|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier. | Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 2 | Fresh- water diatom biogeography in the Canadian Arctic Archipela- go显示文摘 | BOUCHARD G GAJEWSKI K HAMILTON P B | 2004 | JournalofBiogeography2004，，31： | 1 |
| 3 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，23： | 1 |
| 4 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，： | 1 |
| 5 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia 显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Carttiol2001，77，： | 1 |
| 6 | Lower-extremity strength differences predict activity limitations in people with chronic stroke显示文摘 | Kluding P Gajewski B | 2009 | Phys Ther2009，89，1： | 1 |
| 7 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial Undas A Gajewski P | 2001 | Int J Cardiol2001，77，： | 1 |
| 8 | Anti - inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | MUSIAL U UNDAS A GAJEWSKI P | 2001 | Int J Cardiol2001，77，3： | 1 |
| 9 | anti-inflammatory effects of Simvastatin in subjects with hypercholesterolemia显示文摘 | Musisal J Undas A Gajewski P | 2001 | Int J Cardiol2001，7，： | 1 |
| 10 | A high resolution prexy-climate record from an arctic lake with annuallylaminated sediments on Devon Island, Nunavut, Canada 显示文摘 | Gajewski K Hamilton P B McNeely R | 1997 | Earth and Environment Science1997，17，21： | 1 |
| 11 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | 1 Int J Cardiol2001，77，： | 1 |
| 12 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia 显示文摘 | Undas A Gajewski P | 2001 | Int J Cardiol2001，77，： | 1 |
| 13 | Anti inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，2： | 1 |
| 14 | Antiinflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | IntJCardiol2001，77，23： | 1 |
| 15 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，23： | 1 |
| 16 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia 显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，3： | 1 |
| 17 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | | 0，，2： | 1 |
| 18 | Antiinflammation effects of simvasatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，： | 1 |
| 19 | Seismic velocities from the Yaquina forearc basin off Peru:evidence for free gas within the gas hydrate stability zone显示文摘 | Netzeband G L Hübscher C P Gajewski D | 2005 | International Journal of Earth Sciences2005，94，3： | 1 |
| 20 | A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor ceils expressing MAGE-3显示文摘 | Bruggen P Bastin J Gajewski T | 1994 | Eur J Immunol1994，24，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员