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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Effect of rain infiltration on the stability of slopes 显示文摘 | Alonso E Gens A Lioret A | 1995 | Unsaturated Soils1995，，1： | 1 |
| 3 | A constituteive model for partically saturated soils显示文摘 | Gens A Josa A | 1990 | Geotechnique1990，40，3： | 1 |
| 4 | A constitutive model for partially saturated soils显示文摘 | Alonso E E Gens A Josa A | 1990 | Geotechnique1990，40，3： | 1 |
| 5 | A constitutive model for partially saturated soils显示文摘 | ALONSO E E GENS A JOSA A | 1990 | Grotechnique1990，40，3： | 1 |
| 6 | A constitutive model for partially saturated soils显示文摘 | ALONSO E E GENS A JOSA A | 1990 | Geotechnique1990，40，3： | 1 |
| 7 | Network model and optimization of reverse logistics by hybrid genetic algorithm 显示文摘 | Lee J E Gen M Rhee K G | 2009 | Computers & Industrial Engineering2009，56，3： | 1 |
| 8 | Temperature effects on the hydraulic behaviour of an unsaturated clay显示文摘 | ROMERO E GENS A LLORET A | 2001 | Geotechnical and Geological Engineering2001，19，34： | 1 |
| 9 | A constitutive model for partially saturated soil显示文摘 | ALONSO E E GENS A JOSA A | 1990 | Geotechnique1990，40，3： | 1 |
| 10 | Modeling the Mechanical Behavior of Expansive Clays显示文摘 | ALONSO E E VAUNAT J GENS A | 1999 | Engineering Geology1999，54，12： | 1 |
| 11 | Aberrant activation of CD8^+ T-cell and CD8^+ T-cell subsets in patients with newly diagnosed IDDM 显示文摘 | Hehmke B Michaelis D Gens E | 1995 | Diabetes1995，44，12： | 1 |
| 12 | A constitutive model for partially saturated soils显示文摘 | ALONSO E E GENS A JOSA A | 1990 | Geotechnique1990，40，3： | 1 |
| 13 | Plasma visfatin level in lean women with POCS:relation to proinflammatory markers and insulin resistance 显示文摘 | Gen R Akbay E Muslu N | 2009 | Gynecol Endocrinol2009，25，4： | 1 |
| 14 | Modelling the mechanical behaviour of expansive clays显示文摘 | ALONSO E E VAUNAT J GENS A | 1999 | Engineering Geology1999，54，： | 1 |
| 15 | Prognosis and 1-year mortality of intensive care unit patients with severe hepatic encephalopathy显示文摘 | Fichet J Mercier E Genée O | | 0，，03： | 1 |
| 16 | A constitutive model for partially saturated soils显示文摘 | ALONSO E E GENS A | 1990 | Geotechnique1990，40，3： | 1 |
| 17 | Parameter andvariance estimation in geotechnical back analysis usingprior information显示文摘 | LEDESMA A GENS A ALONSO E E | 1996 | International Journal forNumerical and Analytical Methods in Geomechanics1996，33，7： | 1 |
| 18 | A constitutive model for partially saturated soils显示文摘 | ALONSO E E GENS A JOSA A | 1990 | Geotechnique1990，40，3： | 1 |
| 19 | Receptor models显示文摘 | Gen E G | 1988 | Environ Sci Technol1988，22，： | 1 |
| 20 | Use of a stimulating catheter for total knee replacement surgery: preliminary results显示文摘 | JACK N T LIEM E B VONH?魻GEN L H | 2005 | British Journal of Anaesthesia2005，95，2： | 1 |
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