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| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | Characterization of Cr(VI)-resistant bacteria isolated from Chromium-contaminated soil by tannery activity显示文摘 | A Pace L Giovannetti 2003 | 2003 | Current Microbiology2003，46，： | 1 |
| 3 | Florence conference on phenotype microarray analysis of environment, agriculture, and human health 19-21 March 2008, Florence, Italy 显示文摘 | Viti C Bochner BB Giovannetti L | 2008 | Ann Microbiol2008，58，2： | 1 |
| 4 | Characterization ofeveryday functioning in mild cognitive impairment: A direct assess-ment approach显示文摘 | Giovannetti T BettcherB M Brennan L^ | 2008 | Dement Geriatr Cogn Disord2008，25，4： | 1 |
| 5 | Positioning and Clock Synchronization through Entanglement 显示文摘 | Giovannetti V Lloyd S Maecone L | 2001 | Phys Rev A2001，65，2： | 1 |
| 6 | Quantumenhanced positioning and clock synchronization显示文摘 | GIOVANNETTI V LLOYD S MACCONE L | 2001 | Na-ture2001，412，： | 1 |
| 7 | Patterns of below-ground plant interconnections established by means of arbuscular mycorrhizal networks显示文摘 | Giovannetti M Sbrana C Avio L | 2004 | New Phytologist2004，，164： | 1 |
| 8 | Influence of polymor-phisms on EGFR targeted therapy in non-small-cell lung canc-er显示文摘 | Giovannetti E Erdem L Olcay E | 2011 | Front Biosci2011，16，： | 1 |
| 9 | Cytotoxic activity of gemcitabine and conelation with expression profile dmg-ralated genes in human lymphoid cells 显示文摘 | Giovannetti E Mey V Izni L | 2007 | Pharmacol Res2007，55，4： | 1 |
| 10 | Changes in coagulation indexes and occurrence of venous thromboembolism in patients with Cushing's syndrome:results from a prospective study before and after surgery 显示文摘 | Manetti L Bogazzi F Giovannetti C | 2010 | Eur J Endocfinol2010，163，5： | 1 |
| 11 | Depletion of the residues of colistin and amoxicillin in turkeys following simultaneous subcutaneous administration显示文摘 | TOMASI L GIOVANNETTI L RONDOLOTTI A | 1996 | Vet Res Commun1996，20，2： | 1 |
| 12 | Characterization of Cr (VD resistant bacteria ioslatde from chromium-contaminated soil by tannery activity 显示文摘 | Viti C Pace A Giovannetti L | 2003 | Current Microbiology2003，46，1： | 1 |
| 13 | 查看详情显示文摘 | V Giovannetti S Lloyd L Maccone | | 0，，04： | 1 |
| 14 | Quantum metrology显示文摘 | GIOVANNETTI V LLOYD S MACCONE L | | 0，，01： | 1 |
| 15 | Quantum-enhanced measurements: beating the standard quantum limit 显示文摘 | Giovannetti V Lloyd S Maccone L | 2004 | Science2004，，： | 1 |
| 16 | Quantum private queries 显示文摘 | Giovannetti V Lloyd S Maccone L | 2008 | Physical Review Letter2008，100，23： | 1 |
| 17 | Quantum enhanced positioning and clock synchronization 显示文摘 | Giovannetti V Lloyd S Maccone L | 2001 | Nature2001，，412： | 1 |
| 18 | Quantum private queries显示文摘 | Giovannetti V Lloyd S Maccone L | | 0，，2305： | 1 |
| 19 | Quantum private queries: security analysis 显示文摘 | Giovannetti V Lloyd S Maccone L | 2010 | IEEE Transactions on Information The- ory2010，56，7： | 1 |
| 20 | Positioning andclock synchronization through entanglement 显示文摘 | Giovannetti V Lloyd S Maccone L | 2001 | Phys Rev A2001，5，02： | 1 |
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