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| 1 | Clinical significance of granuloma in Crohn's disease显示文摘AIM: Granuloma is considered the hallmark of microscopic diagnosis in Crohn's disease (CD), but granulomas can be detected in only 21-60% of CD patients. The aim of this studywas to evaluate the frequency of granulomas by multiple endoscopic biopsies in patients with CD and to examine whether group of patients with or without granuloma exhibit a different clinical course.METHODS: Fifty-six patients with newly diagnosed Cdwere included in the study. Jejunoscopy, enteroclysis and ileo-colonoscopy were performed in all patients. At least two biopsy specimens from each examined gastrointestinal segment were examined microscopically searching granuloma. The clinical course was followed in all patients, and extraintestinal manifestations as well as details of any immunosuppressive therapy and surgical intervention were noted.RESULTS: Granuloma was found in 44.6% of the cases (25 patients). Patients with granuloma had higher activity parameters at the time of the biopsies. Extraintestinal manifestations were observed and surgical interventions were performed more often in the granuloma group. The need of immunosuppressive therapy was significantly more frequent in the patients with granuloma. Granuloma formation is more often seen in younger patients, and mainly in the severe, active penetrating disease. CONCLUSION: The significantly higher frequency of surgical interventions and immunosuppressive therapy suggests that granuloma formation is associated with a more severe disease course during the first years of CD. | Tamás Molnár László Tiszlavicz Csaba Gyulai Ferenc Nagy János Lonovics | 2005 | World Journal of Gastroenterology2005，11，20： | 5 |
| 2 | Maintenance treatment outcomes in older patients with bipolar I disorder显示文摘 | SAJATOVIC M GYULAI L CALABRESE JR | 2005 | Am J Geriatr Psychiatry2005，13，4： | 1 |
| 3 | The current understanding of lamotrigine as a mood stabilizer显示文摘 | Hahn CG Gyulai L Baldassano CF | 2004 | J Clin Psychiatry2004，65，6： | 1 |
| 4 | Effects of the neuropeptides substance P,ealcitonin gene-related peptide and α-melanocyte-stimulating hormone on the IL-8/IL-8 receptor system in a caltured human keratinocyte cell line and dermal fibroblasts显示文摘 | Kiss M Kemeny L Gyulai R | 1995 | Inflammation1995，23，： | 1 |
| 5 | Effect of whole body vibration applied on upper extremity muscles显示文摘 | Gyulai G Rhcz L Di Giminiani R | 2013 | Acta Physiologica Hungarica2013，100，1： | 1 |
| 6 | Double-blind,placebocontrolled comparison of imipramine and paroxtine in the treatment of bipolar despression显示文摘 | Nemeroff CB Evans DL Gyulai L | 2001 | Am J Psychiatry2001，158，： | 1 |
| 7 | Maintenance treatment outcomes in older patients witn bipolar I disorder显示文摘 | Sajatovic M Gyulai L Calabrese JR | 2005 | AM J Geriatr Psychiatry2005，13，： | 1 |
| 8 | Human herpesvirus 8 DNA sequences in angiosarcoma of the face显示文摘 | Gyulai R Kem(e)ny L Kiss M | 1997 | Br J Dermatol1997，137，3： | 1 |
| 9 | Thyroid hypofunction in patients with rapid-cycling bipolar disorder after lithium challenge显示文摘 | GYULAI L BAUER M BAUER MS | 2003 | Biol Psychiatry2003，53，10： | 1 |
| 10 | Morphological and RAPD analysis of poplar trees of anther culture origin显示文摘 | KISS J KONDRAK M TORJEK O KISS E GYULAI G MAZIK TOKEI K HESZKY L E | 2001 | Euphytica2001，118，： | 1 |
| 11 | Effects of the neuropepUdes substance P, calcitonin gene-related peptide and alpha-melano- cyte-stimulating hormone on the IL-8/IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts 显示文摘 | Kiss M KemOny L Gyulai R | 1999 | Inflammation1999，23，6： | 1 |
| 12 | Maintenance efficacy of divalproex in the prevention of bipolar depression显示文摘 | Gyulai L Bowden CL McElroy SL | 2003 | Neuropsychopharmacology2003，28，： | 1 |
| 13 | Thyroid hypofunction in patients with rapid-cycling bipolar disorder after lithium challenge 显示文摘 | Gyulai L Bauer M Bauer MS | 2003 | Biol Psychiatry2003，53，10： | 1 |
| 14 | Effect of copper on shoot and root regenera-tion in wheat,triticale,rape and tobacco tissue culture显示文摘 | Purnhauser L Gyulai | 1993 | PlantCell Tissue and Organ Culture1993，35，： | 1 |
| 15 | Maintenance efficacy of divalproex in the prevention of bipolar depression显示文摘 | Gyulai L Bowden CL Mc Elroy SL | 2003 | Neuropsychopharmacology2003，28，7： | 1 |
| 16 | Effects of the neuropeptides substance P,calcitonin gene-related peptide and alpha-melanocyte-stimulating hormone on the IL-8/IL-8 receptor system in a cultured human Keratinocyte cell line and dermal fibroblasts显示文摘 | Kiss M Kemeny L Gyulai R | 1999 | Inflammation1999，23，6： | 1 |
| 17 | Doubleblind, placebo- controlled comparision of imipramine and paroxtine in the treatment of bipolar despression显示文摘 | Nerneroff CB Evans DL Gyulai L | 2001 | Am J Psychiatry2001，158，： | 1 |
| 18 | The current understanding of lamotrigine as a mood stabilizer显示文摘 | Hahn CG Gyulai L Baldassano CF | 2004 | J Clin Psychiatry2004，65，： | 1 |
| 19 | The current understanding of lamotrigine as a mood stabilizer显示文摘 | Hahn CG Gyulai L Baldassano CF | 2004 | J Clin Psychia- try2004，65，6： | 1 |
| 20 | Thyroid hypofunction in patients with rapid-cycling bipolar disorder after lithi- um challenge显示文摘 | Gyulai L Bauer M Bauer MS | 2003 | Biol Psychiatry2003，53，10： | 1 |
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