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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | 米索前列醇和PG05配伍米非司酮终止早孕的临床多中心随机比较试验显示文摘本研究为一项由十个单位参加的多中心临床试验,随机比较了三种用药方案:1.米非司酮25mgQ12h×5+PG051mg阴道塞药(组Ⅰ),2.米非司酮,同前十米索600μg(组Ⅱ),3.米非司酮200mg+米索600μg(组Ⅲ)终止早孕的安全性、有效性和可接受性。结果显示完全流产率为94.22%(913/969),其中组Ⅲ为91.50%,明显低于组Ⅰ(95.22%)和组Ⅰ(96.12%)(P=0.025);失败率为1.65%(16/969),其中组Ⅲ为3.52%,显著高于组Ⅰ(1.37%)、组Ⅱ(0%)(P=0.001);不完全流产率为2.89%(28/969),失访(结局不明)率为1.24%(12/969),三组间均无明显差异(P>0.05);自应用PG至孕囊排出时间,三组分别为3.06±1.65,2.81±2.75,3.21±1.61h(X±SD),组Ⅱ稍短于其他两组,其差异有统计学意义(P<0.05);阴道出血持续时间和转经时间无明显组间差异(P>0.05)。90%以上的对象均对药物流产方法表示满意。结果提示米索配伍米非司酮的安全性、有效性和可接受性令人满意;米非司酮低剂量多次给药与米索有较好的协同作用。 | He Chang-hai Gao Er-sheng Chen Jun-hang Gu Jiang Gui You-lnn and Cao Feng-zhen et al.(Collabrating Grou) for Clinical Study on Misoprostol to induce Abortion, Shanghai, 200032) | 1994 | 生殖与避孕1994，14，1： | 47 |
| 3 | The efficacy and safety of endovascular recanalization of occluded large cerebral arteries during the subacute phase of cerebral infarction:a case series report显示文摘background Intravenous tissue plasminogen activator with or without mechanical thrombectomy during the acute phase are approved therapies for ischaemic stroke.Due to the short treatment time window(<6 hours)and often treatment failure,these patients would still have an intracranial arterial occlusion(IAO).It is unclear whether these patients can benefit from subsequent interventional recanalizationof their occluded artery in the subacute phase.In this retrospective study,we have examined the efficacy and safety in patients who have received either percutaneous transluminal angioplasty(PTA)or percutaneous transluminal angioplasty and stenting(PTAS)for IAO in the subacute phase of their stroke.Methods Patients with subacute symptomatic ischaemic stroke caused by IAO were assessed to identify the responsible artery and low perfusion areas by CT angiography,MR angiography or digital subtraction angiography.In eligible patients,a PTA or PTAS was performed to reopen the occluded artery.Regular antithrombotic therapy,use of statins,control of risk factors and rehabilitation therapy were prescribed after the procedure.All patients had regular follow-up up to 12 months.results PTA or PTAS was performed in 16 patients with cerebral infarction caused by IAO in the subacute phase.After the procedure,12 cases were recanalized,two were partially recanalized and two failed to open.One patient with left C6 segment occlusion of the carotid artery had a central retinal artery embolism after PTAS.The perioperative adverse events were 6.25%.At 3 months,the distribution of modified Rankin scale scores was 0(seven cases),1(three cases),2(five cases)and 3(one case).conclusion Selective PTA or PTAS could be performed in ischaemic stroke patients with a small infarct size and large area of hypoperfusion from an occluded large cerebral artery after the acute phase.It may improve neurological dysfunction and reduce the incidence of disability. | Kangning Chen Xianhua Hou Zhenhua Zhou Guangjian Li Qu Liu Li Gui Jun Hu Shugui Shi | 2017 | Stroke & Vascular Neurology2017，2，3： | 41 |
| 4 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 5 | Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells显示文摘目的: 间充质的干细胞(MSC ) 是心脏的代替治疗的一个有希望的候选人。然而,因为差的血供给, ischemia-reperfusion,和煽动性的因素,移植 MSC 的多数乐意地在移植以后被失去。我们试图在 MSC.Methods 的 hypoxia/reoxygenation-induced apoptosis 上学习组织缺氧 preconditioning ( HPC )的效果: MSC 的三代被划分成 6 个组包括正常的组, hypoxia-reoxygenation ( H/R )组, cyclosporine A ( CsA ),和 HPC 10 min , 20 min ,并且 30 min 组织。 apoptotic 索引,房间生存能力, mitochondrial 膜电位, Bcl-2 和 bax 的易位,细胞外的调整激酶(英皇家空军之阶级最低之兵), Akt ,组织缺氧可诱导的因素 1-alpha ,并且脉管的内皮生长因素( VEGF )在 H/R treatment.Results 以后被测试: HPC 减少了 apoptotic 索引并且增加了 H/R.Moreover 导致的生存能力, HPC 显著地稳定了 mitochondrial 膜电位在调整 Bcl-2 和 VEGF 表达式上面,并且增加了英皇家空军之阶级最低之兵和 Akt.As 的磷酸化积极控制, CsA 有象 HPC 的一样的函数,除了支持英皇家空军之阶级最低之兵和 Akt 磷酸化并且在调整 VEGF.Conclusion 上面: HPC 对 H/R 经由稳定 mitochondrial 膜电位导致的 MSC apoptosis 有保护的效果在调整 Bcl-2 和 VEGF 上面,并且支持英皇家空军之阶级最低之兵和 Akt phosphorylation.HPC 为新奇干细胞protective 策略的开发有含意。 | Jian-an WANG Tie-long CHEN Jun JIANG Heng SHI Chun GUI Rong-hua LUO Xiao-jie XIE Mei-xiang XIANG Xing ZHANG | 2008 | Acta Pharmacologica Sinica2008，29，1： | 25 |
| 6 | Process mineralogy of copper-nickel sulphide flotation by a cyclonic-static micro-bubble flotation column显示文摘In our study we investigated a refractory copper-nickel sulfide ore separation by using a cyclonic-static micro-bubble flotation column (FCSMC). The process mineralogy of the main products was studied. Using a scanning electron microscope-energy dispersive system (SEM-EDS) and an X-ray spectrometer the mineral category and content of samples were analyzed. By using a mineral liberation analyzer (MLA) the mineral liberation characteristics were revealed. It is shown that in roughing feed the monomers liberation degree of nickel pyrite and chalcopyrite take up 84.11% and 88.82%, respectively. In tailings, the lost nickel pyrite and chalcopyrite are mainly monomers. Therefore, strengthening the micro-fine particle recovery capacity is the key to increase recovery. | CAO Yi-jun GUI Xia-hui MA Zi-long YU Xiao-xia CHEN Xiao-dong ZHANG Xiu-pin | 2009 | Mining Science and Technology2009，19，6： | 25 |
| 7 | Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding显示文摘在 2002-2003 的 SARS 的全球爆发被新人的 coronavirus SARS-CoV 的感染引起。SARS-CoV 的感染主要通过病毒的表面 glycoproteins 被调停,它由 S1 和 S2 子单元组成并且在 virions 的信封上形成更整齐的尖铁。这里,我们报导处于单个粒子的 cryo 电子显微镜学决定的不同 conformational 状态更整齐的 SARS-CoV 表面尖铁的 ectodomain 结构。1 在 4.3 点决定了的符合构造?分辨率是三方面的对称并且有所有三受体绑定 C 终端域 1 (CTD1s ) S1 子单元在在位置下面。绑定下面到 SARS-CoV 受体 ACE2 的 CTD1s 不由于位的碰撞是可能的,建议 1 代表的符合构造受体绑定不活跃的状态。在 7.3, 5.7 和 6.8 点坚定的符合构造 2-4?决定都是不对称的,在哪个 RBD 旋转离开下面由不同角度到的位置一起来位置。起来 CTD1 为 ACE2 约会暴露受体绑定地点,建议符合构造 2-4 代表受体绑定活跃状态。这个 conformational 变化也为抵销指向 CTD1 的抗体的 SARS-CoV 的绑定被要求。这现象能被扩大到为受体绑定利用 S1 子单元的 CTD1 的另外的 betacoronaviruses,它提供新卓见进在感染期间更整齐的 coronavirus 熔化前尖铁的中间的状态。 | Miao Gui Wenfei Song Haixia Zhou Jingwei Xu Silian Chen Ye Xiang XinquanWang | 2017 | Cell Research2017，27，1： | 25 |
| 8 | The Impacts of Maternal Gestational Diabetes Mellitus (GDM) on Fetal Hearts显示文摘Objective To evaluate the fetal cardiac function in gestational diabetes mellitus (GDM) pregnancies under different maternal glycemic controls.Methods Forty four GDM mothers received 78 fetal echocardiographic evaluations at three gestational periods (<28,28-34 and ≥34 weeks) and were divided into poorly-(DM1) and well-(DM2) controlled groups according to their glycemic control at examination.Seventy uncomplicated mothers were selected as controls.Parameters of fetal cardiac anatomy and function were measured and analyzed.Results GDM fetuses' cardiac ventricular walls were thicker than controls',and the differences between DM1 and DM2 were not significant except for end-diastolic left ventricular walls.In both GDM groups,the aortic flow velocities increased earlier than pulmonary artery and DM1 fetuses changed earlier than DM2 ones.GDM fetuses' left atrial shortening fraction was smaller than the controls' in the period of ≥34 weeks and negatively correlated with thicknesses of left ventricular walls and interventricular septum in DM1 fetuses (r=-0.438 and -0.506).The right ventricular diastolic function in DM1 and DM2 fetuses decreased after the period of 28-34 weeks and in the period of ≥34 weeks respectively.Tei index of both left and right ventricles increased in DM1 group after the period of<28 weeks and in DM2 group only in the period of ≥34 weeks,with no significant differences between DM1 and DM2 groups in this period.Conclusion Fetuses of GDM mothers showed cardiac function impairments.Good maternal glycemic control may delay the impairments,but cannot reduce the degree.Some cardiac changes in GDM fetuses were similar to those in pregestational diabetic pregnancies except for several parameters and their changing time. | CHU Chen GUI Yong Hao PEN Yun Yun SHI Li Ye | 2012 | Biomedical and Environmental Sciences2012，25，1： | 20 |
| 9 | Optimal time for mesenchymal stem cell transplantation in rats with myocardial infarction显示文摘Background:Bone marrow mesenchymal stem cell (MSC) transplantation is a promising strategy in the treatment of myocardial infarction (MI). However, the time for transplanting cells remains controversial. The aim of this study was to find an optimal time point for cell transplantation. Methods: MSCs were isolated and cultured from Sprague-Dawley (SD) rats. MI model was set up in SD rats by permanent ligation of left anterior descending coronary artery. MSCs were directly injected into the infarct border zone at 1 h, 1 week and 2 weeks after MI, respectively. Sham-operated and MI control groups received equal volume of phosphate buffered saline (PBS). At 4 weeks after MI, cardiac function was assessed by echocardiography; vessel density was analyzed on hematoxylin-eosin stained slides by light microscopy; the apoptosis of cardiomyocytes was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay; the expressions of proteins were analyzed by Western blot. Results: MSC transplantation improved cardiac function, reduced the apoptosis of cardiomyocytes and increased vessel density. These benefits were more obvious in 1-week group than in 1-h and 2-week groups. There are more obvious in-creases in the ratio of bcl-2/bax and the expression of vascular endothelial growth factor (VEGF) and more obvious decreases in the expression of cleaved-caspase-3 in 1-week group than those in other two groups. Conclusion: MSC transplantation was beneficial for the recovery of cardiac function. MSC transplantation at 1 week post-MI exerted the best effects on increases of cardiac function, anti-apoptosis and angiogenesis. | Chen-yang JIANG Chun GUI Ai-na HE Xin-yang HU Jie CHEN Yun JIANG Jian-an WANG | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，8： | 18 |
| 10 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 11 | High sensitive C-reactive protein, adiponectin, and urine albumin excretion rate in Chinese coronary artery disease patients with different glucose tolerance status显示文摘背景浆液高敏感的 C 反应的蛋白质(hs-CRP ) , adiponectin 层次和尿白朊排泄率(UAER ) 可能与发炎和动脉粥样硬化被联系。学习是在冠的动脉疾病( CAD )决定三个标记的这的目的在一张中国人口并且进一步与不同葡萄糖忍耐地位使遭到与 CAD 风险因素和 CAD 的严厉在这些题目和这些标记的可能的协会探索三个标记的层次也。有 angiographically 记录的 CAD 的 242 个题目全部的方法 A 被招募,然后把组分到三:正常葡萄糖忍耐(NGT )+ CAD 组,与 NGT 包括 100 个 CAD 病人;损害葡萄糖忍耐(IGT )+ CAD 组,有 IGT 的 40 个 CAD 病人;类型 2 糖尿病 mellitus (T2DM )+ CAD 组,有 T2DM 的 102 个 CAD 病人。浆液 hs-CRP, adiponectin 层次以及 UAER 在所有题目被测量。结果浆液 hs-CRP 层次与 NGT + CAD 组相比在 T2DM + CAD 组被增加(4.71 瀠瑡敩瑮 ? 楷桴瀠汵潭慮祲愠瑲牥慩? | GUI Ming-hui HONG Jie LU An-kang CHEN Ying SHEN Wei-feng LI Xiao-ying NING Guang | 2008 | Chinese Medical Journal2008，，24： | 14 |
| 12 | Neuroprotective effects of tetrandrine against vascular dementia显示文摘Tetrandrine is one of the major active ingredients in Menispermaceae Stephania tetrandra S.Moore,and has specific therapeutic effects in ischemic cerebrovascular disease.Its use in vascular dementia has not been studied fully.Here,we investigated whether tetrandrine would improve behavioral and cellular impairments in a two-vessel occlusion rat model of chronic vascular dementia.Eight weeks after model establishment,rats were injected intraperitoneally with 10 or 30 mg/kg tetrandrine every other day for 4 weeks.Behavioral assessment in the Morris water maze showed that model rats had longer escape latencies in training trials,and spent less time swimming in the target quadrant in probe trials,than sham-operated rats.However,rats that had received tetrandrine showed shorter escape latencies and longer target quadrant swimming time than untreated model rats.Hematoxylin-eosin and Nissl staining revealed less neuronal necrosis and pathological damage,and more living cells,in the hippocampus of rats treated with tetrandrine than in untreated model rats.Western blot assay showed that interleukin-1β expression,and phosphorylation of the N-methyl-D-aspartate 2B receptor at tyrosine 1472,were lower in model rats that received tetrandrine than in those that did not.The present findings suggest that tetrandrine may be neuroprotective in chronic vascular dementia by reducing interleukin-1β expression,N-methyl-D-aspartate receptor 2B phosphorylation at tyrosine 1472,and neuronal necrosis. | Yan-ling Lv Ze-zhi Wu Li-xue Chen Bai-xue Wu Lian-lian Chen Guang-cheng Qin Bei Gui Ji-ying Zhou | 2016 | Neural Regeneration Research2016，11，3： | 13 |
| 13 | Synthesis and Characterization of Phosphated Konjac Glucomannan Hydrogels显示文摘Konjac glucomannan (KGM) was crosslinked with sodium tripolyphosphate (STPP) to synthesize hydrogels. The crosslinking reaction was confirmed by FT-IR. The results of degradation test show that the hydrogels retain the enzymatic degradation character of KGM and can be degraded for 74.45% in 5 days by cellulase E0240. | Li Gui CHEN Zhi Lan LIU Ying Jun CHEN Ren Xi ZHUO | 2005 | Chinese Chemical Letters2005，16，12： | 13 |
| 14 | Increase of TNFα-stimulated Osteoarthritic Chondrocytes Apoptosis and Decrease of Matrix Metalloproteinases 9 by NF-κB Inhibition显示文摘Objective To investigate the in vitro effect of caffeic acid phenethyl ester(CAPE),a NF-κB inhibitor,on the apoptosis of osteoarthritic(OA)chondrocytes and on the regulation of the gelatinases matrix metalloproteinase 2(MMP-2)and matrix metalloproteinase 9(MMP-9).Methods Annexin V-FITC/propidium iodide(PI)labeling and western blotting were used to observe and determine the apoptosis in TNFα-stimulated primary cultured osteoarthritic chondrocytes.Also,gelatin zymography was applied to examine MMP-2 and MMP-9 activities in supernatants.Results It was confirmed by both flow cytometry and western blotting that chondrocytes from OA patients have an apoptotic background.Use of CAPE in combination with 10 ng/mL of TNFα for 24 h facilitated the apoptosis.MMP-9 in the supernatant could be autoactivated(from proMMP-9 to active MMP-9),and the physiologic calcium concentration(2.5 mmol/L)could delay the autoactivation of MMP-9.The activities of MMP-2 and MMP-9 in the fresh supernatant increased significantly in response to stimulation by 10 ng/mL of TNFα for 24 h.The stimulatory effect of TNFα just on proMMP-9 was counteracted significantly by CAPE.Conclusion NF-κB could prevent chondrocytes apoptosis though its activation was attributed to the increase of proMMP-9 activity induced by TNFα(a pro-apoptotic factor).Therefore,therapeutic NF-κB inhibitor was a 'double-edged swords' to the apoptosis of chondrocytes and the secretion of MMP-9. | WANG Yan LI De Ling ZHANG Xin Bo DUAN Yuan Hui WU Zhi Hong HAO Dong Sheng CHEN Bao Sheng QIU Gui Xing | 2013 | Biomedical and Environmental Sciences2013，26，4： | 13 |
| 15 | A knowledge reasoning Fuzzy-Bayesian network for root cause analysis of abnormal aluminum electrolysis cell condition显示文摘 | Weichao Yue Xiaofang Chen Weihua Gui Yongfang Xie Hongliang Zhang | 2017 | Frontiers of Chemical Science and Engineering2017，11，3： | 13 |
| 16 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 17 | High-detectivity InAs nanowire photodetectors with spectral response from ultraviolet to near-infrared显示文摘InAs 是直接、狭窄的乐队差距(0.354 eV ) 材料与超离频电子活动性,并且潜在地在宽 UV-visible-near-infrared 区域的一个好 optoelectronic 设备候选人。在这个工作,我们报导 InAs 基于 nanowire 的光电探测器的制造,它在一个女人上显示出很高的 photoresponse 光谱从 300 ~ 1,100 nm 的范围。responsivity,外部量效率和设备的 detectivity 分别地被测量是有用在一台原子力量显微镜(AFM ) 之间产生的高静电的地的 nanoscopic 精确的 4.4 张 y 还原剂 graphene 氟化物(GF ) 表尖端和 GF 底层。由电场的氟的符号的减小急速地与表抵抗力与 105-1,800 nm 的宽度生产 graphene nanoribbons (GNR ) 减少了从 > 1 T ???????? ? ? | Zhe Liu Tao Luo Bo Liang Gui Chen Gang Yu Xuming Xie Di Chen Guozhen Shen | 2013 | Nano Research2013，6，11： | 12 |
| 18 | Diet and gastric cancer:a case-control study in Fujian Province,China显示文摘NTRODUCTIONChangleandFuqingcitiesarelocatedinthesoutheasternpartofFujianProvince,Chinawithahighincidenceofgastriccancer.Howev... | YE Wei Min 1, YI Ying Nan 1, LUO Ren Xia 2, ZHOU Tian Shu 3, LIN Ru Tao 1 and CHEN Gui Dong 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 12 |
| 19 | Instability mechanism and control technology of soft rock roadway affected by mining and high confined water显示文摘Based on deformation and failure characteristics of the second belt conveyor roadway at level II of Zhuxianzhuang coal mine, laboratory experiments, numerical calculation and field test were adopted to analyze the composition and microstructure of mudstone, the law of mudstone hydration and its strength weakening induced by water, the characteristics of surrounding rock deformation and failure under the action of confined water. Results showed that montmorillonite clay minerals accounted for as much as 76% of mudstone, with a large number of pores existing in the microstructure. Besides, as the molecular structure of montmorillonite changed, mudstone microstructure damage occurred with the macroscopic manifestation of its rheological instability. Weakening degree of confined water on residual strength of mudstone was almost 50%. The instability mechanism of soft rock roadway caused by high confined water is that surrounding rock circulates the process of ‘‘fracture-seepage-mud ding-closed'' twice, which weakens its strength and leads to roadway instability. A combined support technology, namely the, ‘‘high-toughness sealing layer + hollow grouting cables + full-length anchoring bolts with deep borehole'' was proposed. Based on field observation, the soft rock roadway was controlled effectively, which also verified the effectiveness of new control technology for surrounding rock. | Li Guichen Jiang Zuohan Lv Chuangxin Huang Chao Chen Gui Li Mingyuan | 2015 | International Journal of Mining Science and Technology2015，25，4： | 11 |
| 20 | Pregnancy outcomes and risk factors for low birth weight and preterm delivery among HIV-infected pregnant women in Guangxi, China显示文摘在中国的背景六省在 2009 和五个省在这个国家说明了所有报导 HIV/AIDS 案例的 70-80 说明了属于的 HIV cases.Because Guangxi 的 78 所有报导 mother-to-child 传播( MTCT )两个组,加节目的 Mother-to-Child 传播( PMTCT )的预防在那里被建立理解更好低的出生重量( LBW )和 preterm 交货( PD )出生结果和他们的联系风险因素 better.Methods 怀孕结果被检验在之中95 CI 1.11-25.55 ) 并且 CD4 房间计数 100-199 cells/l (AOR 3.40;95 Cl 1.03-11.25,与 CD4 房间计数 350 cells/l 相比) , gestational 年龄 37 星期(AOR 4.38;95 CI 1.29-14.82,与 37 个星期相比) ,母亲的重量 45 kg (AOR 5.64;95 Cl 1.09-29.07 ) 并且母亲的重量 45-54 kg (AOR 3.55;95 Cl 1.31-9.60,与 55 kg 相比) 在注册,和 HIV RNA 100 在注册的 000 copies/ml (AOR 4.22;95 Cl 1.24-14.32 ) 并且 20 000-99 999 (AOR 2.77;95 CI 1.01-7.77,与 20 000 copies/ml 相比) 与 LBW.For PD 的更高的风险被联系,仅仅母亲的注射药使用作为 HIV 传播的线路(AOR 5.30; 95 CI 1.33-21.14 ,与通过性传播感染 HIV 的那些相比)显著地与 PD.Conclusions 更低的 CD4 房间计数的更高的风险被联系,在注册的更高的 HIV RNA 病毒的负担与 LBW.Optimal 胎儿的照顾被联系包括更早胎儿的屏蔽和 HIV 诊断,对更早的 PMTCT 预防或 HIV treatent 批评阻止 HIV 的传播到婴儿并且也阻止 LBW 怀孕结果。 | Yu Lan Li Wen-ying Chen, Ray Y. Tang Zhi-rong Pang Jun Gui Xiu-zhi Meng Xiu-ning Zhang Fu-jie | 2012 | Chinese Medical Journal2012，，3： | 10 |
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