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| 1 | Spontaneous rupture of hepatic hemangiomas:A review of the literature显示文摘Hepatic hemangiomas are congenital vascular malformations,considered the most common benign mesenchymal hepatic tumors,composed of masses of blood vessels that are atypical or irregular in arrangement and size. Hepatic hemangiomas can be divided into two major groups:capillary hemangiomas and cavernous hemangiomas These tumors most frequently affect females (80%) and adults in their fourth and fifth decades of life. Most cases are asymptomatic although a few patients may present with a wide variety of clinical symptoms,with spontaneous or traumatic rupture being the most severe complication. In cases of spontaneous rupture,clinical manifestations consist of sudden abdominal pain,and anemia secondary to ahaemoperitoneum. Disseminated intravascular coagulopathy can also occur. Haemodynamic instability and signs of hypovolemic shock appear in about one third of cases. As the size of the hemangioma increases,so does the chance of rupture. Imaging studies used in the diagnosis of hepatic hemangiomas include ultrasonography,dynamic contrast-enchanced computed tomography scanning,magnetic resonance imaging,hepatic arteriography,digital subtraction angiography,and nuclear medicine studies. In most cases hepatic hemangiomas are asymptomatic and should be followed up by means of periodic radiological examination. Sur gery should be restricted to specific situations. Absolute indications for surgery are spontaneous or trau m atic rupture with hemoperitoneum,intratumoral blee ding and consumptive coagulopathy (Kassabach-Merrit syndrome). In a patient presenting with acute abdo minal pain due to unknown abdominal disease,sponta neous rupture of a hepatic tumor such as a hemangio ma should be considered as a rare differential diagnosis. | Marcelo AF Ribeiro Francine Papaiordanou Juliana M Gonalves Eleazar Chaib | 2010 | World Journal of Hepatology2010，2，12： | 12 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Screening for Gastric Cancer and Surveillance of Premalignant Lesions: a Systematic Review of Cost‐Effectiveness Studies显示文摘 | Miguel Areia Rita Carvalho Ana Teresa Cadime Francisco Rocha Gon?alves Mário Dinis‐Ribeiro | 2013 | Helicobacter2013，，5： | 3 |
| 4 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 5 | Effects of a Saccharomyces cerevisiae yeast on ruminal fermentation and fibre degradation of maize silages in cows显示文摘 | Guedes C M Gon alves D Rodrigues M A M | 2008 | Anim Feed Sci Tech2008，145，1： | 1 |
| 6 | Effect of a wave-band shift on chlorophyll retrieval from MERIS imagery ofinland and coastal waters显示文摘 | Gons H J Rijkeboer M Ruddick K G | 2005 | Journal of Plankton Re-search2005，27，1： | 1 |
| 7 | Optimizing grain yields reduces CH4 emissions from rice paddy fields显示文摘 | Denier Van Der Gon H A C Kropff M J Van Breemen N | 2002 | Proceedings of the National Academy of Sciences of the United States of America2002，99，12： | 1 |
| 8 | Detection of ethanol gas concentration by fuel cell sensors fabricated using a solid polymer electrolyte 显示文摘 | Kim K C Cho S M Choi H Gon | 2000 | Sensors and Actuators B2000，67，1： | 1 |
| 9 | Identification and characterization of MtMTP1,a Zn transporter of CDF family,in the Medicago truncatula显示文摘 | CHEN M L SHEN X Y LI D F MA L GON J L WANG T | 2009 | Plant Physiology and Biochemistry2009，47，： | 1 |
| 10 | Quantitative study of caspase-3 activity in semen and after swim-up preparation in relation to sperm quality显示文摘 | Almeida C Cardoso MF Sousa M Viana P Gon(c)alves A Silva J | 2005 | Hum Reprod2005，20，5： | 1 |
| 11 | The Camino intracranial pressure device in clin- ical practice 显示文摘 | Gelabert - Gon ~ alez M Ginesta - Galan V Sernamito Gar ~I a R | 2006 | Acta Neurochirurg2006，4，148： | 1 |
| 12 | Optical remote sensing of chlorophyll-a in case 2 waters by use of an adaptive two-band algorithm with optimal error properties显示文摘 | Ruddick K G Gons H J Rijkeboer M | 2001 | Applied Optics2001，40，21： | 1 |
| 13 | Early diagnostic and endoscopic dilatation for the treatment of acquired upper airway stenosis after intubation in children显示文摘 | MAKSOUD FILHO J G GONALVES M E CARDOSO S R | 2008 | J Pediatr Surg2008，43，7： | 1 |
| 14 | Maternal-fetal transfer of thy- roxine in congenital hypothyroidism due to a total organifieation defect or thyroid agenesis显示文摘 | Vulsma T Gons M H de Vijlder JJ | 1989 | N Engl J Med1989，321，1： | 1 |
| 15 | Cross-sectional and longitu- dinal associations between serum uric acid and metabolic syndrome 显示文摘 | Gon$alves JP Oliveira A Severo M | 2012 | Endocrine2012，41，3： | 1 |
| 16 | Diamondoid and biomarker characterization of oils from the Llanos Orientales Basin, Colombia 显示文摘 | SPRINGER M V GARCIA D E GON(ALVES F T T | 2010 | Organic Geochemistry2010，41，9： | 1 |
| 17 | On the spectral radius of trees显示文摘 | GON J M TAN S W | 2001 | Linear Algebra Appl2001，329，： | 1 |
| 18 | Emissions of persistent organic pollutants and eight candidate POPs from UNECE-Europe in 2000,2010 and2020 and the emission reduction resulting from the implementation of the UNECE POP protocol显示文摘 | Denier Van Der Gon H Van Het Bolscher M Visschedijk A | 2007 | Atmos Environ2007，41，40： | 1 |
| 19 | Effects of rabeprazole or famotidine during cardiac surgery on perioperative gastric and esophageal pH readings 显示文摘 | Gon S Irie Y Takahashi M | 2006 | Jpn J Thorac Cardiovase Surg2006，54，7： | 1 |
| 20 | Activation of the fly ash pozzolanic reaction by hydrothermal conditions显示文摘 | GON~I S GUERRERO A LUXàN M P | 2003 | Cement and Concrete Research2003，33，9： | 1 |
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