|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 2 | Teracluster LSSC-II--Its designing principles and applications in large scale numerical simulations显示文摘The teracluster LSSC-II installed at the State Key Laboratory of Scientific and Engineering Computing, Chinese Academy of Sciences is one of the most powerful PC clusters in China. It has a peek performance of 2Tflops. With a Linpack performance of 1.04Tflops, it is ranked at the 43rd place in the 20th TOP500 List (November 2002), 51st place in the 21st TOP500 List (June 2003), and the 82nd place in the 22nd TOP500 List (November 2003) with a new Linpack performance of 1.3Tflops. In this paper, we present some design principles of this cluster, as well as its applications in some large-scale numerical simulations. | ZHANG Linbo, CHEN Shiyi, LI Xinliang, CAO Jianwen, ZHANG Wensheng & GONG XingaoState Key Laboratory of Scientific and Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Department of Mechanical Engineering, The Johns Hopkins University and Center for Computational Science and Engineering, Peking University, Beijing 100875, China Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China Parallel Computing Laboratory, Institute of Software, Chinese Academy of Sciences, Beijing 100080, China Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Surface Physics Laboratory (National Key Laboratory), Fudan University, Shanghai 200433 Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China | 2004 | Science China Mathematics2004，47，z1： | 8 |
| 3 | Synthesis and Self-Assembly of Two 1,3-Alternate Thiacalix[4]arenes Derivatives Bearing Amide Groups显示文摘Two 1,3-alternate thiacalix[4]arene derivatives bearing amide groups, 1,3-alternate p-tert-butylthiacalix[4]arene tetraamide (4), and 1,3-alternate p-H-thiacalix[4]arene tetraamide (6) were prepared, and their crystal structures were determined by single-crystal X-ray diffraction method. The steric hindrances posed by tert-butyl groups play an important part in the synthesis and the self-assembly of the two compounds. Compound 6 was synthesized from the corresponding ester, which was obtained by the reaction of acid chloride with ammonia. In the crystal structure, compound 4 presents a highly symmetric molecular structure, while for compound 6, because of absence of tert-butyl groups, it presents a more flexible molecular structure. | LI Yan GUO Rong WANG Wei GONG Linbo CHEN Yuanyin GONG Shuling | 2013 | Wuhan University Journal of Natural Sciences2013，18，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员