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| 1 | Metabolic surgery and intestinal gene expression:Digestive tract and diabetes evolution considerations显示文摘AIM: To investigate the effects of bariatric surgery on metabolic parameters, incretin hormone secretion, and duodenal and ileal mucosal gene expression.METHODS: Nine patients with type 2 diabetes mellitus(T2DM), chronic serum hyperglycemia for more than2 years, and a body mass index(BMI) of 30-35 kg/m2 underwent metabolic surgery sleeve gastrectomy with transit bipartition between May 2011 and December2011. Blood samples were collected pre and 3, 6 and12 mo postsurgery. Duodenal and ileal mucosa samples were collected pre- and 3 mo postsurgery. Pre- and postoperative blood samples were collected in the fasting state before ingestion of a standard meal(520kcal) and again 30, 60, 90, and 120 min after the mealto determine hemoglobin A1c(HbA1c) levels and the lipid profile, which consisted of triglyceride and total cholesterol levels. Intestinal gene expression of p53 and transforming growth factor(TGF)-β was analyzed using quantitative reverse-transcription PCR. Gastric inhibitory polypeptide(GIP) and glucagon-like peptide-1(GLP-1)were quantified using the enzyme-linked immunoassay method and analyzed pre- and postoperatively.Student's t test or repeated measurements analysis of variance with Bonferroni corrections were performed as appropriate.RESULTS: BMI values decreased by 15.7% within the initial 3 mo after surgery(31.29 ± 0.73 vs 26.398± 0.68, P < 0.05) and then stabilized at 22% at 6mo postoperative, resulting in similar values 12 mo postoperatively(20-25 kg/m2). All of the patients experienced improved T2 DM, with 7 patients(78%)achieving complete remission(HbA1c < 6.5%), and 2patients(22%) achieving improved diabetes(HbA1c< 7.0% with or without the use of oral hypoglycemic agents). At 3 mo postoperatively, fasting plasma glucose had also decreased(59%)(269.55 ±18.24 mg/dL vs 100.77 ± 3.13 mg/dL, P < 0.05)with no further significant changes at 6 or 12 mo postoperatively. In the first month postoperatively,there was a complete withdrawal of hypoglycemic medications in all patients, who were taking at least2 hypoglycemic drugs preoperatively. GLP-1 levels significantly increased after surgery(149.96 ± 31.25 vs220.23 ± 27.55)(P < 0.05), while GIP levels decreased but not significantly. p53 gene expression significantly increased in the duodenal mucosa(P < 0.05, 2.06 fold)whereas the tumor growth factor-β gene expression significantly increased(P < 0.05, 2.52 fold) in the ileal mucosa after surgery.CONCLUSION: Metabolic surgery ameliorated diabetes in all of the patients, accompanied by increased antiproliferative intestinal gene expression in non-excluded segments of the intestine. | Marcos Ricardo da Silva Rodrigues Marco Aurelio Santo Giovani Marino Favero Elaine Cristina Vieira Roberto Ferreira Artoni Viviane Nogaroto Egberto Gaspar de Moura Patricia Lisboa Fabio Quirillo Milleo | 2015 | World Journal of Gastroenterology2015，21，22： | 2 |
| 2 | Current status and clinical applications of cardiac multidetector computed tomography显示文摘 | Halon DA Rubinshtein R Gaspar T | 2008 | Cardiology2008，109，2： | 1 |
| 3 | Role of the C677T polymorphim at the mthfr gene on risk to nonsyndromic cleft lip with/without cleft palate:results from a case-control study in brazil显示文摘 | Gaspar DA Pavanello RC Zatz M | 1999 | Am J Med Genet1999，87，2： | 1 |
| 4 | Evidence that BCL3 plays a role in the etiology of nonsyndromic oral cleft in Brazilian families显示文摘 | Matioli SR Pavanello RC | 2002 | Genetic Epidemilolgy2002，23，4： | 1 |
| 5 | Diagnosis of coronary in-stent restenosis with multidetector row spiral computed tomography显示文摘 | Gaspar T Halon DA Lewis BS | 2005 | J Am coll Cardiol2005，46，8： | 1 |
| 6 | Evidence that BCL3 plays a role in the etiology of nonsyndromic oral clefts in Brazilian families显示文摘 | Gaspar DA Matioli SR Pavanello RC | 2002 | Genet Epidemiol2002，23，4： | 1 |
| 7 | Transforming growth factor-a and nonsyndromic cleft lip with or without palate in Brazilian patients:results of a large case-control study 显示文摘 | passos-Bueno MR Gaspar DA Kamiya T | 2004 | Cleft Palate Craniofac J2004，41，： | 1 |
| 8 | Role of the C677T polymorphism at the MTHFR gene on risk to nonsyndromic cleft lip with/without cleft palate: results from a case-control study in Brazil显示文摘 | Gaspar DA Pavanello RC Zatz M | 1999 | Am J Med Genet1999，87，2： | 1 |
| 9 | Radiation therapy in the unreseetal cavernous hemangioma of the liver显示文摘 | Gaspar C Mascarenhas F da Costa MS | 1993 | Radither Onco11993，29，1： | 1 |
| 10 | Usefulness of 64-slice multidetector computed tomography in diagnostic triage of patients with chest pain and negative or nondiagnostic exercise treadmill test rest result显示文摘 | Rubinshtein R Halon DA Gaspar T | 2007 | The American Journal of Cardiology2007，99，7： | 1 |
| 11 | Diagnosis of coronary in-stent restenosis with multidetector row spiral computed tomography显示文摘 | Gaspar T Halon DA Lewis BS | 2005 | J Am Coll Cardiol2005，46，： | 1 |
| 12 | Usefulness of 64-slice cardiac computed tomographic angiography for diagnosing acute coronary syndromes and predicting clinical outcome in emergency department patients with chest pain of uncertain origin 显示文摘 | Rubinshtein R Halon DA Gaspar T | 2007 | Circulation2007，115，13： | 1 |
| 13 | Automatic assessment of coronary artery calcium score from contrast- enhanced 256-row coronary computed tomography angiography 显示文摘 | Rubinshtein R Halon DA Gaspar T | 2014 | Am J Cardiol2014，113，： | 1 |
| 14 | Usefulness of 64 -slice multidetector computed tomography in diagnostic triage of patients with chest pain and negative or nondiagnostic exercise treadmill test result显示文摘 | Rubinshtein R Halon DA Gaspar T | 2007 | Am J Cardiol2007，99，7： | 1 |
| 15 | Diagnosis of coronary instent restenosis with mutidetector TOW spiral computed tomography 显示文摘 | Gaspar T Halon DA Lewis BS | 2005 | J Am Coil Cardio12005，46，8： | 1 |
| 16 | Transforming growth factor-a and nonsyndromic cleft lip with or without palate in Brazilian patients:results of a large case-control study显示文摘 | Passos-Bueno MR Gaspar DA Kamiya T | 2004 | Cleft Palate Craniofac J2004，41，： | 1 |
| 17 | Advantages of multidetector eompuled tomography in the evaluation of palients with chest paim显示文摘 | Gaspar T Haton DA Pcled N | 2006 | Cowull Arler Dis2006，17，： | 1 |
| 18 | Diagnosis of coronary instent restenosis with multidetector row spiral computed tomography显示文摘 | Gaspar T H alon DA Lewis BS | 2005 | J Am Coll Cardiol2005，46，8： | 1 |
| 19 | Laparo- scopie treatment of endometriosis 显示文摘 | Meuleman C Tomassetti C Gaspar Da Vitoria Magro M | 2013 | Minerva Gineeol2013，65，2： | 1 |
| 20 | Elevated CO2 increases photosynthesis, biomass and productivity, and modifies gene expression in sugarcane显示文摘 | De Souza A P Gaspar M Da Silva E A | 2008 | Plant Cell & Environment2008，31，8： | 1 |
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