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| 1 | CB-Dock: a web server for cavity detection-guided protein–ligand blind docking显示文摘As the number of elucidated protein structures is rapidly increasing,the growing data call for methods to efficiently exploit the structural information for biological and pharmaceutical purposes.Given the three-dimensional(3D)structure of a protein and a ligand,predicting their binding sites and affinity are a key task for computer-aided drug discovery.To address this task,a variety of docking tools have been developed.Most of them focus on docking in the preset binding sites given by users.To automatically predict binding modes without information about binding sites,we developed a user-friendly blind docking web server,named CB-Dock,which predicts binding sites of a given protein and calculates the centers and sizes with a novel curvature-based cavity detection approach,and performs docking with a popular docking program,Autodock Vina.This method was carefully optimized and achieved^70% success rate for the top-ranking poses whose root mean square deviation(RMSD)were within 2Åfrom the X-ray pose,which outperformed the state-of-the-art blind docking tools in our benchmark tests.CB-Dock offers an interactive 3D visualization of results,and is freely available at http://gffzzdb39119b70414d18h90kxovcookwc6own.ffgz.tsg.suse.edu.cn/cb-dock/. | Yang Liu Maximilian Grimm Wen-tao Dai Mu-chun Hou Zhi-Xiong Xiao Yang Cao | 2020 | Acta Pharmacologica Sinica2020，41，1： | 36 |
| 2 | 新版Tilia软件:中文指南和使用技巧显示文摘Tilia软件一直是微体古生物学特别是孢粉学科使用最为普遍的一款专业计算机程序。该软件主要将样品数据经统计计算分析,将每个样品化石科属类型含量以图谱的形式依据地层深度或时间顺序排列显示,使化石数据转换为地层图式。基于各科属特别是优势或建群类型含量上下层位变化特点和规律,划分生物组合带,以图的形式直观解读生物群落的地史演替和环境变化等科学问题。由于此软件一直在英文语境下运行,功能多样,操作较为复杂,往往令国内初学者难以入手和深入。本文将以新版Tilia 2.0.45软件为对象,基于先期积累的使用经验,结合我国学者的思维方式,通过简单的孢粉数据实例,图解步骤和过程,力求通俗易懂。为此,推出'基础版'和'高阶版'两种使用说明以满足不同层次的人员需求,前者针对初学者旨在短时间内快速入门掌握孢粉百分比图谱制作的基本技巧,后者面向有一定操作经验学者力求在浓度图谱、通量图谱及'深度-年代'模型和Neotoma全球生态数据库等方面拓展提高。 | 舒军武 黄小忠 徐德克 陈炜 宋兵 崔安宁 Eric Grimm | 2018 | 古生物学报2018，57，2： | 10 |
| 3 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 4 | The Potato Sucrose Transporter StSUT1 Interacts with a DRM-Associated Protein Disulfide Isomerase显示文摘进建筑群的蛋白质的组织为许多细胞的功能是关键的。最近, SUT1 蛋白质被显示形成 homodimeric 建筑群,到与类脂化合物被联系在酵母以及在植物并且到的像木排的 microdomains 响应 brefeldin A 经历 endocytosis。我们因此试图识别可能涉及 dimerization 的交往 SUT1 蛋白质, endocytosis,或 SUT1 指向到像木排的 microdomains。因此,我们识别了土豆膜蛋白质,它与净化抵抗的膜(DRM ) 被联系部分。在识别的蛋白质之中,我们清楚地在土豆来源叶子作为 DRM 的部分证实了 StSUT1。我们使用了酵母二混血儿的裂口 ubiquitin 系统(怀疑) 系统地在 vivo 为在蔗糖 transporter StSUT1 和另外的联系膜或可溶的蛋白质之间的相互作用屏蔽。SUS 屏幕被 immunoprecipitation 用净化亲密关系的 StSUT1 特定的肽抗体和一同沉淀的蛋白质的集体度谱的分析跟随。大重叠在在 co-immunoprecipitation 和净化抵抗的膜部分识别的交往 StSUT1 蛋白质之间被观察。交往 SUT1 蛋白质之一,蛋白质二硫化物 isomerase (PDI ) ,与另外的蔗糖 transporter 蛋白质也交往。护卫蛋白质被讨论的 PDI 的一个潜在的角色。 | Undine Krugel Hong-Xia He Konstanze Gier Jana Reins Izabela Chincinska Bernhard Grimm Waltraud X. Schulze Christina Kuhn | 2012 | Molecular Plant2012，5，1： | 7 |
| 5 | GUN4 Is Required for Posttranslational Control of Plant Tetrapyrrole Biosynthesis显示文摘在氧气的光合的有机体, GUN4 绑叶绿素中介 protoporphyrin 和 Mg protoporphyrin,刺激 Mg chelatase 活动,并且在 plastidic 被含有后退发信号。GUN4 表示很充满幼仔和 greening 纸巾和平行 5-aminolevulinic 酸(翼) 的活动翼和 Mg 卟啉生合成在 photoperiodic 生长期间。我们探索了 GUN4 缺乏的使用的 GUN4 和 overexpressing 植物的行动的功能和模式。GUN4 overexpression 导致叶绿素生合成的酶的一般激活。在 photoperiodic 生长 GUN4 期间,缺乏阻止翼合成和叶绿素累积。所有这些新陈代谢的变化不在 tetrapyrrole 生合成与改变的基因表示或蛋白质丰富的变化相关。当翼喂没能在 lightdark 生长期间补偿 GUN4 缺乏时,这条途径在连续的暗淡的光下面导致叶绿素累积。一个新模型在翼和 Mg 卟啉合成的 posttranslational 规定定义 GUN4 的参与,到支撑叶绿素合成,也就是在改变环境条件下面。 | Enrico Peter Bernhard Grimm | 2009 | Molecular Plant2009，2，6： | 7 |
| 6 | Localized bursting of mesocarp cells triggers catastrophic fruit cracking显示文摘The so-called rain-cracking of sweet cherry fruit severely threatens commercial production.Simple observation tells us that cuticular microcracking(invisible)always precedes skin macrocracking(visible).The objective here was to investigate how a macrocrack develops.Incubating detached sweet cherry fruit in deionized water induces microcracking.Incubating fruit in D2O and concurrent magnetic resonance imaging demonstrates that water penetration occurs only(principally)through the microcracks,with nondetectable amounts penetrating the intact cuticle.Optical coherence tomography of detached,whole fruit incubated in deionized water,allowed generation of virtual cross-sections through the zone of a developing macrocrack.Outer mesocarp cell volume increased before macrocracks developed but increased at a markedly higher rate thereafter.Little change in mesocarp cell volume occurred in a control zone distant from the crack.As water incubation continued,the cell volume in the crack zone decreased,indicating leaking/bursting of individual mesocarp cells.As incubation continued still longer,the crack propagated between cells both to form a long,deep macrocrack.Outer mesocarp cell turgor did not differ significantly before and after incubation between fruit with or without macrocracks;nor between cells within the crack zone and those in a control zone distant from the macrocrack.The cumulative frequency distribution of the logtransformed turgor pressure of a population of outer mesocarp cells reveals all cell turgor data followed a normal distribution.The results demonstrate that microcracks develop into macrocracks following the volume increase of a few outer mesocarp cells and is soon accompanied by cell bursting. | Eckhard Grimm Jan Hahn Daniel Pflugfelder Moritz Jonathan Schmidt Dagmar van Dusschoten Moritz Knoche | 2019 | Horticulture Research2019，6，1： | 5 |
| 7 | Recycling of Solanum Sucrose Transporters Expressed in Yeast, Tobacco, and in Mature Phloem Sieve Elements显示文摘植物蔗糖 transporter SUT1 (从茄属 tuberosum, S。lycopersicum,或 Zea mays ) 展览氧化还原作用依赖者 dimerization 并且如果 heterologously 在 S 表示了,指向。cerevisiae (Kr ?????????????? 敌呈′ ???????? 汧' 租?? 猠浹潰瑲牥?? | Johannes Liesche Hong-Xia He Bernhard Grimm Alexander Schulz Christina Kuhn | 2010 | Molecular Plant2010，3，6： | 4 |
| 8 | 美国的放射学医师培训显示文摘在美国,要成为一个真正的放射科医师,必须经历一个非常严格的多层次、多步骤的学习,并经过严格的考试和临床应用培养的过程,且这个过程是被严格规范管理的。 | Grimm LJ Maxfield CM 陈君彦 | 2011 | 中华放射学杂志2011，45，11： | 4 |
| 9 | Campylobacter concisus and inflammatory bowel disease显示文摘Investigation of the possible role of Campylobacter concisus(C. concisus) in inflammatory bowel disease(IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may contribute to the development of enteric diseases. The evidence presented in this review shows that some C. concisus strains in the oral cavity acquired zonula occludens toxin(zot) gene from a virus(prophage) and that C. concisus Zot shares conserved motifs with both Vibrio cholerae Zot receptor binding domain and human zonulin receptor binding domain. Both Vibrio cholerae Zot and human zonulin are known to increase intestinal permeability by affecting the tight junctions. Increased intestinal permeability is a feature of IBD. Based on these data, we propose that a primary barrier function defect caused by C. concisus Zot is a mechanism by which zot-positive C. concisus strains may trigger the onset and relapse of IBD. | Li Zhang Hoyul Lee Michael C Grimm Stephen M Riordan Andrew S Day Daniel A Lemberg | 2014 | World Journal of Gastroenterology2014，20，5： | 4 |
| 10 | Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts显示文摘自然照明条件是高度可变的并且因为他们的无柄的生活方式,植物在细胞、分子的水平被强迫到 acclimate 到他们。在轻紧张或质量的变化在减小 / 氧化(氧化还原作用) 导致变化为包括光合作用和新陈代谢的功能、结构的调整的补偿环境适应回答充当一个扳机的光合的电子链的状态。如此的回答在原子核和细胞器在植物基因表示包括控制氧化还原作用的变化。这里,我们在模型有机体 Arabidopsis thaliana 的原子核为早调整氧化还原作用的基因(尔格) 的鉴定描述策略显著地回答 30 或在在光合的电子运输链的一个减小信号的产生以后的 60min。由把野类型的植物的反应与环境适应异种 stn7 的作比较,我们能明确地识别尔格。结果为 mitochondrial 电子运输链, tetrapyrrole 生合成,糖类新陈代谢,和发信号的类脂化合物合成包括基因在不同原子基因组上揭示叶绿体氧化还原作用信号的重要影响。这些表示侧面与响应光合的电子 transportby 的减小观察的那些清楚地不同高轻的处理。因此,识别的尔格对在光合的电子运输的氧化还原作用不平衡唯一并且然后被使用分析潜在的氧化还原作用应答的 cis 元素, trans 因素,和 chromosomal 规章的热点。数据识别一个新奇氧化还原作用应答的元素并且在在 epigenetic 进程上指向氧化还原作用信号的崭新的影响的 transcriptional 和 chromosomal 层次显示广泛的氧化还原作用控制。 | Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt | 2015 | Molecular Plant2015，8，8： | 4 |
| 11 | Music in depression: Neural correlates of emotional experience in remitted depression显示文摘AIM: To investigate neural and behavioral correlates of emotional experiences as potential vulnerability markers in remitted depression. METHODS: Fourteen remitted participants with a history of major depression and fourteen closely matched healthy control participants took part in the study. We used two psychiatric interviews(Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale) and one self-report scale(Beck Depression Inventory) to assess remission. Healthy control participants were interviewed by an experienced psychiatrist to exclude those who showed any current or lifetime psychiatric or neurological disorders. To explore psychosocialand cognitive-interpersonal underpinnings of potential vulnerability markers of depression, early life stress, coping styles and alexithymia were also assessed. We induced pleasant and unpleasant emotional states using congruent combinations of music and human emotional faces to investigate neural and behavioral correlates of emotional experiences; neutral stimuli were used as a control condition. Brain responses were recorded using functional magnetic resonance imaging. Behavioral responses of pleasantness, arousal, joy and fear were measured via button-press inside the resonance imaging scanner. RESULTS: The mean age of the sample was 54.9(± 11.3) years. There were no differences between remitted depressed(RD)(n = 14; 9 females and 5 males) and healthy participants(n = 14; 8 females and 6 males) regarding age, current degree of depression, early life stress, coping styles and alexithymia. On a neural level, RD participants showed reduced activations in the pregenual anterior cingulate cortex(pg ACC) in response to pleasant [parameter estimates:-0.78 vs 0.32; t(26) =-3.41, P < 0.05] and unpleasant [parameter estimates:-0.88 vs 0.56; t(26)=-4.02, P < 0.05] emotional stimuli. Linear regression analysis revealed that pg ACC activity was modulated by early life stress [β =-0.48; R2 = 0.23, F(1,27) = 7.83, P < 0.01] and taskoriented coping style [β = 0.63; R2 = 0.37, F(1,27) = 16.91, P < 0.001]. Trait anxiety modulated hippocampal responses to unpleasant stimuli [β = 0.62; R2= 0.38, F(1,27) = 15.95, P < 0.001]. Interestingly, in their reported experiences of pleasantness, arousal, happiness and fear in response to pleasant, unpleasant and neutral stimuli, RD participants did not differ significantly from healthy control participants. Adding trait anxiety or alexithymia as a covariate did not change the results.CONCLUSION: The present study indicates that, in euthymic individuals, depression history alters neural correlates, but not the subjective dimension of pleasant and unpleasant emotional experiences. | Sabine Aust Karin Filip Stefan Koelsch Simone Grimm Malek Bajbouj | 2013 | World Journal of Psychiatry2013，3，2： | 3 |
| 12 | Induced Deactivation of Genes Encoding Chlorophyll Biosynthesis Enzymes Disentangles Tetrapyrrole- Mediated Retrograde Signaling显示文摘在光合的有机体,调停 tetrapyrrole 后退信号被建议在叶绿体响应新陈代谢的活动贡献平衡原子 geneexpression (NGE ) 。我们跟随了一条试验性的短期的途径对修改 NGE 的那个 allowedthe 评价 tetrapyrrolebiosynthesis 在 Mg 的明确地修改的酶的步骤的第一个小时期间分叉,当另外的信号的多种的效果能被避免时。响应编码 Mg chelatase, Mg protoporphyrin methyltransferase 和 Mg protoporphyrin monomethylestercyclase 的 CHLH 子单元的 CHLH, CHLM,和 CHL27 的 24-h-induced silencing,分别地,撤销的基因表示很快导致了相应的酶和 alteredMg 卟啉层次的减少的活动。但是 NGE 实质地没被改变。这三基因什么时候连续地在 to4 d 上面被使失去活性为,原子基因的抄本层次的变化被决定。为在坏死的叶损害和调制抄本的超过 24h 结果的 CHL27 silencing 氧化 stress-responsiveand 铺平联系光合作用的原子基因(PhANGs ) 。CHLH 和 CHLM 的延长释放导致 PhANGs 和联系 tetrapyrrole 的基因的稍微提高的抄本层次。为 NGE 上的 tetrapyrrole 生合成的贡献的这些解决时间的研究 indicatea 建筑群情形由 1 O 2-induced 发信号和调整反馈的翼 synthesis.Key 词: | Hagen Schlicke Annabel Salinas Hartwig Vivien Firtzlaff Andreas S. Richter , Christine Glasser Klaus Maier Iris Finkemeier Bernhard Grimm | 2014 | Molecular Plant2014，7，7： | 3 |
| 13 | Interactive decal compositing with discrete exponential maps显示文摘 | Ryan Schmidt Cindy Grimm Brian Wyvill | 2006 | ACM Transactions on Graphics (TOG)2006，，3： | 2 |
| 14 | Endoscopic Retrograde Cholangiopancreatography with Single-Balloon Enteroscopy Is Feasible in Patients with a Prior Roux-en-Y Anastomosis显示文摘 | Evan S. Dellon Geoffrey P. Kohn Douglas R. Morgan Ian S. Grimm | 2009 | Digestive Diseases and Sciences2009，，8： | 2 |
| 15 | Brainstem Glioma: A Review显示文摘 | Sean A. Grimm Marc C. Chamberlain | 2013 | Current Neurology and Neuroscience Reports2013，，5： | 2 |
| 16 | Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10显示文摘 | Mingzhong Zheng Dora Bocangel Blair Doneske Abner Mhashilkar Rajagopal Ramesh Kelly K. Hunt Suhendan Ekmekcioglu R. Bryan Sutton Nancy Poindexter Elizabeth A. Grimm Sunil Chada | 2007 | Cancer Immunology Immunotherapy2007，，2： | 2 |
| 17 | Comparison of in vitro effectiveness of mechanical thrombectomy devices显示文摘 | Muller-Hulsbeck S Grimm J Leidt J | 2001 | J Vase Intertal Radiol2001，12，10： | 2 |
| 18 | Influence of thrombus age on the mechanical thrombectomy efficacy of the amplatz thrombectomy device in vitro显示文摘 | Grimm J Jahnke T Muhle C | 2003 | Cardiovasc Intervent Radiol2003，26，3： | 2 |
| 19 | Cardiac-resynchronization therapy in heart failure with narrow QRS complexes显示文摘 | Beshai JF Grimm RA Nagueh SF | | New England Journal of Medicine0，，： | 2 |
| 20 | Meta-Analysis of Retrograde Signaling in Arabidopsis thaliana Reveals a Core Module of Genes Embedded in Complex Cellular Signaling Networks显示文摘Plastid-to-nucleus 发信号为响应 environmentaland 的细胞的新陈代谢的协作和调整是必要的植物房间的发展暗示。许多运作后退表明小径被描述了被反应的氧种类,光合作用氧化还原作用不平衡, tetrapyrrole 中介,和 othermetabolic 特点要触发的那 arethought。这里,我们基于 transcriptome 和蛋白质相互作用数据报导元分析。比较 outputof 这些小径揭示在 operationalretrograde 发信号上侵犯的六不同来源刺激的公共和怪癖。我们的学习提供新奇卓见进这些小径的相互影响,支持当还未知的存在 ofan 基因的核心反应模块在测试的所有条件下面正在被调整。我们的分析进一步的 highlightsaffiliated 规章的 cis 元素并且分类 abscisic 酸并且作为涉及反应 cascadesfollowing 的第二等的部件的基于植物生长素的发信号一个 plastidial 信号。我们的学习提供结构的全球分析和不同小径 involvedin plastid-to-nucleus 在这建筑群上发信号和一个新看法的接口细胞的通讯 network.Key 词: | Christine GlaiBer Georg Haberer Iris Finkemeier Thomas Pfannschmidt Tatjana Kleine Dario Leister KarI-Josef Dietz Rainer Erich Haiusler Bernhard Grimm Klaus Franz Xaver Mayer | 2014 | Molecular Plant2014，7，7： | 2 |
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