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| 1 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 2 | Policy priorities in diabetes care:a Delphi study显示文摘 | Gallagher M Bradshaw C Nattress H | 1996 | Qual Health Care1996，5，1： | 1 |
| 3 | The metabolic syndrome: Prevalence, CHD risk, and treatment 显示文摘 | Sarti C Gallagher J | 2006 | J Diabetes Complications2006，20，2： | 1 |
| 4 | Selective immu- nohistochemical comparison of polymorphous low-grade adenocarci- noma and adenoid cystic carcinoma 显示文摘 | Beltran D Faquin W C Gallagher G August M | 2006 | J Oral Maxillofac Surg2006，64，3： | 1 |
| 5 | Oxygen consumption at the soil--water interface in a Delaware salt marsh 显示文摘 | GALLAGHER J L DAIBER F C | 1974 | Chesapeake Science1974，15，： | 1 |
| 6 | Increased monocyte cytokine production in association with systemic complications in acute pancreatitis显示文摘 | Mckay C J Gallagher G Brooks B | | Br J Surg0，83，7： | 1 |
| 7 | Effect of poly- unsaturated fatty acids of the n-3 and n-6 series on lipid composi- tion and eicosanoid synthesis of platelets and aorta and on immu- nological induction of atherosclerosis in rabbits 显示文摘 | Bohon-Smith C Gibney MJ Gallagher PJ | 1988 | Atheroscle- rosis1988，72，1： | 1 |
| 8 | Sucrose and the integration of metabolism in vascular plants 显示文摘 | Farrar J Pollock C Gallagher J | 2000 | Plant Sci2000，154，： | 1 |
| 9 | A theoretical analysis of properties of the median filters 显示文摘 | Gallagher N C Wise G L | 1981 | IEEE Transactions on Acoustics Speech Signal Processing1981，29，1： | 1 |
| 10 | Effect of cadmium on glutathione S-transferase and metallothionein gene expression in coho salmon liver, gill and olfactory tissues显示文摘 | ESPINOZA H M WILLIAMS C R GALLAGHER E P | 2012 | Aquatic Toxicology2012，110，： | 1 |
| 11 | Current density of the arc cathode spot显示文摘 | Cobine J D Gallagher C J | 1948 | Physical Review1948，74，10： | 1 |
| 12 | Sucrose and the integration of metabolism in vascular plants显示文摘 | Farrar J Pollock C Gallagher J | 2000 | Plant Sci2000，154，： | 1 |
| 13 | Low-loss hollow-core silica/air photonic bandgap fibre显示文摘 | C M Smith N Venkataraman M T Gallagher | 2003 | Nature2003，424，6949： | 1 |
| 14 | A multicenter,open-label,prospective,randomized,dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome显示文摘 | Gallagher J Fisher C Sherman B | 2001 | Intensive Care Med2001，27，7： | 1 |
| 15 | Who cares ? The role of job involvement in psychological contract violation 显示文摘 | Stoner J S Gallagher V C | 2010 | Journal of Applied Social Psychology2010，40，6： | 1 |
| 16 | Congruent composition and Li-rich phase boundary of LiNbO3显示文摘 | O′BRYAN H M GALLAGHER P K BRANDLE C D | 1985 | J Am Ceram Soc1985，68，9： | 1 |
| 17 | Use of response surface methodology to produce functional short dough biscuits显示文摘 | Gallagher E O_Brien C M Scannell A G M | 2003 | Food Engineering2003，56，： | 1 |
| 18 | Natriuretic peptide-based screening and collaborative care for heart failure:the STOP-HF randomized trial显示文摘 | Ledwidge M Gallagher J Conlon C | 2013 | JAMA2013，310，1： | 1 |
| 19 | Demodexassociated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cellline:possible implications for corneal ulcer formation in ocular rosacea显示文摘 | O'Reilly N Gallagher C Reddy Katikireddy K | 2012 | Invest Ophthalmol Vis Sci2012，53，6： | 1 |
| 20 | Fast algorithm for the computation of the zero-order Hankel transform显示文摘 | Murphy P K Gallagher N C | 1983 | J Opt Soc Am1983，73，9： | 1 |
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