白,如Bcl-2家族蛋白和细胞周期蛋白等。HSCs存活信号受到多种激酶和细胞因子的诱导,如金属蛋白酶组织抑制剂-1(tissue inhibitors of metalloproteinase-1)、Rho/Rho激酶、血小板源生长因子(platelet-derived growth factor)、转化生长因子-β1 (transforming growth factor-β1 )和胰岛素样生长因子(insulin-like growth factor-1)等。特异性地诱导HSCs发生凋亡是治疗肝脏纤维化的直接和有效手段,虽然目前对HSCs由激活态到静息状态的转归尚需进一步研究,但诱导HSCs凋亡将是治疗肝脏纤维化和肝硬化的研究热点和主要发展方向。 | Hong Shen Jianghong Fan Geraid Minuk Yuewen Gong | 2007 | 中南大学学报(医学版)2007，32，5： | 2 |
| 2 | Corticosteroids and tubercuiosis:risks and use as adjunct therapy显示文摘 | Alzeer JM Geraid F | 1993 | Tubercle and lung Disease1993，74，1： | 1 |
| 3 | Distinct age and landscape influence on two reservoirs under the same climate 显示文摘 | GeraIdes A M Boavida M J | 2003 | Hydrobiologia2003，504，1： | 1 |
| 4 | Discriminating among subgroups of borderline personality disorder: An assessment of object representation显示文摘 | Geraid T Rafael A Javier& Mima C | 2003 | The American Journal of Psychoanaly- sis2003，63，2： | 1 |
| 5 | Planning and design of passing lanes using simulationmodel显示文摘 | Morrall John Miller Jr Edward Smith Geraid A | 1995 | Journal of Transportation Engineering1995，121，： | 1 |
| 6 | Effects of NADH and H2O2 on chromate induced human erythrocytes hemoglobin oxidation and peroxidation 显示文摘 | Fernandes MA Geraides CF Oliveira CR | 2000 | Ecotoxicol Environ Saf2000，47，1： | 1 |
| 7 | Isolation and characterization of melanized fungi from limestone formations in Mallorea显示文摘 | Constantino R Gonzalo P Geraid F B | | 0，，01： | 1 |
| 8 | Stem-cell protein Piwil2 is widely expressed in tumor and inhibits apoptosis through activation of Stat3/Bcl-xL pathway显示文摘 | Lee JH Dorothea S Geraid W | 2006 | Human Molecular Genetics2006，5，2： | 1 |
| 9 | Human proinsulin,a novel insulin agonist and intermediate in the synthesis of biosynthetic human insulin显示文摘 | Willian F H Fama M B Geraid S B | 1992 | J Biol Chem1992，267，1： | 1 |
| 10 | Using enzymes to improve the process and product quali- in the recycled paper industry, Part two: Industrial applications显示文摘 | Jean---Claude Pommier Geraid Goma Jean--Luc Fuentes | 1990 | TAPPI Journal1990，73，2： | 1 |
| 11 | Activation of protein kinase Cisofoms and its impact on diabeticom placation 显示文摘 | Geraides P | 2010 | Circ Res2010，30，4： | 1 |
| 12 | Coben Proximal third tibial shaft fracture显示文摘 | Geraid Jlang Brur E | 1995 | Clin Orthop1995，315，： | 1 |
| 13 | Using enzymes to improve the process and product quality in the recycled paper industry, Part two: Industrial applications 显示文摘 | Jean-Claude Pommier Geraid Goma Jean-Luc Fuentes | 1990 | TAPPI Journal1990，73，2： | 1 |
| 14 | Clinical practice gaidelines for hospital acquired pneumonia and ventilator- associated pneumonia in adults显示文摘 | Colemen Rotstein Geraid Evans Abraham Born | 2008 | Can J Infect Dis Med Microbi- ol Jan2008，，： | 1 |
| 15 | Activation of protein kinase C iso- foms and its impact on diabeticom plication 显示文摘 | Geraides P | 2010 | Circ res2010，30，4： | 1 |
| 16 | Implementation issues in tuberculosis/HIV program collaboration and integration: 3 ease studies 显示文摘 | Geraid F Anthony H David C | 2007 | The Journal of Infectious Diseases2007，196，1： | 1 |
| 17 | Regulation of neuronal T-type calcilum channels显示文摘 | Micea C L Geraid W Z | 2009 | Trends Pharm Sci2009，30，1： | 1 |
| 18 | Using enzymes to improve the process and product quality in the recycled paper industry, Part twoc Industrial applications显示文摘 | Jean-Claude Pommier Geraid Goma Jean-Luc Fuentea | 1990 | TAPPI Journal1990，73，2： | 1 |
| 19 | A Pratical Cuideto Assessment of Ventricular Diastolic Function Using Doppler Echecardiography显示文摘 | Geraid I Cohen M D | 1996 | JACC1996，27，7： | 1 |
| 20 | Modeling the SO2-slurry droplet reaction显示文摘 | GERAID H NEWTON | 1990 | AIChE1990，36，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员