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| 1 | Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease显示文摘AIM To determine the clinical effectiveness of nutritional counseling on reduction of non-alcoholic fatty liver disease(NAFLD) severity, weight loss, metabolic and anthropometric indexes and liver enzymes.METHODS Forty-six adults with NAFLD received a 6-mo clinical and a dietary intervention(based on Mediterranean diet) carried out respectively by a gastroenterologist and a nutritionist with counseling license. The counseling process consisted of monthly meeting(about 45 min each). The effect of the treatment was evaluated monitoring liver enzymes, metabolic parameters, cardiovascular risk indexes, NAFLD severity [assessed by ultrasound(US)] and related indexes. All parameters were assessed at baseline. Biochemistry was also assessed at mid-and end-interventions and US was repeated at end-intervention.RESULTS The percentage of patients with steatosis grade equal or higher than 2 was reduced from 93% to 48% and steatosis regressed in 9 patients(20%). At the end of the treatment the end-point concerning the weight(i.e., a 7% weight reduction or achievement/maintenance of normal weight) was accomplished by 25 out of 46 patients(i.e., 54.3%). As far as the liver enzymes is concerned, all three liver enzymes significantly decrease during the treatment the normalization was particularly evident for the ALT enzyme(altered values reduced from 67% down to 11%). Several parameters, i.e., BMI, waist circumference, waist-to-hip ratio, AST, ALT, GGT, HDL, serum glucose, Tot-Chol/HDL, LDL/HDL, TG/HDL, AIP, HOMA, FLI, Kotronen index, VAI, NAFLD liver fat score and LAP, showed a significant improvement(P < 0.01) between baseline and end-treatment.CONCLUSION Outcomes of this study further strengthen the hypothesis that Med Diet and more active lifestyle can be considered a safe therapeutic approach for reducing risk and severity of NAFLD and related disease states. The proposed approach may be proposed as a valid and recommended approach for improving the clinical profile of NAFLD patients. | Chiara Gelli Mirko Tarocchi Ludovico Abenavoli Laura Di Renzo Andrea Galli Antonino De Lorenzo | 2017 | World Journal of Gastroenterology2017，23，17： | 8 |
| 2 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | Glutamine stimulates translation of uncoupling protein 2mRNA显示文摘 | Hurtaud C Gelly C Chen Z | 2007 | Cell Mol Life Sci2007，64，14： | 1 |
| 4 | Selective constraint on human pre-mRNA splicing by protein structural properties显示文摘 | GELLY J C LIN H Y DE BREVERN A G et ol | 2012 | Genome Biology and Evolution2012，4，9： | 1 |
| 5 | Efficient micro?wave-assisted synthesis of new sulfonylbenzimidazole4, 7 -diones : heterocyclic quinones with potential antitumor activity显示文摘 | Boufatah N Gellis A MaldonadoJ | 2004 | Tetrahedron2004，60，41： | 1 |
| 6 | A Two-Stage CMABased Receiver for Blind Joint Equalization and Multiuser Detection in High Data-Rate DS-CDMA Systems显示文摘 | Giacinto Gelli Luigi Paura Francesco Verde | 2004 | IEEE Trsnsaetions on Wireless Communications2004，3，4： | 1 |
| 7 | Transfusion -associated graft versus host disease in a potient with high - grade B-cell lymphoma显示文摘 | Gelly KJ kerr R Rawlinsons | 2000 | Br J Haematol2000，110，1： | 1 |
| 8 | The impact of postoperative pain on the development of postoperative delirium 显示文摘 | Lynch EP Lazor MA Gellis JE | 1998 | Anesth Analg1998，86，4： | 1 |
| 9 | Corticospinal drive during painful voluntary contractions at constant force output 显示文摘 | Del-Santo F Gelli F Spidalieri R | 2007 | Brain Research2007，1128，： | 1 |
| 10 | Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? 显示文摘 | Arnould L Gelly M Penault-Llorca F | 2006 | Br J Cancer2006，94，2： | 1 |
| 11 | Compression of multispetral images by spectral classification and transform coding显示文摘 | G Gelli G Poggi | 1999 | IEEE Transactions on Image Processing1999，8，4： | 1 |
| 12 | Blind widely linear multiuser detection显示文摘 | GELLI G PAURA L | 2000 | IEEE Commun Lett2000，4，： | 1 |
| 13 | Surface Recovery by Self Shading Projection显示文摘 | DANIELE GELLI DOMENICO VITULANO | 2004 | Signal Process- ing2004，84，： | 1 |
| 14 | Cylostatio narity-based fil tering for narrowband interfer-ence suppression in direct-se- quence spread-spectrum systems显示文摘 | Gelli G Paura L Tulino A M | 1998 | IEEE Journal on Selected Areas in Communications1998，16，9： | 1 |
| 15 | Sleep hygiene practices of good and poor sleepers in the United States: an internet-based study显示文摘 | Gellis LA Lichstein KL | 2009 | Behav Ther2009，40，1： | 1 |
| 16 | An apparatus for grading the visual acuity of infants on the basis of opticokinetic nystagmus显示文摘 | Gorman JJ Cogan DG Gellis SS | 1957 | Pediatrics1957，19，： | 1 |
| 17 | Uncoupling protein 2,in vivo distribution,induction upon oxidative stress,and evidence for translational regulation显示文摘 | PECQUEUR C ALVES-GUERRA M C GELLY C | 2001 | J Biol Chem2001，276，12： | 1 |
| 18 | Glutamine stimulates translation of uncoupling protein 2 mRNA 显示文摘 | Hurtaud C Gelly C Chen Z | 2007 | Cell Mol Life Sci2007，64，14： | 1 |
| 19 | Sleep hygiene practices of good and poor sleepers in the United States: an internet-based study显示文摘 | Gellis LA Lichstein KL | 2009 | Behav Ther2009，40，1： | 1 |
| 20 | Biochemical and Morphologic Effects After Extended Liver Resection in Rats: Preliminary Results显示文摘 | S. Di Domenico G. Santori E. Balbis N. Traverso R. Gentile B. Bocca M. Gelli E. Andorno D. Cottalasso U. Valente | 2010 | Transplantation Proceedings2010，，4： | 1 |
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