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| 1 | Bacillus subtilis spore film dosimeters in personal dosimetry for occupational solar ultraviolet exposure显示文摘 | M. Moehrle M. Korn C. Garbe | 2000 | International Archives of Occupational and Environmental Health2000，，8： | 1 |
| 2 | Efficient nonmeiotic allele introgression in livestock using custom endonucleases显示文摘 | Wenfang Tan Daniel F. Carlson Cheryl A. Lancto John R. Garbe Dennis A. Webster Perry B. Hackett Scott C. Fahrenkrug | 2013 | Proceedings of the National Academy of Sciences2013，，41： | 1 |
| 3 | 皮敌菌素由外泌汗腺组成性产生,在皮肤感染情况下不能由表皮细胞诱导产生 | Rieg S. Garbe C. Sauer B. B.Schittek 田中伟 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，5： | 0 |
| 4 | 耳黑色素瘤的预后因素和外科治疗策略显示文摘Background: The ear’s specific anatomical and lymphatic characteristics impose special requirements on the treatment of melanoma of the ear. Objectives: The aim of this prospective study was to define prognostic factors for melanoma of the ear and to evaluate surgical strategies for excision margins, histological evaluation and sentinel lymph node biopsy (SLNB) in order to achieve better cosmetic and functional results. Patients and methods: One-hundred and sixty-one patients with stage I/II melanoma of the external ear were treated in the Department of Dermatology, University of Tuebingen, from March 1976 to March 2004 (median follow-up 62 months). Malignant melanoma of the external ear represented 3%of the stage I/II cutaneous melanomas and 20%of the stage I/II head and neck melanomas recorded in the Melanoma Registry of the Department of Dermatology at the University of Tuebingen. Twenty of 42 lentigo maligna melanomas (LMM) underwent conventional histological evaluation, 22 underwent complete three-dimensional histology of excision margins (3D histology) in a paraffin-technique, i.e. micrographic surgery. SLNB was performed in 28 patients with melanomas thicker than 1.0 mm. Clinical, histological and surgical risk factors were evaluated by univariate and multivariate analysis. Results: The median thickness of the tumours in the present study was 1.08 mm (mean 1.51 mm; range 0.18-8.50 mm), and the median excision margins were 11.0 mm (mean 12.61 mm; range 2.0-31.0 mm). The 3-year disease-specific survival rate was 98%, and the 3-year recurrence-free survival rate was 83%. Tumour thickness and invasion level were the only risk factors significant for disease-specific survival. Tumour thickness, location of the tumour and extent of excision margins were independently significant risk factors for recurrence free survival. LMMs removed surgically with accompanying 3D histology were thicker than those examined by conventional histology (median 0.93 mm vs. 0.83 mm). The use of surgery with 3D histology, i.e. micrographic surgery, made it possible to reduce the excision margins (median 5 mm vs. 10 mm) without an increased risk of recurrence. Two of 29 SLNBs were positive (6.9%). There were six preregional recurrences after negative SLNB and one after positive SLNB. None of the patients who underwent SLNB died of melanoma related causes during the observation period. Conclusions: This is the largest series of ear melanomas reported so far. The overall survival depended only on the tumour thickness and Clark level of invasion. Local recurrence was more frequent with smaller excision margins, but this did not influence the overall survival. Smaller excision margins under 3D-histological control did not carry an increased risk of local recurrence. Our results do not permit conclusions regarding the prognostic impact of SLNB for patients with melanoma of the ear. | Jahn V. Breuninger H. Garbe C. Moehrle M. 刘艳 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，6： | 0 |
| 5 | 应用数字皮肤镜筛检皮肤恶性黑色素瘤高危人群 | Bauer J. Blum A. Strohhcker U. Garbe C. 党倩丽 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，8： | 0 |
| 6 | 雀斑样恶性黑色素瘤的常规组织学和三维组织学比较显示文摘Background: Conventional surgery for lentigo maligna melanoma (LMM) is based on normal histological evaluation. However, such evaluation leaves diagnostic gaps. In contrast, complete three-dimensional (3D) histology of excision margins permits accurate detection of continuously spreading tumour strands like those of LMM. These can be specifically excised in tumour-positive areas with smaller excision margins, and better cosmesis and function. To date there have been no controlled studies of micrographic surgery of LMM. Objectives: Clinical parameters and surgical strategies influencing the prognosis of patients with LMM were evaluated in a prospective study of melanoma patients in the Department of Dermatology of the University of Tübingen (1980-99). Methods: The 292 LMMs comprised 7.4%of 3960 primary stage I and II melanomas treated during this period. One hundred and thirty-six patients in this group (46.6%) underwent surgery on the basis of 3D histology. Results: The geometric mean excision margins were significantly smaller in the 3D histology group (P < 0.0001). Patients with micrographic surgery had fewer recurrences. Multivariate analysis of clinical, histological and surgical variables was carried out, and tumour thickness and 3D histology proved to be independent, significant factors for the prognosis of recurrence-free survival (relative risk, RR 2.08, P < 0.0001 and RR 2.11, P = 0.0037, respectively). There were no melanoma-related deaths in the 3D histology group. All 16 melanoma-related deaths were observed among the 156 patients of the conventional histology group (10.3%). Conclusions: Excision of LMM using 3D histology resulted in a two fold lower probability of recurrence and two fold smaller excision margins. 3D histology is a valuable diagnostic tool and can be used in the management of LMM because of the latter’s pattern of continuous tumour spread. | MoehrleM. Dietz K. Garbe C. Breuninger H. 李晓莉 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，6： | 0 |
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