|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Aberrant activation of CD8^+ T-cell and CD8^+ T-cell subsets in patients with newly diagnosed IDDM 显示文摘 | Hehmke B Michaelis D Gens E | 1995 | Diabetes1995，44，12： | 1 |
| 3 | Nonlinear fixed charge transportation problem by spanning tree-based genetic algorithm显示文摘 | Jo J B Li Y Z Gen M | 2007 | Computers & Industrial Engineering2007，53，： | 1 |
| 4 | Use of a stimulating catheter for total knee replacement surgery: preliminary results显示文摘 | JACK N T LIEM E B VONH?魻GEN L H | 2005 | British Journal of Anaesthesia2005，95，2： | 1 |
| 5 | Study on the application of DME / diesel blends in a diesel engine显示文摘 | YING W GEN B L WEI Z | 2008 | Fuel Process Technol2008，89，12： | 1 |
| 6 | Evaluation of arterial stiffness in patients with beh?倞et's disease by using noninvasive radiological methods such as intima-media thickness of the carotid,ankle-brachial pressure index,coronaryartery calcium scoring,and their relation to serum fetuin-a levels:a case-control study显示文摘 | Uyar B Solak A GenB | 2015 | Ann Dermatol2015，27，6： | 1 |
| 7 | Distributed generation : semantic hype or the dawn of a new era显示文摘 | PUTI'GEN H B MACGREGOR P R LAMBERT F C | 2003 | IEEE Power and Energy Magazine2003，1，1： | 1 |
| 8 | Synthesis of prenylatedbenzaldehydes and their use in the synthesisof analogues of lico chalcone 显示文摘 | HASSE K M0 GENS L TH0 MAS B KRISTIAN S | 2004 | Eur J MedChem2004，39，11： | 1 |
| 9 | Evolution program for deterministic and stochastic optimizations显示文摘 | Gen M Liu B Ida K | 1996 | European Journal of Operational Research1996，94，3： | 1 |
| 10 | Role of diffusion-weighted MR in differential diagnosis of intracranial cystic lesions显示文摘 | B u kte Y Paksoy Y Gen E | 2005 | Clin Radiol2005，60，3： | 1 |
| 11 | Peptide phage libraries can be an efficient tool for identifying antibody ligands for polyclonal antiseral显示文摘 | Dybwad A Gen B Natvig JB | 1995 | Clin Exp Immunol1995，102，2： | 1 |
| 12 | The Relation Between Prompt and Delayed Emission in Photosynthesis 显示文摘 | Strehler B L Arnold W Gen J | 1951 | Physiol1951，34，： | 1 |
| 13 | Aberrant activation of CD4+ T-cell and CD3+ T-cell subsets in patients with newly diagnosed IDDM 显示文摘 | Hehmke B Miehaelis D Gens E | 1995 | Diabetes1995，44，7： | 1 |
| 14 | Evolution algorithm for optimal capacity expansion显示文摘 | Gen M Liu B | 1997 | Journal of the Operations Research Society of Japan1997，140，1： | 1 |
| 15 | New photochromic foldable intraocular lens: Pre- liminary study of feasibility and biocompatibility 显示文摘 | Werner L Mamalis N Romaniv N Romaniv N Haymore J Hau- gen B | 2006 | J Cataract Refract Surg2006，32，7： | 1 |
| 16 | The effects oftximetazidine on lipid peroxidation in patients with end-stage renal disease 显示文摘 | Ay gen B Celiker H Dogukan A | 2008 | Methods Find EXP ClinPharmacol2008，30，10： | 1 |
| 17 | Aberrant activation of CD4+T-cell and CD8+T-cell subsets in patients with newly diagnosed IDDM显示文摘 | Hehmke B Michaelis D Gens E | 1995 | Diabetes1995，44，7： | 1 |
| 18 | Unique expression of gonadotropin- Ⅰ and-Ⅱ subunits genes in male and female red seabream(Pagrus major) during sexual maturation显示文摘 | GEN K OKUZAWA K SENTHILKUMARAN B | 2000 | Biol Repros2000，63，1： | 1 |
| 19 | Nonlinear fixed charge transporta- tion problem by spanning tree-based genetic algorithm显示文摘 | JO J B LI Y GEN M | 2007 | Computers Industrial Engineering2007，53，： | 1 |
| 20 | Unique expression of gonadotro -pin-I and -II subunit genes in male and fe- male red seabream (Pagrus major) during sexual maturation显示文摘 | GEN K OKUZAWA K SENTHILKUMARAN B | 2000 | Biology of Reproduetivion2000，63，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员