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| 1 | Wound-Induced Shoot-to-Root Relocation of JA-Ile Precursors Coordinates Arabidopsis Growth显示文摘Multicellular organisms rely on the movement of signaling molecules across cells,tissues,and organs to communicate among distal sites.In plants,localized leaf damage activates jasmonic acid(JA)-dependent transcriptional reprogramming in both harmed and unharmed tissues.Although it has been indicated that JA species can translocate from damaged into distal sites,the identity of the mobile compound(s),the tissues through which they translocate,and the effect of their relocation remain unknown.Here,we found that following shoot wounding,the relocation of endogenous jasmonates through the phloem is essential to initiate JA signaling and stunt growth in unharmed roots of Arabidopsis thaliana.By employing grafting experiments and hormone profiling,we uncovered that the hormone precursor cis-12-oxo-phytodienoic acid(OPDA)and its derivatives,but not the bioactive JA-Ile conjugate,translocate from wounded shoots into undamaged roots.Upon root relocation,the mobile precursors cooperatively regulated JA responses through their conversion into JA-Ile and JA signaling activation.Collectively,our findings demonstrate the existence of long-distance translocation of endogenous OPDA and its derivatives,which serve as mobile molecules to coordinate shoot-to-root responses,and highlight the importance of a controlled redistribution of hormone precursors among organs during plant stress acclimation. | Adina Schulze Marlene Zimmer Stefan Mielke Hagen Stellmach Charles WMelnyk Bettina Hause Debora Gasperini | 2019 | Molecular Plant2019，12，10： | 7 |
| 2 | Rhabdomyolysis after midazolam administration in a cirrhotic patient treated with atorvastatin显示文摘The administration of statins in patients with liver disease is not an absolute contraindication. Hepatotoxicity is a rare and often dose-related event and in the literature there are only a few described cases of fatal rhab-domyolysis in patients with chronic liver disease after statin administration. During treatment with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors,the factors responsible for myopathy may either be related to the patient,or due to interactions with other medications that are metabolic substrates of the same isozymes and therefore able to increase blood statin concentration. The most important side effects consist of increased transaminase levels,abdominal pain or muscle weakness,increased serum levels of creatine kinase and rhabdomyolysis. In this article we report a case of fatal rhabdomyolysis with acute renal failure after gastric endoscopy,where midazolam was used as a sedation agent in a patient with chronic liver disease treated with a high dose of atorvastatin. Therefore,we suggest paying particular attention to the potential risks of associating atorvastatin and midazolam in patients with chronic liver disease who need to undergo gastric endoscopy. | Antonietta Gigante Gianluca Di Lazzaro Giraldi Maria Ludovica Gasperini Biagio Barbano Marta Liberatori Liborio Sardo Francesca Di Mario Antonella Giorgi Filippo Rossi-Fanelli Antonio Amoroso | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 6 |
| 3 | Adult myelination: wrapping up neuronal plasticity显示文摘In this review, we outline the major neural plasticity mechanisms that have been identified in the adult central nervous system(CNS), and offer a perspective on how they regulate CNS function. In particular we examine how myelin plasticity can operate alongside neurogenesis and synaptic plasticity to influence information processing and transfer in the mature CNS. | Megan O’Rourke Robert Gasperini Kaylene M.Young | 2014 | Neural Regeneration Research2014，9，13： | 6 |
| 4 | Gene expression and produc- tion of the monokine induced by IFN-gamma (MIG), IFN inducible T cell alpha chemoattractant (I-TAC), and IFN-gammainducible pro- tein-10 (IP-10) chemokines by human neutrophils 显示文摘 | Gasperini S Marchi M Calzetti F | 1999 | J Immunol1999，162，： | 1 |
| 5 | The neutrophil as a cellular source of cheraokines 显示文摘 | SCAPINI P LAPINET VERA J A GASPERINI S | 2000 | Immunological Reviews2000，177，： | 1 |
| 6 | Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees显示文摘 | Franchini L Serretti A Gasperini M | 1998 | J Psychiatr Res1998，32，5： | 1 |
| 7 | Testicular metastases: a poor prognostic factor in pa- tients with advanced prostate cancer 显示文摘 | KORKES F GASPERINI R KORKES K L | 2009 | World J Urol2009，27，： | 1 |
| 8 | Cytokines expression in SLE nephritis 显示文摘 | Gigante A Gasperini ML Afeltra A | 2011 | Eur Rev Med PharmacolSci2011，15，1： | 1 |
| 9 | Defining seismogenic sources from historical earthquake felt reports显示文摘 | Gasperini P Bernardini F Valensise G | | 0，，1： | 1 |
| 10 | Interleukin 10 (IL- 10) upregulates IL-1 receptor antagonist production from lipopolysaccharide stimulated human polymorphonuclear leukocytes by delaying mRNA degradation 显示文摘 | Cassatella MA Meda L Gasperini S | 1994 | J Exp Med1994，179，： | 1 |
| 11 | Role of NINJA in root jasmonate signaling显示文摘 | Acosta IF Gasperini D Chetelat A | 2013 | Proc Natl Acad Sci USA2013，110，15： | 1 |
| 12 | Microscopic assessments of diease burden by MRI in multipl sclerosis: relationship to clinical parameters显示文摘 | Gasperini C Horsfield MA Thorpe JW | 1996 | J Magn Reson Imaging1996，6，4： | 1 |
| 13 | Cytokines expression in SLE nephritis 显示文摘 | Gigante A Gasperini ML Afeltra A | 2011 | Eur Rev Med Pharmacol Sei2011，15，1： | 1 |
| 14 | Inter and intra-individual variability of sperm morphology after selection with three different techniques:layering,swimup from pellet and percoll显示文摘 | Canale D Giorgi P M Gasperini M | 1994 | Journal of Endocrinological Investigation1994，17，9： | 1 |
| 15 | The attenuation of seismic intensity in Italy : A Bilinear shape indicates the dominance of deep phases at epicentral distances lon- ger than 45 km显示文摘 | Paolo Gasperini | 2001 | Bulletin of Seismological Society of America2001，91，4： | 1 |
| 16 | Effect of initial texture on deformation mechanisms and texture evolutions of Zr α polycrystals deformed by channel-die compression tests显示文摘 | Francillette H Bacroix B Gasperini M | 1997 | Materials Science and Engineering A1997，，： | 1 |
| 17 | Phosphorus acids as highly efficient promotes for the palladium-phenanthroline catalyzed carbonylation of nitrobenzene to methyl phenylcarbamate 显示文摘 | Ragaini F Gasperini M Cenini S | 2004 | Advanced Synthesis & Catalysis2004，346，1： | 1 |
| 18 | Interleukin-12 production by human polymorphonuclear leukocytes显示文摘 | Cassatella MA Meda L Gasperini S | 1995 | Eur J Immunol1995，25，1： | 1 |
| 19 | Development roles for Homer:more than just a pretty scaffold显示文摘 | FOA L GASPERINI R | 2009 | J Neurochem2009，108，1： | 1 |
| 20 | The neu- trophil as acellular source of chemokines显示文摘 | Scapini P Lapinet-Vera JA Gasperini S | 2000 | Immunol Rev2000，177，： | 1 |
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