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	题名	作者	年代	出处	被引量
1	T-cell ageing in end-stage renal disease patients:Assessment and clinical relevance显示文摘End-stage renal disease(ESRD) patients have a defective T-cell-mediated immune system which is related to excessive premature ageing of the T-cell compartment.This is likely to be caused by the uremia-associated pro-inflammatory milieu,created by loss of renal function.Therefore,ESRD patients are highly susceptible for infections,have an increased risk for virus-associated cancers,respond poorly to vaccination and have an increased risk for atherosclerotic diseases.Three ageing parameters can be used to assess an immunological T-cell age.First,thymic output can be determined by assessing the T-cell receptor excision circlescontent together with CD31 expression within the naive T cells.Second,the telomere length of T cells and third the T-cell differentiation status are also indicators of T-cell ageing.Analyses based on these parameters in ESRD patients revealed that the immunological T-cell age is increased by on average 20 years compared to the chronological age.After kidney transplantation(KTx) the aged T-cell phenotype persists although the pro-inflammatory milieu is diminished.This might be explained by epigenetic modifications at hematopoietic stem cells level.Assessment of an immunological T-cell age could be an important tool to identify KTx recipients who are at risk for allograft rejection or to prevent over-immunosuppression.	Ruud WJ Meijers Michiel GH Betjes Carla C Baan Nicolle HR Litjens	2014	World Journal of Nephrology2014，3，4：	2
2	Genetic markers: progress and potential for cardiovascular disease显示文摘	Gibbons GH Liew C C Goodarzi M O	2004	Grculation2004，109，251：	1
3	Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle显示文摘	D'ANGELO J G BORD N C POSNER GH	2009	J Antimicrob Chemother2009，63，1：	1
4	Enteroviral protease 2A Cleaves dystrophin:evidence of cytosketal disruption in an acquired cardiomyopathy显示文摘	Badorff C Lee GH Lamphear BJ	1999	Nat Med1999，5，：	1
5	Salivary concentrations of urea re-leased from a chewing gum containing urea and howthese affect the urea content of gel -stabilized plaquesand their pH after exposure to sucrose 显示文摘	Dawes C Dibdin GH	2001	Caries Res2001，35，5：	1
6	Cataract surgery and postoperative endophthalmitis显示文摘	Stefan C Anghel GH Tebeanu E		0，，03：	1
7	DCE-MRI of the liv- er: effect of linear and nonlinear conversions on hepatic perfusion quantification and reproducibility显示文摘	Aronhime S Calcagno C Jajamovieh GH	2014	J Magn Reson Imaging2014，40，：	1
8	Implications of transdisciplinarity for sustainability research 显示文摘	Hadorna GH Bradley D Pohlc C Ristd S Wiesmannd U	2009	Ecologiealeconomics2009，，60：	1
9	Adolescent aggression: models of resiliency显示文摘	HoUister-Wagner GH Foshee VA Jackson C	2001	J Appl Social Psychoi2001，31，3：	1
10	A mathematical model of theinfluence of salivary urea on the pH of fasted dentalplaque and on the changes occurring during a cariogenicchallenge显示文摘	Dibdin GH Dawes C	1998	Caries Res1998，32，1：	1
11	A new group of chromatinassociated proteins with a high content of acidic and basic amino acids显示文摘	Goodwin GH Sanders C Johns EW		0，，01：	1
12	Clinical study evaluating efficacy of praziquantel in clonorchiasis显示文摘	Yangco BG De Lerma C Lyman GH	1987	Antimicrob Agents Chemother1987，31，2：	1
13	Enteroviral protease 2A cleaves dystrophin:Evidence of cytoskeletal disruption in an acquired cardiomyopathy显示文摘	Badorff C Lee GH Lamphear BJ	1999	Nat Med1999，5，3：	1
14	Enteroviral protease 2A cleaves dystrophin:evidence of cytoskeletal distrophion in an acgrired cardiomyopathy显示文摘	Badorff C Lee GH Lamphear BJ	1999	Nat Med1999，5，3：	1
15	Silk-based biomaterials显示文摘	Ahman GH Diaz F JAKUBA C Calabro T Horan RL Chen J	2003	Biomaterials2003，24，3：	1
16	The new ICP minimallyinvasive method shows that the Monro-Kellie doctrine is not valid显示文摘	Mascarenhas S Vilela GH Carlotti C	2012	Acta Neurochir Suppl2012，114，：	1
17	Hyper-IgG4 disease : report and characterisation of a new disease显示文摘	Neild GH Rodriguez-Justo M Wall C	2006	BMC Meal2006，4，：	1
18	GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis显示文摘	Yost C Farr GH Pierce SB	1998	Ce111998，93，：	1
19	Decreased pulmonary levels of the anti - inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmatics显示文摘	Lensmar C Nord M Gudmundsson GH	2000	Cell Mol Life Sci2000，57，6：	1
20	The effect of an inhibitor of adenylate cyclase on tile development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit显示文摘	Willies GH Woolf C J Rosendorff C	1976	Pflugers Arch1976，367，2：	1

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