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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 3 | Characterization of flavonoids in cranberry (Vaccinium macrocarpon) powder显示文摘 | VVEDENSKAYA I O ROSEN R T GUIDO J E RUSSELL D J MILLS K A VORSA N | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 4 | A new role for cytoplasmic p53-binding and destroying double-stranded RNA显示文摘 | Lorenzo G Oliver K Guido K | 2010 | Cell Cycle2010，9，13： | 1 |
| 5 | Ex-framework FeZSM-5 for control of N2O in tail-gases显示文摘 | PEREZ R J FREEK K GUIDO M | 2002 | Catalysis Today2002，76，1： | 1 |
| 6 | Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection显示文摘 | Naztfa Qurishi Christina Kreuzberg Guido Lüchters Wolfgang Effenberger Bernd Kupfer Tilman Sauerbruch Jürgen K Rockstroh Ulrich Spengler | 2003 | The Lancet2003，，9397： | 1 |
| 7 | Sulphate moieties of heparan sulphate proteoglyeans associaued with senile plaques in Alzheimer's disease显示文摘 | Ilona B B Tom G Toin H K Guido D | 2008 | Alzheimer Dement2008，4，4： | 1 |
| 8 | Tunable block co- polymers based on a polysiloxane backbone by anionic ring-opening polymerization 显示文摘 | JOSEF B NICOLA H GUIDO K | 2004 | J Polym Sci Part A: Polym Chem2004，42，16： | 1 |
| 9 | IDH 1 and IDH 2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetic&lly Normal Acute Myeloid Leukemi&:A Cancer and Leukemia Group B Study显示文摘 | Guido M&rcucci K&ti M&h&rry Yue-Zhong Wu et &I | 2010 | Journal of Clinical Oncology2010，27，28： | 1 |
| 10 | Mobile robot programming using natural language显示文摘 | Stanislao L Guido B Theocharis K | 2002 | Robotics and Autonomous Systems2002，38，3： | 1 |
| 11 | Reliable engraftment,low toxicity, and durable remissions following allogeneic blood stem cell transplantation with minimal conditioning显示文摘 | Guido K Peter S Manuel A | 2002 | Exp Hematol2002，30，11： | 1 |
| 12 | Mitochondrial control of apoptosis: an introduction 显示文摘 | Guido K | 2003 | Biochemical and Biophysical Research Communications2003，304，3： | 1 |
| 13 | Comparative enzymatic hydrolysis of pretreated spruce by supernatants, whole fermentation broths and washed mycelia of Trichoderma reesei and Trichoderma atroviride显示文摘 | KRISZTINA K GEORGE S GUIDO Z | 2009 | Bioresource Technology2009，100，3： | 1 |
| 14 | Effect of antiretrovira therapy on liver-related mortality in patients with HIV and hepatitis C virus co-infection显示文摘 | Nazifa Q Christina K Guido L | 2003 | Lancet2003，362，22： | 1 |
| 15 | aL Com-bined Optimization of Spatial and Temporal Filter forImproving Brain-Computer Interfacing 显示文摘 | GUIDO D BENJAMIN B MATTHIAS K et | 2006 | IEEETransactions on Biomedical Engineering2006，53，11： | 1 |
| 16 | Viscoacoustic wave propagation in 2-D random media and separation of absorption and scattering attenuation 显示文摘 | Guido K Serge A S | 1995 | Geophysics1995，60，2： | 1 |
| 17 | Corporate social responsibility: a process model of sense-making显示文摘 | BASU K GUIDO P | 2008 | Academy of Manage- ment Re''dew2008，33，1： | 1 |
| 18 | The role of basic fibroblast growth factor in peripheral nerve regeneration显示文摘 | Claudia F Grothe S Guido K | 2001 | Anat Embryol (Berl)2001，204，2： | 1 |
| 19 | Noise reduction in 2D and 3D imaging by the CRS method显示文摘 | Gerald E K Juergen P Guido G | 2008 | The Leading Edge2008，，2： | 1 |
| 20 | Gene therapy for collateral vessel development显示文摘 | Guido M Marco S Imre K | 1997 | Cardiovascular Research1997，35，3： | 1 |
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