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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | 成年大鼠睾丸经EDs处理后再生睾丸间质细胞基因图谱的改变显示文摘成年睾丸间质细胞(ALC)是睾丸中产生雄激素的唯一内分泌细胞,只占有睾丸细胞的1%-5%。大鼠睾丸中的睾丸间质细胞被EDs去除后能够再生。本研究中,我们主要研究了大鼠睾丸经EDS处理后睾丸间质细胞再生及基因的变化图谱。EDS处理后7、21、35、90天后分析血清中睾酮、睾丸基因图谱和一些类固醇生成相关的蛋白变化情况。EDS处理后第7天睾丸中睾酮水平几乎检测不到,然后开始恢复。处理后7天,81个基因下调2倍或者更多,其中48个基因检测不到,包括类固醇合成通路中的蛋白Star、Scarbl、Cypllal、Cypl7al、Hsd3bl、CyplblICyp2al。这些基因在21天开始表达增多,到90天已经完全恢复到正常水平。89个基因上调2倍或者更高,nPkib。这些上调的基因到90天恢复正常;其中Cyp2al直到35天才开始恢复,表明这个基因只在成年睾丸间质细胞中表达,不在前体细胞中表达。qPCR,Westernblot、半定量免疫组织染色检测了随机抽取的基因和蛋白确认其变化情况。 | Yu-Fei Zhang Kai-Ming Yuan Yong Liang Yan-Hui Chu Qing-Quan Lian Yu-Fei Ge Wei Zhen Chantal M Sottas Zhi-Jian Su Ren-Shan Ge | 2015 | Asian Journal of Andrology2015，17，2： | 5 |
| 3 | 体位性低血压的危险因素:老年男女存在差异显示文摘体位性低血压(orthostatic hypotension,OH)一般发生在站立后调节血压水平的机制发生变化以后。目前尚不清楚不同性别间OH的发生率和危险因素有何不同。本文旨在调查老年人OH患病率和危险因素的性别差异。方法:纳入来自委内瑞拉马拉开波老龄化研究的882名参与者。从仰卧位到站立位3 min后,收缩压持续下降≥20和(或)舒张压持续下降≥10 mm Hg(1 mm Hg=0.133 kPa)定义为OH。考虑到性别的交互作用和性别分层,研究者采用多因素Logistic回归模型评估男、女OH危险因素的相关性。 | Méndez AS Melgarejo JD Mena LJ Chávez CA González AC Boggia J Terwilliger JD Lee JH Maestre GE 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 4 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 5 | Multislice spiral computed tomography imaging in evaluating hemophilic arthropathy显示文摘Background:Certain hemophilia patients are unable to cooperate with or afford magnetic resonance imaging(MRI)examinations.The purpose of our study was to explore the value of multislice spiral computed tomography(MSCT)in evaluating hemophilic arthropathy(HA).Methods:Thirty-eight patients with 73 joints of HA were consecutively selected from January 2016 to May 2018 for this prospective study.All 73 joints were examined by X-ray,CT,and MRI within 2 days.The MRI scores of the joints were determined by the International Prophylaxis Study Group(IPSG)standard.The CT findings were quantified according to the IPSG standard,except for cartilage injury,which was quantified by joint space narrowing using the X-ray Pettersson score.The CT and MRI scores were compared by the paired Wilcoxon signed-rank test.The correlations between the CT score of joint space narrowing and MRI score of cartilage injury and the total CT and MRI scores were analyzed by Spearman rank correlation.The kappa test was used to compare the consistency of CT and MRI scores.Results:MRI was superior to CT based on the scores for small amount of effusion(P<0.05),synovial hypertrophy and hemosiderin deposition in the mild groups(P<0.05).The CT and MRI scores were not significantly different for moderate and massive effusion,synovial hypertrophy,and hemosiderin deposition in the moderate and severe groups,bone erosion or cystic changes(P>0.05),and there was a high degree of consistency between the two scores(kappa>0.81).The consistency between the Pettersson scores of joint space narrowing on CT and the IPSG scores of cartilage injury on MRI was high(kappa=0.774,P<0.05).Conclusion:The image scores of MSCT are generally consistent with MRI except for mild synovitis,which can be used as an alternative for the evaluation of HA. | Yu-Xia Zhang M ei-Xia Li Shu-Fang Wei Lu Zhang Tian-Ming Cheng Ying-Hui Ge | 2020 | Chinese Medical Journal2020，，14： | 2 |
| 6 | Tracking control of a piezoceramic actuator 显示文摘 | GE Ping JOUANEH M | 1996 | IEEE Trans on Control Systems Technology1996，4，3： | 1 |
| 7 | PANDA software and its preliminary result for positioning and orbit determination 显示文摘 | Liu J N and Ge M R | 2003 | Wuhan University Journal of Natural Science2003，8，2： | 1 |
| 8 | Assay of cyclooxygenase-1 and 2 in human monocytes 显示文摘 | Demasi M Canghey GE James MJ | 2000 | Inflamm Res2000，49，12： | 1 |
| 9 | Artificial synthesis of interspecific chimeras between tuber mustard (Brassica juncea ) and cabbage (Brassica oleracea) and cytological analysis 显示文摘 | Chen L P Ge Y M Zhu X Y | 2006 | Plant Cell Rep2006，25，： | 1 |
| 10 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H Ge N Catron D Buchanan M E | 2001 | Nature2001，410，： | 1 |
| 11 | Dynamic fixation for distal radius fractures显示文摘 | Dienst M Wozasek GE Deligson D | 1997 | Clin Orthop1997，338，： | 1 |
| 12 | Computer aided geometric design of two param- eters free form motion显示文摘 | Ge Q J Sirchia M | 1999 | Journal of Mechanical Design( ASME)1999，121，4： | 1 |
| 13 | Neurodegenerationin the central nervous system of apoE-deficient mice显示文摘 | Masliah E Mallory M Ge N | 1995 | Exp Neurol1995，136，： | 1 |
| 14 | DNA methyltransferase 1 -associ ated protein ( DMAP1 ) is a co-repressor that stimulates DNA methy lation globally and locally at sites of double strand bread repair显示文摘 | Lee GE Kim JH Taylor M | 2010 | Biol Chen2010，285，37： | 1 |
| 15 | Surface acidic and redox properties of V-Ag-Ni-O catalysts for the selective oxidation of toluene to benzaldehyde 显示文摘 | XUE M GE J ZHANG H | 2007 | Appl Catal A: Gen2007，330，12： | 1 |
| 16 | The regular and chaotic motion of a symmetric heavy gyro- scope with harmonic excitation显示文摘 | Ge Z M Chen H K Chen H H | 1996 | J Sound Vibr1996，198，2： | 1 |
| 17 | Tracking control of a piezoceramic ac- tuator 显示文摘 | Ge P Jouaneh M | 1996 | IEEE Transactions on Control Systems Technol- ogy1996，4，3： | 1 |
| 18 | Chaos synchronizat-ion and parameter identification of three time scales brushless DC motor system,Chaos显示文摘 | Z M Ge J W Cheng | 2005 | Solitons and Fractals2005，24，： | 1 |
| 19 | Reproductive biology and genetic diversity of a cryptoviviparous mangrove Aegiceras corniculatum(Myrsinaceae) using allozyme and intersimple sequence repeat(ISSR)analysis显示文摘 | GE X J SUN M | 1999 | Mol Ecol1999，8，12： | 1 |
| 20 | Phospholipase A2 isozymes in pregnancy and parturition显示文摘 | Lappas M Rice GE | 2004 | Prostaglandins Leukot Essent Fatty Acids2004，70，2： | 1 |
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