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| 1 | Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR显示文摘AIM: To determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these methods.METHODS: The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's f iles and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specif ic positive predictive value, negative predictive value, and accuracy.RESULTS: The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical fi ndings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. CONCLUSION: The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were low. | Maria Angela Bellomo-Brandao Paula D Andrade Sandra CB Costa Cecilia AF Escanhoela Jose Vassallo Gilda Porta Adriana MA De Tommaso Gabriel Hessel | 2009 | World Journal of Gastroenterology2009，15，27： | 8 |
| 2 | The CatWalk method: a detailed analysis of behavioral changes afteracute inflammatory pain in the rat显示文摘 | Gabriel AF Marcus MA Honig WM | 2007 | J Neurosci Methods2007，163，1： | 1 |
| 3 | Effect of moderate and severe heat stress on avian embryonic hsp70 gene expression显示文摘 | GABRIEL JE DA MOTA AF BOLELI IC | 2002 | Growth Dev Aging2002，66，1： | 1 |
| 4 | Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2) 显示文摘 | Berger V Gabriel AF Sergent T | 2003 | Toxicol Lett2003，，： | 1 |
| 5 | The CatWalk method: a detailed analysis of behavioral changes after acute inflammatory pain in the rat显示文摘 | Gabriel AF Marcus MA Honig WM | 2007 | J Neurusci Methods2007，163，1： | 1 |
| 6 | The CatWalk method: assessment of mechanical allodynia in experimental chronic pain显示文摘 | Gabriel AF Marcus MA Walenkamp GH | 2009 | Behav Brain Res2009，198，2： | 1 |
| 7 | The CatWalk method: a detailed analysis of behavioral changes after acute inflammatory pain in the rat显示文摘 | Gabriel AF Marcus MA Honig WM | 2007 | J Neurosci Methods2007，163，1： | 1 |
| 8 | The CatWalk method: assessment of mechanical allodynia in experimental chronic pain显示文摘 | Gabriel AF Marcus MA Walenkamp GH | 2009 | Behav Brain Res2009，198，2： | 1 |
| 9 | The CatWalk method:a detailed analysis of behavioral changes after acute inflammatory pain in the rat显示文摘 | Gabriel AF Marcus MA Honig WM | | 0，，01： | 1 |
| 10 | Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2) 显示文摘 | Berger V Gabriel AF Sergent T | 2003 | Toxicol Lett2003，，： | 1 |
| 11 | Delayed ripening of 'Bartlett' pears treated with nitrie oxide显示文摘 | Gabriel OS Gustavo DT Adela AF | 2003 | Journal of horticultural seienee and bioteehnology2003，78，6： | 1 |
| 12 | Analysis of the histologic features in the differential diagnosis of intrahepatic neonatal cholestasis显示文摘AIM:To compare the histologic features of the liver in intrahepatic neonatal cholestasis(IHNC)with infectious,genetic-endocrine-metabolic,and idiopathic etiologies. METHODS:Liver biopsies from 86 infants with IHNC were evaluated.The inclusion criteria consisted of jaundice beginning at 3 mo of age and a hepatic biopsy during the 1st year of life.The following histologic features were evaluated:cholestasis,eosinophilia,giant cells,erythropoiesis,siderosis,portal fibrosis,and the presence of a septum. RESULTS:Based on the diagnosis,patients were classified into three groups:group 1(infectious;n=18),group 2(genetic-endocrine-metabolic;n=18),and group 3(idiopathic;n=50).There were no significant differences with respect to the following variables:cholestasis,eosinophilia,giant cells,siderosis,portalfibrosis,and presence of a septum.A significant difference was observed with respect to erythropoiesis,which was more severe in group 1(Fisher's exact test,P=0.016). CONCLUSION:A significant difference was observed in IHNC of infectious etiology,in which erythropoiesis was more severe than that in genetic-endocrine-metabolic and idiopathic etiologies,whereas there were no significant differences among cholestasis,eosinophilia,giant cells,siderosis,portal fibrosis,and the presence of a septum. | Maria Angela Bellomo-Brandao Cecilia AF Escanhoela Luciana R Meirelles Gilda Porta Gabriel Hessel | 2009 | World Journal of Gastroenterology2009，15，4： | 0 |
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