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	题名	作者	年代	出处	被引量
1	Gene therapeutic approaches to inhibit hepatitis B virus replication显示文摘Acute and chronic hepatitis B virus(HBV) infections remain to present a major global health problem. The infection can be associated with acute symptomatic or asymptomatic hepatitis which can cause chronic inflammation of the liver and over years this can lead to cirrhosis and the development of hepatocellularcarcinomas. Currently available therapeutics for chronically infected individuals aim at reducing viral replication and to slow down or stop the progression of the disease. Therefore, novel treatment options are needed to efficiently combat and eradicate this disease. Here we provide a state of the art overview of gene therapeutic approaches to inhibit HBV replication. We discuss non-viral and viral approaches which were explored to deliver therapeutic nucleic acids aiming at reducing HBV replication. Types of delivered therapeutic nucleic acids which were studied since many years include antisense oligodeoxynucleotides and antisense RNA, ribozymes and DNAzymes, RNA interference, and external guide sequences. More recently designer nucleases gained increased attention and were exploited to destroy the HBV genome. In addition we mention other strategies to reduce HBV replication based on delivery of DNA encoding dominant negative mutants and DNA vaccination. In combination with available cell culture and animal models for HBV infection, in vitro and in vivo studies can be performed to test efficacy of gene therapeutic approaches. Recent progress but also challenges will be specified and future perspectives will be discussed. This is an exciting time to explore such approaches because recent successes of gene therapeutic strategies in the clinic to treat genetic diseases raise hope to find alternative treatment options for patients chronically infected with HBV.	Maren Gebbing Thorsten Bergmann Eric Schulz Anja Ehrhardt	2015	World Journal of Hepatology2015，7，2：	2
2	Mininal alteration in the ratio of circulatory fetal DNA to fetal corticotropin--releasing hormone mRNA level in preeelampsia 显示文摘	Zhong XY Holzqreve W Geb Hardts	2006	Fetal Diagn Therapy2006，21，3：	1
3	New therapies for ovarian cancer: cytotoxics and molecularly targeted agents显示文摘	Dinh P Harnett P Piccart Geb hart MJ	2008	Crit Rev oncol Hematol2008，67，2：	1
4	Aptamer-basedbiosensorsforlabel-freevoltammetricdetectionoflysozyme显示文摘	ChengAK GeB YuH-Z	2007	Analyticalchemistry2007，79，：	1
5	Iodine-131 treatment of hyperthyroidism:significance of effective halflife measurements显示文摘	Berg GEB Annika MK Holmberg EC et a1	1996	J Nucl Med1996，37，2：	1
6	13C Labeling kinetics of sucrose in glumes indicates significant refixation of respiration CO2 in the wheat ear显示文摘	Gebbing T Schnyder H	2001	Aust J Plant Phyiol2001，28，：	1
7	Dynamic external fixation for pilon fractures of the interphalangeal joints显示文摘	Hynes Mc Giddins GEB	2001	Hand Surg2001，26，2：	1
8	Pre-anthesis reserve utilization for protein and carbohydrate synthesis in grains of wheat显示文摘	Gebbing T Schnyder H	1999	Plant Physiology1999，121，3：	1
9	The Impact of Leverage on Finn Investment: Canadian Evidence 显示文摘	Varouj A Aivaziana Ying Geb liaping Qiu	2005	Journal of Corporate Finance2005，11，12：	1
10	Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells 显示文摘	Xua YF Geb RL Dua J	2009	Cancer Lett2009，284，2：	1
11	查看详情显示文摘	Klatt G R. Gebs		0，，01：	1
12	Iodine-131 treatment of hyperthyroidism:Significance of effect half-life measurements显示文摘	Berg GEB Michamek AMK Holmberg ECV	1996	J Nucl Med1996，37，：	1
13	Comparison between a Single Dose of Goserelin (Depot) and Multiple Daily DosIVF Treatment: A Clinical Endocrinological Study of the Ovarian Response 显示文摘	Selmo Geb er Liana Sales	2002	Journal of Assisted Reproduction and Genetic2002，19，7：	1
14	Selenium distribution in the local environment of selected villages of the Keshan disease belt,Zhangjiakou District,Hebei Province,People’s Republic of China显示文摘	JOHNSON C C GEB X GREENA K A	2000	Applied Geochemistry2000，15，：	1
15	Optimization of Cry3A Yields in Bacillus thuringiensis by Use of Sporulation-dependent Promoters in Combination with the STAB-SD mRNA Sequence显示文摘	PARK H W GEB BAUER LS	1998	Appl Environ Microbiol1998，64，：	1
16	Pre-anthesis reserve utilization for protein and carbohydrate synthesis in grains of wheat显示文摘	Gebbing T Schnyder H	1999	Plant Physiology1999，121，3：	1
17	Pre-anthesis reserve utilization for protein and carbohydrate synthesis in grains of wheat显示文摘	Gebbing T Schnyder H		0，，：	1
18	PositiveidentificationofCA125pancancerbiomarkerfromserumspecimensofcancerpatients显示文摘	LeeG GeB HuangTK etal	2010	CancerBiomarker2010，6，2：	1
19	Rhizodeposition shapesrhizosphere microbial community structure in organic soil显示文摘	Paterson E Gebbing T Abel C	2007	New Phytologist2007，173，3：	1
20	Pre-anthesis reserve utilization for protein and carbohydrate synthesis in grains of wheat 显示文摘	Gebbing T Schnyder H	1999	Plant Physiology1999，121，：	1

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