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| 1 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 2 | Social competence among low-income preschoolers:emotion socialization practices and social cognitive correlates显示文摘 | GARNER P W J ONES D C MINER J L | 1994 | Child Development1994，65，2： | 1 |
| 3 | Detection of cervical cancer and high grade neoplastic lesions by a combination of liquid - based sampling preparation and DNA measurements using automated image cytometry 显示文摘 | Sun XR Wang J Garner D | 2005 | Cell Oncol2005，27，1： | 1 |
| 4 | Milrinone facilitates resuscitation from cardiac arrest and attenuates posttresuscitation myocardial dysfunction 显示文摘 | Niemann JT Garner D Khaleeli E | 2003 | Circulation2003，108，： | 1 |
| 5 | Ecological effects of particulate matter显示文摘 | Grantz D A Garner J H B Johnson D W | 2003 | Environment International2003，29，2： | 1 |
| 6 | Postoperative sequelae and complications of rhinoplasty 显示文摘 | Holt GR Garner ET McLarey D | 1987 | Otolaryngol Clin North Am1987，20，4： | 1 |
| 7 | The management of pulmonary embol- ism显示文摘 | Garner I)J Pilcher D | 2010 | Anaesth Intensive care2010，11，12： | 1 |
| 8 | Monophasic versus biphasic transthoracic countershock after prolonged ventricular fibrillation in a swine model 显示文摘 | Niemann J T Burian D Garner D | 2000 | J Am Coll Cardiol2000，36，3： | 1 |
| 9 | Relationship between fruit respiration,bruising susceptibility and temperature in sweet cherries显示文摘 | CRISOSTO C H GARNER D DOYLE DAY K R | 1993 | Hort Sci1993，28，： | 1 |
| 10 | Sex-Sorting mammalian sperm: concept to application in animals显示文摘 | Garner D L | 2001 | Androl2001，22，： | 1 |
| 11 | Milrinone facilitates resuscitation from cardiac arrest and attenuates postresuscitation myocardial dysfunction 显示文摘 | Niemann JT Garner D Khaleeli E | 2003 | Circulation2003，108，24： | 1 |
| 12 | Development of a shape memory alloy actuated biomimetie vehicle 显示文摘 | Garner L J Wilson L N Lagoudas D C | 2000 | Smart Materials and Structures2000，9，： | 1 |
| 13 | Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca^2+ influx 显示文摘 | DAS A GARNER D P DELRE A M | 2006 | Brain Res2006，1084，1： | 1 |
| 14 | Tumor necrosis factor-α is associated with early postresuscitation myocardial dysfunction显示文摘 | Niemann JT Garner D Roger J | 2004 | Crit Care Med2004，32，8： | 1 |
| 15 | The mechanism of alketene-dimer sizing of paper显示文摘 | Roberts J C Garner D N | 1985 | Tappi Journal1985，68，4： | 1 |
| 16 | Glass bead purification of plasmid template DNA for high throughput sequencing of mammalian genomes 显示文摘 | Dederich D A Okwuonu G Garner T | 2002 | Nucleic Acids Res2002，30，7： | 1 |
| 17 | Determination of unlabeled and ^13C6-labeled moricizine in hmuan plasma using thermospray liquid chmmatogramphy-mass spectrometry显示文摘 | PIENIASZEMK H J SHEN H L GARNER D M | 1989 | J Chromatogr1989，493，1： | 1 |
| 18 | Modelling of self-heating effect in thin SOI and partial SOI LDMOS power devices显示文摘 | LIM H T UDREA F GARNER D M | 1999 | Sol Sta Elec1999，43，12： | 1 |
| 19 | SOI power devices显示文摘 | UDREA F GARNER D SHENK | 2000 | Elec & Commoun Engineer J2000，12，1： | 1 |
| 20 | SOI power devices显示文摘 | UDREA F GARNER D SHENG K | 2000 | Elec and Commun Engineer J2000，12，1： | 1 |
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