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| 1 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 2 | Factors regulating spatial distribution of soil water content in small semiarid catchments显示文摘 | Gomez P A Martinez M M Albaladejo J | 2000 | Journal of Hydrology2000，253，： | 1 |
| 3 | A Prospective Multicentre Study of the Role of Anaemia as a Risk Factor in Haemodialysis Patients: the MAR Study显示文摘 | Portoles J Lopez Gomez J M Aljama P | 2007 | Nephrot Dial Transplant2007，22，2： | 1 |
| 4 | Cardiac ab- normalities in systemic lupus erythematosus显示文摘 | Nihoyannopoulos P Gomez PM Joshi J | 1990 | Circulation1990，81，： | 1 |
| 5 | A chemical, morphological, and electrochemical (XPS, SEM/EDX, CV, and EIS) analysis of electrochemically modified electrode surfaces of natural chalcopyrite (CuFeS2) and pyrite (FeS2) in alkaline solutions显示文摘 | VELASQUEZ P LEINEN D PASCUAL J RAMOS- BARRADO J R GREZ P GOMEZ H SCHREBLER R DEL RiO R CORDOVA R | 2005 | Journal of Physical Chemistry B2005，109，1： | 1 |
| 6 | Pendimethalin and oxyfluorfen degradation under two irrigation conditions over four years application 显示文摘 | Alister C A Gomez P A Rojas S | 2009 | Journal of Environment Science Health B2009，44，： | 1 |
| 7 | Interferongamma production by neutrophils during bacterial pneumonia in mice显示文摘 | Yamada M Gomez J C Chugh P E | 2011 | Am J Respir Crit Care Med2011，183，10： | 1 |
| 8 | Study of the course of theincidence angle during growth 显示文摘 | Mangione P Gomez D Senegas J | 1997 | Eur Spine J1997，6，3： | 1 |
| 9 | Convective air drying of apples as affected by blanching and calcium impregnation 显示文摘 | GONZALEZ-FESLER M SALVATORI D GOMEZ P | 2008 | Journal of Food Engineering2008，87，： | 1 |
| 10 | Enrichment of CD4^+ CD25^high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids 显示文摘 | Suarez A Lopez P Gomez J | 2006 | Ann Rheum Dis2006，65，11： | 1 |
| 11 | Biogenic amine production by Oenococcus oeni isolates from malolactic fermentation of Tempranillo wine显示文摘 | IZQUIERDO-CANAS P M GOMEZ ALONSO S RUIZ PEREZ P | 2009 | Journal of Food Protection2009，72，4： | 1 |
| 12 | Iatrogenic vascular lesions after cardiac catheterization显示文摘 | Manuel-Rimbau E Lozano P Gomez A | | 0，，09： | 1 |
| 13 | IGF1R gene expression as a predictive marker of re- sponse to ionizing radiation for patients with locally ad- vanced HPV16-positive cervical cancer显示文摘 | Moreno-Acosta P Gamboa O Sanchez de Gomez M | 2012 | Anticancer Re- s2012，32，10： | 1 |
| 14 | Application of pulsed light to patulin reduction in Mcllvaine buffer and apple products显示文摘 | FUNES G J GOMEZ P L RESNIK S L | 2013 | Food Control2013，30，2： | 1 |
| 15 | Performance evaluation of existing approaches for hybrid ad hoc networks across mobility models显示文摘 | FRANCISCO R J RUIZ P M GOMEZ S A | 2006 | Journal of Net Works2006，1，2： | 1 |
| 16 | Systemic and local effects of angiotensin II blockade in experimental diabetic nephropathy显示文摘 | Vieitez P Gomez O Uceda ER | 2008 | Renin Angiotensin Aldosterone Syst2008，9，2： | 1 |
| 17 | Retrosteral goiters : safety of surgical treatment 显示文摘 | Parra - Membrives P Sanchez - Blanco JM Gomez - Rubio D | 2003 | Int Surg2003，88，2： | 1 |
| 18 | Functional signifi- cance of peripheral head-shaking nystagmus显示文摘 | Perez P Llorente JL Gomez JR | 2004 | Laryngo- scope2004，114，： | 1 |
| 19 | Overview and Analysis of Methodologiesfor Buliding Ontologies 显示文摘 | Fernandez L Gomez P | 2002 | Knowledge Engineering Review(S1469-8005)2002，17，2： | 1 |
| 20 | Molecular characterization of the safracin biosynthetic pathway from Pseudomonasfluorescens A2-2: designing new cytotoxic compounds 显示文摘 | Velasco A Acebo P Gomez A | 2005 | Mol Microbiol2005，56，1： | 1 |
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