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| 1 | Hematopoietic cell transplantation for Crohn’s disease;is it time?显示文摘AIM: To review all studies in the literature that have assessed Hematopoietic cell transplantation (HCT) and Crohn’s disease (CD) with the ultimate aims of determining if this is a viable treatment option for those with CD. A secondary aim was to review the above literature and determine if the studies shed further light on the mechanisms involved in the pathogenesis of CD. METHODS: An extensive Medline search was performed on all articles from 1970 to 2005 using the ; bone marrow transplant, stem cell, hematopoietic cell, Crohn’s disease and inflammatory bowel disease. RESULTS: We identified one case in which a patient developed CD following an allogeneic HCT from a sibling suffering with CD. Evidence for transfer of the genetic predisposition to develop CD was also identified with report of a patient that developed severe CD following an allogeneic HCT. Following HCT it was found that the donor (that had no signs or symptoms of CD) and the recipient had several haplotype mismatches in HLA class Ⅲ genes in the IBD3 locus including a polymorphism of NOD2/CARD15 that has been associated with CD. Thirty three published cases of patients with CD who underwent either autologous or allogeneic HCT were identified. At the time of publication 29 of these 33 patients were considered to be in remission. The median follow-up time was seven years, and twenty months for allogeneic and autologous HCT respectively.For patients who underwent HCT primarily for treatment of their CD there have been no mortalities related to transplant complications. CONCLUSION: Overall these preliminary data suggest that both allogeneic and autologous HCT may be effective in inducing remission in refractory CD. Thissupports the hypothesis that the hematolymphatic cells play a key role in CD and that resetting of the immune system may be a critical approach in the management or cure of CD. | Y Leung M Geddes J Storek R Panaccione PL Beck | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 2 | A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry显示文摘 | Erfan Soliman Sarujan Ranjan Tianyou Xu Carol Gee Aidan Harker Alvaro Barrera John Geddes | 2018 | Bio-Design and Manufacturing2018，1，3： | 3 |
| 3 | Low-frequency ultrasound increases non-viral gene transfer to the mouse lung显示文摘如果在 3035 kHz 的范围,低频率的超声(美国) 增加非病毒的基因转移到老鼠肺,学习的目的是估计。美国极大地在空气 / 织物接口由于大精力损失在肺被稀释。低频率的美国的优点,与高周波的美国相比:(i) 增加了成穴(为在房间膜的短暂毛孔的形成负责) 并且(ii ) 在肺穿入期间减少了精力损失。Cationic 类脂化合物 GL67/plasmid DNA (pDNA ) , polyethylenimine (PEI )/pDNA 和裸体 pDNA 经由 intranasal 灌输被交付,动物然后为 10 min 在 0.07 或 0.1 MPa 暴露于美国(sonoporation ) 。在这些条件下面,美国没提高 GL67 或调停 PEI 的 transfection。然而,它确实由约 4 褶层增加了裸体 pDNA 基因转移。重要地,这当 microbubbles 不在时被完成,它是关键的为通常使用高周波(1 MHz ) sonoporation 但是不能在临床上相关的安装承受 nebulization。肺出血也被估计并且出现以一种剂量依赖者方式与美国压力增加。这样,我们证实了低频率的美国能与裸体 pDNA 提高肺基因转移,这改进比更有效以前报导了 1 个 MHz 美国。 | Stefania Xenariou Hai-Dong Liang Uta Griesenbach Jie Zhu Raymond Farley Lucinda Somerton Charanjit Singh Peter K. Jeffery Ronald K. Scheule Seng H. Cheng Duncan M. Geddes Martin Blomley Eric W. F. W. Alton | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 2 |
| 4 | WHAT DO WE KNOW ABOUT DEMOCRATIZATION AFTER TWENTY YEARS?显示文摘 | Barbara Geddes | 1999 | Annual Review of Political Science1999，，： | 2 |
| 5 | Evidence-based management of primary angle closure glaucoma显示文摘 | Matthew E. Emanuel Richard K. Parrish Steven J. Gedde | 2014 | Current Opinion in Ophthalmology2014，，2： | 2 |
| 6 | Visual function and quality of life among patients with glaucoma 显示文摘 | Parrish RK Gedde SJ Scott IU | 1997 | Arch Ophthalmol1997，115，19： | 1 |
| 7 | Inspiratory muscle training in adults with obstructive pulmonary disease: An update of a systematic review显示文摘 | Geddes EL O'Brien K Reid WD | 2008 | Respir Med2008，102，12： | 1 |
| 8 | Chest compression force of trained and untrained CPR rescuers显示文摘 | GEDDES L A BOLAND M K TALEYARKHAN P R | 2007 | Cardiovasc Eng2007，7，： | 1 |
| 9 | Tunable plasmonic glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids显示文摘 | ASLAN K LAKOWICZ J R GEDDES C D | 2004 | Anal Chim Acta2004，517，12： | 1 |
| 10 | Traumatic axonal injury: practical issues for diagnosis in medicolegal cases显示文摘 | Geddes JF Whitwell HL Graham DI | 2000 | Neuropathol Appl Neurobiol2000，26，2： | 1 |
| 11 | A population-based incidence study of chronic fatigue显示文摘 | Lawrie S Manders D Geddes J | 1997 | Psycholog Med1997，27，2： | 1 |
| 12 | Modified lead oxide-gelatin injection technique for vascular studies显示文摘 | Tang ML Geddes CR Yang DP | 2002 | Clin Anat2002，1，1： | 1 |
| 13 | Europe's border relationships and international migration re- lations显示文摘 | Geddes A | 2005 | Journal of Common Market Studies2005，43，4： | 1 |
| 14 | A high incidence of nucleoside reverse transcriptase inhibitor (NRR1)-in- duced lactic acidosis in HIV-infected patients in a south African context显示文摘 | Geddes R Knight s Moosa MY | 2006 | S Afr Med J2006，96，8： | 1 |
| 15 | The early impact of the United Kingdom Chronic Kidney Disease (CKD)guidelines on the number of new attendances at renal clinics 显示文摘 | Aghaie-Jaladerany H Cowell D Geddes CC | 2007 | Scott Med J2007，52，4： | 1 |
| 16 | Bronchoscopic lung volume reduction for end-stage emphysema:report on the first 98 patients显示文摘 | Wan IY Toma TP Geddes DM | 2006 | Chest2006，129，3： | 1 |
| 17 | Gene therapy progress and prospects:cystic fibrosis显示文摘 | Griesenbach U Geddes DM Alton EW | 2006 | Gene Ther2006，13，14： | 1 |
| 18 | Optimum electrolytic chloriding of silver electrodes 显示文摘 | GEDDES L A BAKER L E MOORE A G | 1969 | Medical and Biological Engineering and Computing1969，7，1： | 1 |
| 19 | The impedance of stainless-steel electrodes显示文摘 | Geddes L A Da Costa C P Wise G | 1971 | Medical & Biological Engineering1971，9，5： | 1 |
| 20 | Perforator flaps: evolution , classification and appfication 显示文摘 | Geddes CR Morris SF Neligan PC | 2003 | Ann Plast Surg2003，50，： | 1 |
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