|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 细胞移植治疗脊髓损伤(英文)显示文摘Spinal cord injury can lead to severe motor,sensory and autonomic dysfunction.Currently,there is no effective treatment for the injured spinalcord.The transplantation of Schwann cells,neural stem cells or progenitor cells,olfactory ensheathing cells,oligodendrocyte precursor cells and mesenchymal stem cells has been investigated as potential therapies for spinal cord injury.However,little is known about the mechanisms through which these individual cell types promote repair and functional improvements.The five most commonly proposed mechanisms include neuroprotection,immunomodulation,axon regeneration,neuronal relay formation and myelin regeneration.A better understanding of the mechanisms whereby these cells promote functional improvements,as well as an appreciation of the obstacles in implementing these therapies and effectively modeling spinal cord injury,will be important to make cell transplantation a viable clinical option and may lead to the development of more targeted therapies. | Assinck P Duncan GJ Hilton BJ Plemel JR Tetzlaff W | 2017 | 中华神经外科疾病研究杂志2017，16，3： | 54 |
| 2 | MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration显示文摘 | Arora S Ranade AR Tran NL Nasser S Sridhar S Korn RL Ross JT Dhruv H Foss KM Sibenaller Z Ryken T Gotway MB Kim S Weiss GJ | 2011 | 中国神经肿瘤杂志2011，9，1： | 30 |
| 3 | Ultrasonically activated scalpel versus monopolar electrocautery shovel in laparoscopic total mesorectal excision for rectal cancer显示文摘AIM: To investigate the feasibility and safety of monopolar electrocautery shovel (ES) in laparoscopic total mesorectal excision (TME) with anal sphincter preservation for rectal cancer in order to reduce the cost of the laparoscopic operation, and to compare ES with the ultrasonically activated scalpel (US). METHODS: Forty patients with rectal cancer, who underwent laparoscopic TME with anal sphincter preservation from June 2005 to June 2007, were randomly divided into ultrasonic scalpel group and monopolar ES group, prospectively. White blood cells (WBC) were measured before and after operation, operative time, blood loss, pelvic volume of drainage, time of anal exhaust, visual analogue scales (VAS) and surgery-related complications were recorded. RESULTS: All the operations were successful; no one was converted to open procedure. No significant differences were observed in terms of preoperative and postoperative d 1 and d 3 WBC counts (P = 0.493, P = 0.375, P = 0.559), operation time (P = 0.235), blood loss (P = 0.296), anal exhaust time (P = 0.431), pelvicdrainage volume and VAS in postoperative d 1 (P = 0.431, P = 0.426) and d 3 (P = 0.844, P = 0.617) between ES group and US group. The occurrence of surgery-related complications such as anastomotic leakage and wound infection was the same in the two groups. CONCLUSION: ES is a safe and feasible tool as same as US used in laparoscopic TME with anal sphincter preservation for rectal cancer on the basis of the skillful laparoscopic technique and the complete understanding of laparoscopic pelvic anatomy. Application of ES can not only reduce the operation costs but also benef it the popularization of laparoscopic operation for rectal cancer patients. | Bao-Jun Zhou, Wei-Qing Song, Qing-Hui Yan, Jian-Hui Cai, Feng-An Wang, Jin Liu, Guo-Jian Zhang, Guo-Qiang Duan, Zhan-Xue Zhang, Department of Gastrointestinal Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China Author contributions: Zhou BJ, Song WQ, Yan QH, Cai JH, Wang FA, Liu J, Zhang GJ, Duan GQ and Zhang ZX contributed equally to this work Zhou BJ, Song WQ, Yan QH, Cai JH and Wang FA designed the research Zhou BJ, Liu J and Zhang GJ performed the research Duan GQ and Zhang ZX analyzed the data and Zhou BJ, Song WQ and Yan QH wrote the paper. | 2008 | World Journal of Gastroenterology2008，14，25： | 25 |
| 4 | 影响颅内动脉瘤破裂风险的患者个体特征(英文)显示文摘BACKGROUND AND PURPOSE Knowledge about risk factors contributes to understanding the pathophysiological mechanisms that cause intracranial aneurysm rupture and helps to develop possible treatment strategies.We aimed to study lifestyle and personal characteristics as risk factors for the rupture of intracranial aneurysms.METHODS We performed a case-control study with 250 patients with an aneurysmal subarachnoid hemorrhage and 206 patients with an unruptured intracranial aneurysm.All patients with an aneurysmal subarachnoid hemorrhage and patients with a unruptured intracranial aneurysm were asked to fill in a structured questionnaire about their lifestyle and medical history.For patients with an unruptured intracranial aneurysm,we also collected data on the indication for imaging.With logistic regression analysis,we identified independent risk factors for aneurysmal rupture.RESULTS Reasons for imaging in patients with an unruptured intracranial aneurysm were atherosclerotic disease(23%),positive family history(18%),headache(8%),preventive screening(3%),and other(46%).Factors that increased risk for aneurysmal rupture were smoking(odds ratio,1.9;95% confidence interval,1.2-3.0) and migraine(2.4;1.1-5.1);hypercholesterolemia decreased this risk(0.4;0.2-1.0),whereas a history of hypertension did not independently influence the risk.CONCLUSIONS Smoking,migraine and,inversely,hypercholesterolemia are independent risk factors for aneurysmal rupture.Data from the questionnaire are insufficient to conclude whether hypercholesterolemia or its treatment with statins exerts a risk-reducing effect.The pathophysiological mechanisms through which smoking and migraine increase the risk of aneurysmal rupture should be investigated in further studies.Although a history of hypertension does not increase risk of rupture,a sudden rise in blood pressure might still trigger aneurysmal rupture. | Vlak MH Rinkel GJ Greebe P Algra A | 2013 | 中华神经外科疾病研究杂志2013，12，3： | 17 |
| 5 | 预处理对动脉瘤性蛛网膜下腔出血病人脑血管痉挛的影响显示文摘背景最新实验证据表明:预处理能引起机体对抗脑血管痉挛的内源性保护机制。目的探讨在动脉瘤性蛛网膜下腔出血(aSAH)病人体内是否也存在这种内源性保护机制。方法回顾性分析一组多中心aSAH病人的缺血性预处理刺激情况:包括病人已存在狭窄闭塞性脑血管疾病和(或)脑梗死; | Kim YW Zipfel GJ Ogilvy CS 郭玉慧 周静 | 2014 | 中国微侵袭神经外科杂志2014，19，4： | 11 |
| 6 | 半髋表面置换治疗股骨头缺血性坏死的近、中期疗效分析显示文摘目的探讨半髋表面置换术治疗股骨头缺血性坏死的近、中期疗效与股骨假体的柄干角和下沉的关系。方法41例(48髋)金属半髋表面置换患者手术时的平均年龄为36.7岁,随访至少3年。均诊为股骨头缺血性坏死,FicatⅢ期35髋、Ⅳ期13髋;其髋臼相对正常。在术后骨盆X线片上测量股骨假体的柄干角,观察其下沉情况。结果全部病例均获随访,平均5.2年(3~8年)。平均的UCLA髋关节功能评分明显改善(P=0.001),5年生存率为83%。按UCLA评分标准,FicatⅢ期35髋术后的满意率为88.6%;Ⅳ期13髋术后的满意率为69.2%(P<0.05)。8髋(FicatⅢ期、Ⅳ期各4髋)疗效差,归为失败组。计算机辅助的X线片分析显示6髋的股骨假体有明显下沉(其柄干角小于130°),2髋的髋臼有破坏(1髋柄干角为128°,1髋为136°)。疗效好的40髋(成功组)的平均柄干角为139°,而失败组的平均柄干角为127°(P<0.05)。失败组中,6髋假体头中心和假体柄尖的下沉分别为5.02mm和4.85mm,其柄干角均小于130°;而成功组假体头中心和假体柄尖的下沉仅为1.48mm和1.04mm(P<0.05)。柄干角小于130°者其发生不良后果的机会增加7.1倍。计算机辅助的X线片分析显示股骨假体超过2mm下沉的时间为19.5个月,临床出现症状的时间为35.6个月(P<0.01)。结论金属半髋表面置换术的近、中期疗效满意。较大的股骨假体的柄干角可以减少股骨头颈区域的压力,从而可以减少下沉,提高存活率。运用计算机辅助的X线片分析可以预测假体的失败。 | 肖增明 詹新立 李世德 Cui Q Wang GJ | 2005 | 中华骨科杂志2005，25，12： | 10 |
| 7 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 8 | 溶栓疗法治疗急性卒中的近期经验显示文摘使用溶栓剂重建血流治疗急性脑缺血尚处于研究阶段。许多前瞻性多中心试验指出了静脉或动脉输注使脑动脉再通的可行性。最近报告的以血管造影术为基础的,静脉输注重组组织纤溶酶原激活剂(rt-PA)疗效的研究表明,rt-PA(duteplase)的血管再通与剂量率无明显关系,早期治疗可使30天时血管再通和神经功能后果获得改善。出血性转变及其相关的神经症状加重的发生率并不高于其他研究中未治疗者或文献资料。现有证据证明维持软脑膜侧支循环可能与静脉内输注rt-PA(alteplase)后的良好后果相关。最近一些前瞻性研究的经验将为今后纤溶法治疗急性缺血性卒中的研究提供依据。 | GJ del Zoppo 黄兆章 | 1994 | 国外医学(脑血管疾病分册)1994，2，4： | 7 |
| 9 | 12-Deoxyphorbol Esters from Euphorbia Fischeriana显示文摘12-DeoxyphorbolEstersfromEuphorbiaFischerianaWenZiLIU;XiaoYunWU;GenJinYANG;QingGaoMA;TianXiZHOU;XiCanTANGandGuoWeiQIN(Departm... | Liu, WZ Wu, XY Yang, GJ Ma, QG Zhou, TX Tang, XC Qin, GW | 1996 | Chinese Chemical Letters1996，7，10： | 7 |
| 10 | 一种新的用于腮腺切除术的Ⅴ形切口的可行性:初步研究显示文摘本文报道一种新的腮腺切除V形切口的设计,该切口仅涉及耳前和耳后切口,没有发际线或上颈部切口。可用于接近几乎所有表面腮腺区域.包括上部和前部,瘢痕最小。为了评估该技术的可行性、安全性和美容效果,前瞻性地招募15例(2015年9月-2016年9月)患者,将部分腮腺切除术作为良性腮腺肿瘤的主要治疗方法。 | Ahn D Sohn JH Lee GJ 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，4： | 6 |
| 11 | Analysis of the PINK1 gene in a cohort of patients with sporadic earlyonset parkinsonism in Taiwan显示文摘 | Fung HC Chen CM Hardy J Singleton AB Lee-Chen GJ Wu YR | 2006 | 中国生物学文摘2006，20，8： | 6 |
| 12 | 介绍一种用颜色显示法测细胞的生长及增殖显示文摘 | 薛彬 Edeman A Thorbecke GJ | 1987 | 北京医科大学学报1987，19，20： | 6 |
| 13 | Management and outcome of hepatocellular adenoma with massive bleeding at presentation显示文摘AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma(HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage(grade Ⅱ or Ⅲ) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging(MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short-and long-term complications and patient and lesion follow-up. RESULTS All patients were female(n = 23). Treatment in the acute phase consisted of embolization(n = 9, 39.1%), conservative therapy(n = 13, 56.5%), andother intervention(n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively(0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe shortterm complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in nonsurgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary(elective) treatment(i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented(4.3%). None of the patients experienced long-term complication(mean follow-up time: 36 mo). CONCLUSION With a 4.3% risk of rebleeding, secondary(elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm. | Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan NM Ijzermans | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 14 | 阿尔茨海默病患者脑血流的动态调节显示文摘脑自动调节和压力反射敏感性是维持脑血流量的关键机制。该研究评估了这些调控机制在阿尔茨海默病导致的痴呆和轻度认知障碍患者中是否受到影响,因为这会增加降压治疗的风险。 | 刘青 叶鹏 de Heus RAA de Jong DLK Sanders ML van Spijker GJ Oudegeest-Sander MH Hopman MT Lawlor BA Olde Rikkert MGM Claassen JAHR | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 15 | 用概率模型评估电机绝缘剩余寿命显示文摘 | Ande.,GJ 赵旺初 | 1992 | 国外大电机1992，，5： | 4 |
| 16 | 激光共焦显微成像的最新进展及其在生命科学研究中的应用显示文摘激光扫描共聚焦显微镜近年来得到了迅速发展,是近代最先进的细胞生物医学分析仪器之一。通过它可以对观察样品进行无创断层扫描和成像,在生物学和医学研究诊断的各个方面都得到了广泛的应用。本文主要介绍了激光扫描共焦显微镜的基本原理和发展状况,并着重介绍了在共焦荧光显微镜中采用薄荧光层和切片成像特性图来表征成像状态的功能。这种方法一般用于表征共聚焦和多光子显微镜的成像特性,是比较显微镜切片成像条件、成像质量等相关性能的重要依据。 | BRAKENHOFF GJ | 2009 | 生命科学2009，21，2： | 3 |
| 17 | EFFECT OF ANNEALING TEMPERATURE ON TEXTURE OF COLD-ROLLED Ni47Ti44Nb9 SHEET显示文摘EFFECTOFANNEALINGTEMPERATUREONTEXTUREOFCOLD-ROLLEDNi47Ti44Nb9SHEETYang;GuanjunXie;LiyingHu;WenyingDeng;JuHao;Shiming(No?.. | YANG, GJ XIE, LY HU, WY DENG, J HAO, SM | 1995 | 中国有色金属学会会刊:英文版1995，5，1： | 3 |
| 18 | 超声辅助下切割针吸活检诊断头颈部淋巴瘤:是否可以取代淋巴结摘取活检?显示文摘Sonography-assisted cutting needle biopsy in the head and neck for the diagnosis of lymphoma: can it replace lymph node extirpation? Pfeiffer J, Kayser G, Ridder GJ. Laryngoscope, 2009, 119(4):689-695. | Pfeiffer J Kayser G Ridder GJ | 2009 | 中国口腔颌面外科杂志2009，7，4： | 3 |
| 19 | Intercostal nerve implants t ransduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function显示文摘 | Blits B Dijkhuizen PA Boer GJ | 2000 | Exp Neurol2000，164，1： | 2 |
| 20 | Increased expression of the nitric oxide synthase gene and protein in corpus cavernosum by repeated dosing of udenafil in a rat model of chemical diabetogenesis显示文摘可勃起的机能障碍(编辑) 是糖尿病 mellitus (DM ) 的主要复杂并发症。这研究在糖尿病的老鼠的阴茎海绵体(CC ) 调查在编辑和组成的氮的氧化物 synthase (cNOS ) 的 downregulation 之间的关系。它也检验 udenafil 的效果,一种 phosphodiesterase 类型 5 (PDE5 ) 禁止者,在编辑和 cNOS 表示层次上。在 16 星期有在糖尿病的老鼠的 udenafil 的每日的口头的处理以后, intracavernous 压力 / 平均数动脉的压力(ICP/MAP ) 比率被记录测量可勃起的功能,并且 cNOS 表示用反向的 transcriptase (RT ) 被测量 -PCR 和 immunoblots。尽管 ICP/MAP 比率和 endothelial NOS (eNOS ) 和在 CC 的 neuronal NOS (nNOS ) 的表达式层次显著地在糖尿病的老鼠被减少,长期的 udenafil 处理改进了可勃起的函数并且与糖尿病的控制相比增加了 cNOS 表示。这些调查结果建议在 DM 的编辑是仔细,与减少的 cNOS 有关,在 CC 和那 udenafil 的表示有能力由 modulating cNOS 补偿这个病理学的变化表示。Udenafil 也在 cGMP (周期的 guanosine monophosphate ) 有一个禁止的角色降级。 | GJ Ahn HK Chung CH Lee KK Kang BO Ahn | 2009 | Asian Journal of Andrology2009，11，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员