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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Effects of methotrexate on the developments of heart and vessel in zebrafish显示文摘Methotrexate (MTX ) , folic 酸的一个对手,能禁止在 tetrahydrofolic 酸和胚胎的开发的合成很重要的 dihydrofolate reductase (DHFR ) 。在这研究,我们在暴露于 1.5 以后发现了那 ? 在 610 个小时的公里 MTX 授精以后, zebrafish 胚胎没能形成正常心血管的系统。在对待 MTX 的胚胎,室和中庭的词法发展被破坏,心脏的扭曲是反常的,心率和室的弄短部分被减少,并且脉管的发展被破坏。我们也与钙盐五水合物(CF ) 能在对待 MTX 的胚胎在心和容器引起改进开发的 folinic 酸与 dhfrgfp mRNA 或处理发现那任何一个 microinjection,它证明那 MTX 由禁止 DHFR 导致了畸形性。象 hand2, mef2a, mef2c,和 flk-1 那样的基因的抄本层次在对待 MTX 的胚胎被减少。与对待 MTX 的组相比, hand2, mef2a, mef2c,和 flk-1 的抄本层次在 MTX + dhfrgfp 被增加注射 mRNA 的组并且在 MTX + CF 组。我们的结果显示在对待 MTX 的胚胎的心和容器的破坏发展与 hand2, mef2a, mef2c,和 flk-1 的减少的抄本层次有关。 | Shuna Sun Yonghao Gui Yuexiang Wang Linxi Qian Xuefei Liu Qiu Jiang Houyan Song | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 10 |
| 3 | Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish显示文摘Folic 酸为抑制能在脊椎动物引起先天的心缺点的胚胎的开发和 folic 酸是很重要的。Dihydrofolate reductase (DHFR ) 是在叶酸调停新陈代谢的关键酶。DHFR 的机能障碍破坏酸参予 folic 的关键生物过程。DHFR 基因在脊椎动物进化期间被保存。在心脏的开发调查 DHFR 的角色是重要的。在这研究,我们显示出那 DHFR 击倒在早阶段导致了 zebrafish 胚胎的反常开发。在心和流出道的明显的畸形性(经常) 也在 DHFR 击倒的胚胎被观察。DHFR overexpression 在 DHFR 击倒的组救了反常显型。DHFR NKX2.5 的表达式上的击倒的有的否定影响(NK2 抄写因素相关 5 ) , MEF2C (myocyte 特定的 enhancer 因素 2C ) , TBX20 (T 盒子 20 ) ,并且 TBX1 (T 盒子 1 ) 它在心脏的开发过程期间是重要 transcriptional 因素,当 DHFR overexpression 有积极效果时。DHFR 为刺猬小径被要求。DHFR 击倒的引起的减少的房间增长和增加的 apoptosis,当它的 overexpression 支持了房间增长并且禁止了 apoptosis 时。一起拿,我们的学习建议 DHFR 由调整基因抄写并且影响房间增长和 apoptosis 在 zebrafish 在心并且经常的发展起关键作用。 | Shuna Sun Yonghao Gui Qiu Jiang Houyan Song | 2011 | Acta Biochimica et Biophysica Sinica2011，43，12： | 5 |
| 4 | Fetal tissue Doppler imaging in pregnancies complicated with preeclampsia with or without intrauterine growth restriction显示文摘 | Qiongjie Zhou Yunyun Ren Yingliu Yan Chen Chu Yonghao Gui Xiaotian Li | 2012 | Prenat Diagn2012，，11： | 1 |
| 5 | Folic acid supplement rescues ethanol-induced developmental defects in the zebrafish embryos显示文摘Fetal alcohol syndrome(FASD)describes a range of birth defects.Mechanisms of FASD-associated defects are not well understood.It has great significance to investigate whether nutrient sup-plements like folic acid(FA)can effectively rescue etha nol-induced defects.Moreover,it is very important to determine the optimal time for FA supplementation when it can most effectively antagonize the teratogenic effects of ethanol during embryonic development.Our results indicated that ethanol exposure interrupted the development of zebrafish embryos and induced multiple defects in cardiac function,pharyngeal arch arteries,vessel,craniofacial cartilage,pharyngeal arches,brain,somite and hemoglobin formation.The expressions of critical genes that play important roles in above organs such as tbx1,flk-1,|hand2,ngn1,huc,titin,gata-1 and c-myb were reduced,and the apoptosis was increased in ethanol-treated group.FA supplementation could reverse ethanol-induced defects,improve the decreased expressions of above genes and reduce the apoptosis.We also found that giving FA at 6-12 h post-fertilization(hpf),which is at the gastrula period(5.25--10 hpf),can obviously prevent the teratogenicity of ethanol.This research provides clues for elucidating the mechanism of fetal abnormalties caused by alcohol intake and for preventing FASD. | Qiu Jiang Ding Lu Feng Wang Yawen Zhang Li Cao Yonghao Gui Shuna Sun | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 1 |
| 6 | Diurnal Temperature Range as a Novel Risk Factor for Sudden Infant Death显示文摘Objective To assess the relationship between diurnal temperature range (DTR) and sudden infant death (SID) between 2001 and 2004 in Shanghai,China.Methods We conducted a time‐stratified case‐crossover analysis to estimate the percent increase of SID associated with changes in DTR after adjustment for daily weather conditions (temperature and relative humidity) and outdoor air pollution.Results DTR was significantly associated with daily SID.An increase of 1 °C in the current‐day (L0) and in the 2‐day moving average (L01) DTR corresponds to a 1.56% (95% CI:0.97%,2.15%) and a 1.89% (95% CI:1.17%,2.60%) increase in SID,respectively.Conclusion An increased DTR was associated with an increased risk of SID in Shanghai.More studies are needed to understand the effect of DTR on infant deaths. | CHU Chen ZHOU WenHao GUI YongHao KAN HaiDong | 2011 | Biomedical and Environmental Sciences2011，24，5： | 0 |
| 7 | Identification and validation of cardiac nonconserved human-specific enhancers显示文摘Congenital heart disease(CHD)is one of the most common causes of neonatal mortality.The worldwide morbidity of CHD is 9.410%o,while the proportion of CHD patients who are reported to carry mutations in coding regions is<50%.Enhancers play an important role in the spatio-temporal expression of target genes,and a lot of related variations are associated with CHD.There are conserved and nonconserved enhancers. | Yawen Zhang Yiting Gui Xudong Chen Feng Wang Fang Wu Youhua Wang Xu Wang Yonghao Gui Qiang Li | 2023 | Genes & Diseases2023，10，1： | 0 |
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